The dog as model for chemotherapy of the Chagas’ disease.
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/1418 |
Resumo: | In the present study, we investigated the role of dogs as experimental models for acute and chronic phases of Chagas’ disease, before and after therapeutic treatments. Dogs were infected with Trypanosoma cruzi strains of different susceptibilities to benznidazole (Bz) and treated with the same therapeutic scheme as used for human chagasic. The treatment with Bz was able to prevent death and induced parasitological cure in 62.5% (acute phase) and 38.7% (chronic recent phase) of the tested animals. These results were similar to those reported in clinical trials for treated human patients (cured and uncured) in both phases of the disease. We also showed that parasitologic and serologic tests for monitoring the cure were similar to those obtained for human trials. In addition, Polymerase chain reaction showed the highest sensitivity when compared with hemoculture as an indicator of parasite clearance. In conclusion, the proposed experimental model should be relevant for chemotherapy studies for the control of Chagas’ disease. |
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Guedes, Paulo Marcos da MattaVeloso, Vanja MariaTafuri, Washington LuizGalvão, Lúcia Maria da CunhaCarneiro, Cláudia MartinsLana, Marta deChiari, EglerSoares, Killarney AtaideBahia, Maria Terezinha2012-09-25T13:17:33Z2012-09-25T13:17:33Z2002GUEDES, P. M. da M. et al. The dog as model for chemotherapy of the Chagas’ disease. Acta Tropica, v. 84, n. 1, p. 9-17, out. 2002. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X02001390>. Acesso em: 25 set. 2012.0001706Xhttp://www.repositorio.ufop.br/handle/123456789/1418In the present study, we investigated the role of dogs as experimental models for acute and chronic phases of Chagas’ disease, before and after therapeutic treatments. Dogs were infected with Trypanosoma cruzi strains of different susceptibilities to benznidazole (Bz) and treated with the same therapeutic scheme as used for human chagasic. The treatment with Bz was able to prevent death and induced parasitological cure in 62.5% (acute phase) and 38.7% (chronic recent phase) of the tested animals. These results were similar to those reported in clinical trials for treated human patients (cured and uncured) in both phases of the disease. We also showed that parasitologic and serologic tests for monitoring the cure were similar to those obtained for human trials. In addition, Polymerase chain reaction showed the highest sensitivity when compared with hemoculture as an indicator of parasite clearance. In conclusion, the proposed experimental model should be relevant for chemotherapy studies for the control of Chagas’ disease.Chagas' diseaseChemotherapyTrypanosoma cruziCanine experimental modelThe dog as model for chemotherapy of the Chagas’ disease.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleO periódico Acta Tropica concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3282591025053.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://www.repositorio.ufop.br/bitstream/123456789/1418/5/license.txt8a4605be74aa9ea9d79846c1fba20a33MD55ORIGINALARTIGO_DogModelChemotherapy.pdfARTIGO_DogModelChemotherapy.pdfapplication/pdf171052http://www.repositorio.ufop.br/bitstream/123456789/1418/1/ARTIGO_DogModelChemotherapy.pdf3b018c60cd935c707d7efea05692e203MD51123456789/14182019-03-08 11:54:49.496oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-03-08T16:54:49Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
The dog as model for chemotherapy of the Chagas’ disease. |
title |
The dog as model for chemotherapy of the Chagas’ disease. |
spellingShingle |
The dog as model for chemotherapy of the Chagas’ disease. Guedes, Paulo Marcos da Matta Chagas' disease Chemotherapy Trypanosoma cruzi Canine experimental model |
title_short |
The dog as model for chemotherapy of the Chagas’ disease. |
title_full |
The dog as model for chemotherapy of the Chagas’ disease. |
title_fullStr |
The dog as model for chemotherapy of the Chagas’ disease. |
title_full_unstemmed |
The dog as model for chemotherapy of the Chagas’ disease. |
title_sort |
The dog as model for chemotherapy of the Chagas’ disease. |
author |
Guedes, Paulo Marcos da Matta |
author_facet |
Guedes, Paulo Marcos da Matta Veloso, Vanja Maria Tafuri, Washington Luiz Galvão, Lúcia Maria da Cunha Carneiro, Cláudia Martins Lana, Marta de Chiari, Egler Soares, Killarney Ataide Bahia, Maria Terezinha |
author_role |
author |
author2 |
Veloso, Vanja Maria Tafuri, Washington Luiz Galvão, Lúcia Maria da Cunha Carneiro, Cláudia Martins Lana, Marta de Chiari, Egler Soares, Killarney Ataide Bahia, Maria Terezinha |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guedes, Paulo Marcos da Matta Veloso, Vanja Maria Tafuri, Washington Luiz Galvão, Lúcia Maria da Cunha Carneiro, Cláudia Martins Lana, Marta de Chiari, Egler Soares, Killarney Ataide Bahia, Maria Terezinha |
dc.subject.por.fl_str_mv |
Chagas' disease Chemotherapy Trypanosoma cruzi Canine experimental model |
topic |
Chagas' disease Chemotherapy Trypanosoma cruzi Canine experimental model |
description |
In the present study, we investigated the role of dogs as experimental models for acute and chronic phases of Chagas’ disease, before and after therapeutic treatments. Dogs were infected with Trypanosoma cruzi strains of different susceptibilities to benznidazole (Bz) and treated with the same therapeutic scheme as used for human chagasic. The treatment with Bz was able to prevent death and induced parasitological cure in 62.5% (acute phase) and 38.7% (chronic recent phase) of the tested animals. These results were similar to those reported in clinical trials for treated human patients (cured and uncured) in both phases of the disease. We also showed that parasitologic and serologic tests for monitoring the cure were similar to those obtained for human trials. In addition, Polymerase chain reaction showed the highest sensitivity when compared with hemoculture as an indicator of parasite clearance. In conclusion, the proposed experimental model should be relevant for chemotherapy studies for the control of Chagas’ disease. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002 |
dc.date.accessioned.fl_str_mv |
2012-09-25T13:17:33Z |
dc.date.available.fl_str_mv |
2012-09-25T13:17:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUEDES, P. M. da M. et al. The dog as model for chemotherapy of the Chagas’ disease. Acta Tropica, v. 84, n. 1, p. 9-17, out. 2002. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X02001390>. Acesso em: 25 set. 2012. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/1418 |
dc.identifier.issn.none.fl_str_mv |
0001706X |
identifier_str_mv |
GUEDES, P. M. da M. et al. The dog as model for chemotherapy of the Chagas’ disease. Acta Tropica, v. 84, n. 1, p. 9-17, out. 2002. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0001706X02001390>. Acesso em: 25 set. 2012. 0001706X |
url |
http://www.repositorio.ufop.br/handle/123456789/1418 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
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UFOP |
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Repositório Institucional da UFOP |
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Repositório Institucional da UFOP |
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