Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats.
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/11993 http://dx.doi.org/10.5935/abc.20190166 |
Resumo: | Background: Arterial hypertension is a precursor to the development of heart and renal failure, furthermore is associated with elevated oxidative markers. Environmental enrichment of rodents increases performance in memory tasks, also appears to exert an antioxidant effect in the hippocampus of normotensive rats. Objectives: Evaluate the effect of environmental enrichment on oxidative stress in the ventrolateral medulla, heart, and kidneys of renovascular hypertensive rats. Methods: Forty male Fischer rats (6 weeks old) were divided into four groups: normotensive standard condition (Sham‑St), normotensive enriched environment (Sham-EE), hypertensive standard condition (2K1C-St), and hypertensive enriched environment (2K1C-EE). Animals were kept in enriched or standard cages for four weeks after all animals were euthanized. The level of significance was at p < 0.05. Results: 2K1C-St group presented higher mean arterial pressure (mmHg) 147.0 (122.0; 187.0) compared to Sham-St 101.0 (94.0; 109.0) and Sham-EE 106.0 (90.8; 117.8). Ventrolateral medulla from 2K1C-EE had higher superoxide dismutase (SOD) (49.1 ± 7.9 U/mg ptn) and catalase activity (0.8 ± 0.4 U/mg ptn) compared to SOD (24.1 ± 9.8 U/mg ptn) and catalase activity (0.3 ± 0.1 U/mg ptn) in 2K1C-St. 2K1C-EE presented lower lipid oxidation (0.39 ± 0.06 nmol/mg ptn) than 2K1C-St (0.53 ± 0.22 nmol/mg ptn) in ventrolateral medulla. Furthermore, the kidneys of 2K1C-EE (11.9 ± 2.3 U/mg ptn) animals presented higher superoxide-dismutase activity than those of 2K1C-St animals (9.1 ± 2.3 U/mg ptn). Conclusion: Environmental enrichment induced an antioxidant effect in the ventrolateral medulla and kidneys that contributes to reducing oxidative damage among hypertensive rats. (Arq Bras Cardiol. 2019; 113(5):905-912). |
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Sousa, Luiz Eduardo deFavero, Iuri Ferrari DelBezerra, Frank SilvaSouza, Ana Beatriz Farias deAlzamora, Andréia Carvalho2020-03-13T11:14:48Z2020-03-13T11:14:48Z2019SOUZA, L. E. et al. Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. Arquivos Brasileiros de Cardiologia, v. 113, n. 5, p. 905-912, 2019. Disponível em: <http://www.scielo.br/scielo.php?pid=S0066-782X2019001100905&script=sci_arttext>. Acesso em: 10 fev. 2020.1678-4170http://www.repositorio.ufop.br/handle/123456789/11993http://dx.doi.org/10.5935/abc.20190166Background: Arterial hypertension is a precursor to the development of heart and renal failure, furthermore is associated with elevated oxidative markers. Environmental enrichment of rodents increases performance in memory tasks, also appears to exert an antioxidant effect in the hippocampus of normotensive rats. Objectives: Evaluate the effect of environmental enrichment on oxidative stress in the ventrolateral medulla, heart, and kidneys of renovascular hypertensive rats. Methods: Forty male Fischer rats (6 weeks old) were divided into four groups: normotensive standard condition (Sham‑St), normotensive enriched environment (Sham-EE), hypertensive standard condition (2K1C-St), and hypertensive enriched environment (2K1C-EE). Animals were kept in enriched or standard cages for four weeks after all animals were euthanized. The level of significance was at p < 0.05. Results: 2K1C-St group presented higher mean arterial pressure (mmHg) 147.0 (122.0; 187.0) compared to Sham-St 101.0 (94.0; 109.0) and Sham-EE 106.0 (90.8; 117.8). Ventrolateral medulla from 2K1C-EE had higher superoxide dismutase (SOD) (49.1 ± 7.9 U/mg ptn) and catalase activity (0.8 ± 0.4 U/mg ptn) compared to SOD (24.1 ± 9.8 U/mg ptn) and catalase activity (0.3 ± 0.1 U/mg ptn) in 2K1C-St. 2K1C-EE presented lower lipid oxidation (0.39 ± 0.06 nmol/mg ptn) than 2K1C-St (0.53 ± 0.22 nmol/mg ptn) in ventrolateral medulla. Furthermore, the kidneys of 2K1C-EE (11.9 ± 2.3 U/mg ptn) animals presented higher superoxide-dismutase activity than those of 2K1C-St animals (9.1 ± 2.3 U/mg ptn). Conclusion: Environmental enrichment induced an antioxidant effect in the ventrolateral medulla and kidneys that contributes to reducing oxidative damage among hypertensive rats. (Arq Bras Cardiol. 2019; 113(5):905-912).This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o próprio artigo.info:eu-repo/semantics/openAccessOxidative stressEnvironmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/11993/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_EnvironmentalEnrichmentPromotes.pdfARTIGO_EnvironmentalEnrichmentPromotes.pdfapplication/pdf955514http://www.repositorio.ufop.br/bitstream/123456789/11993/1/ARTIGO_EnvironmentalEnrichmentPromotes.pdf21356e46f6389638ad555b4327256216MD51123456789/119932020-03-13 07:14:48.309oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-03-13T11:14:48Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
