Immunological profile of resistance and susceptibility innaturally infected dogs by Leishmania infantum.

• Autor(a) principal: Leal, Gleisiane Gomes de Almeida
• Data de Publicação: 2014
• Outros Autores: Roatt, Bruno Mendes, Soares, Rodrigo Dian de Oliveira Aguiar, Carneiro, Cláudia Martins, Giunchetti, Rodolfo Cordeiro, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Francisco, Amanda Fortes, Cardoso, Jamille Mirelle de Oliveira, Mathias, Fernando Augusto Siqueira, Oliveira, Rodrigo Corrêa de, Carneiro, Mariângela, Vital, Wendel Coura, Reis, Alexandre Barbosa
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFOP
• Texto Completo: http://www.repositorio.ufop.br/handle/123456789/6076; https://doi.org/10.1016/j.vetpar.2014.08.022
• topic: Immunophenotyping; Cytokines; Canine visceral leishmaniasis

Visceral leishmaniasis has a great impact on public health, and dogs are considered the maindomestic reservoir of Leishmania infantum, the causal parasite. In this study, 159 animalsnaturally infected by L. infantum from an endemic area of Brazil were evaluated through ananalysis of cellular responses, using flow cytometry, and of the hematological parameters.The results confirmed that disease progression is associated with anemia and reductionsin eosinophils, monocytes and lymphocytes. The investigation of the immune response,based on the immunophenotypic profile of peripheral blood, showed declines in the abso-lute numbers of T lymphocytes CD5+and their subsets (CD4+and CD8+) and a drop of Blymphocytes in asymptomatic seropositive (AD-II) and symptomatic seropositive (SD) dogs.Neutrophils, when stimulated with soluble antigen of L. infantum, showed higher synthesisof interferon (IFN)- _+in AD-II and SD groups, with decreased production of interleukin