title |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
spellingShingle |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. Sousa, Luiz Eduardo de Oxidative stress |
title_short |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
title_full |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
title_fullStr |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
title_full_unstemmed |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
title_sort |
Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. |
author |
Sousa, Luiz Eduardo de |
author_facet |
Sousa, Luiz Eduardo de Favero, Iuri Ferrari Del Bezerra, Frank Silva Souza, Ana Beatriz Farias de Alzamora, Andréia Carvalho |
author_role |
author |
author2 |
Favero, Iuri Ferrari Del Bezerra, Frank Silva Souza, Ana Beatriz Farias de Alzamora, Andréia Carvalho |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Luiz Eduardo de Favero, Iuri Ferrari Del Bezerra, Frank Silva Souza, Ana Beatriz Farias de Alzamora, Andréia Carvalho |
dc.subject.por.fl_str_mv |
Oxidative stress |
topic |
Oxidative stress |
description |
Background: Arterial hypertension is a precursor to the development of heart and renal failure, furthermore is associated with elevated oxidative markers. Environmental enrichment of rodents increases performance in memory tasks, also appears to exert an antioxidant effect in the hippocampus of normotensive rats. Objectives: Evaluate the effect of environmental enrichment on oxidative stress in the ventrolateral medulla, heart, and kidneys of renovascular hypertensive rats. Methods: Forty male Fischer rats (6 weeks old) were divided into four groups: normotensive standard condition (Sham‑St), normotensive enriched environment (Sham-EE), hypertensive standard condition (2K1C-St), and hypertensive enriched environment (2K1C-EE). Animals were kept in enriched or standard cages for four weeks after all animals were euthanized. The level of significance was at p < 0.05. Results: 2K1C-St group presented higher mean arterial pressure (mmHg) 147.0 (122.0; 187.0) compared to Sham-St 101.0 (94.0; 109.0) and Sham-EE 106.0 (90.8; 117.8). Ventrolateral medulla from 2K1C-EE had higher superoxide dismutase (SOD) (49.1 ± 7.9 U/mg ptn) and catalase activity (0.8 ± 0.4 U/mg ptn) compared to SOD (24.1 ± 9.8 U/mg ptn) and catalase activity (0.3 ± 0.1 U/mg ptn) in 2K1C-St. 2K1C-EE presented lower lipid oxidation (0.39 ± 0.06 nmol/mg ptn) than 2K1C-St (0.53 ± 0.22 nmol/mg ptn) in ventrolateral medulla. Furthermore, the kidneys of 2K1C-EE (11.9 ± 2.3 U/mg ptn) animals presented higher superoxide-dismutase activity than those of 2K1C-St animals (9.1 ± 2.3 U/mg ptn). Conclusion: Environmental enrichment induced an antioxidant effect in the ventrolateral medulla and kidneys that contributes to reducing oxidative damage among hypertensive rats. (Arq Bras Cardiol. 2019; 113(5):905-912). |
publishDate |
2019 |
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2019 |
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2020-03-13T11:14:48Z |
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2020-03-13T11:14:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, L. E. et al. Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. Arquivos Brasileiros de Cardiologia, v. 113, n. 5, p. 905-912, 2019. Disponível em: <http://www.scielo.br/scielo.php?pid=S0066-782X2019001100905&script=sci_arttext>. Acesso em: 10 fev. 2020. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/11993 |
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1678-4170 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.5935/abc.20190166 |
identifier_str_mv |
SOUZA, L. E. et al. Environmental enrichment promotes antioxidant effect in the ventrolateral medulla and kidney of renovascular hypertensive rats. Arquivos Brasileiros de Cardiologia, v. 113, n. 5, p. 905-912, 2019. Disponível em: <http://www.scielo.br/scielo.php?pid=S0066-782X2019001100905&script=sci_arttext>. Acesso em: 10 fev. 2020. 1678-4170 |
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http://www.repositorio.ufop.br/handle/123456789/11993 http://dx.doi.org/10.5935/abc.20190166 |
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eng |
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