Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/4644 https://doi.org/10.1016/j.ygeno.2011.05.007 |
Resumo: | Mature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRNAs that displayed no conservation. These S. mansoni miRNAs are located on seven autosomal chromosomes and a sex (W) chromosome. miRNA expansion through gene duplication was suggested for at least two miRNA families miR-71 and mir-2. miRNA target finding analysis identified 389 predicted mRNA targets for the identified miRNAs and suggests that the sma-mir-71 may be involved in female sexual maturation. Given the important roles of miRNAs in animals, the identification and characterization of miRNAs in S. mansoni will facilitate novel approaches towards prevention and treatment of Schistosomiasis. |
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Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.MicroRNASchistosoma mansoniParasiteBioinformaticsMature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRNAs that displayed no conservation. These S. mansoni miRNAs are located on seven autosomal chromosomes and a sex (W) chromosome. miRNA expansion through gene duplication was suggested for at least two miRNA families miR-71 and mir-2. miRNA target finding analysis identified 389 predicted mRNA targets for the identified miRNAs and suggests that the sma-mir-71 may be involved in female sexual maturation. Given the important roles of miRNAs in animals, the identification and characterization of miRNAs in S. mansoni will facilitate novel approaches towards prevention and treatment of Schistosomiasis.2015-03-16T18:51:43Z2015-03-16T18:51:43Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGOMES, M. de S. et al. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics, San Diego, v. 98, p. 96-111, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0888754311001315>. Acesso em: 08 nov. 2014.0888-7543http://www.repositorio.ufop.br/handle/123456789/4644https://doi.org/10.1016/j.ygeno.2011.05.007O periódico Genomics concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120176341.info:eu-repo/semantics/openAccessGomes, Matheus de SouzaMuniyappa, Mohan KumarCarvalho, Sávio GonçalvesCota, Renata Guerra de SáSpillane, Charlesengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-06-25T16:37:34Zoai:repositorio.ufop.br:123456789/4644Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-06-25T16:37:34Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.none.fl_str_mv |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
title |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
spellingShingle |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Gomes, Matheus de Souza MicroRNA Schistosoma mansoni Parasite Bioinformatics |
title_short |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
title_full |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
title_fullStr |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
title_full_unstemmed |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
title_sort |
Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. |
author |
Gomes, Matheus de Souza |
author_facet |
Gomes, Matheus de Souza Muniyappa, Mohan Kumar Carvalho, Sávio Gonçalves Cota, Renata Guerra de Sá Spillane, Charles |
author_role |
author |
author2 |
Muniyappa, Mohan Kumar Carvalho, Sávio Gonçalves Cota, Renata Guerra de Sá Spillane, Charles |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Gomes, Matheus de Souza Muniyappa, Mohan Kumar Carvalho, Sávio Gonçalves Cota, Renata Guerra de Sá Spillane, Charles |
dc.subject.por.fl_str_mv |
MicroRNA Schistosoma mansoni Parasite Bioinformatics |
topic |
MicroRNA Schistosoma mansoni Parasite Bioinformatics |
description |
Mature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRNAs that displayed no conservation. These S. mansoni miRNAs are located on seven autosomal chromosomes and a sex (W) chromosome. miRNA expansion through gene duplication was suggested for at least two miRNA families miR-71 and mir-2. miRNA target finding analysis identified 389 predicted mRNA targets for the identified miRNAs and suggests that the sma-mir-71 may be involved in female sexual maturation. Given the important roles of miRNAs in animals, the identification and characterization of miRNAs in S. mansoni will facilitate novel approaches towards prevention and treatment of Schistosomiasis. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2015-03-16T18:51:43Z 2015-03-16T18:51:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
GOMES, M. de S. et al. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics, San Diego, v. 98, p. 96-111, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0888754311001315>. Acesso em: 08 nov. 2014. 0888-7543 http://www.repositorio.ufop.br/handle/123456789/4644 https://doi.org/10.1016/j.ygeno.2011.05.007 |
identifier_str_mv |
GOMES, M. de S. et al. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics, San Diego, v. 98, p. 96-111, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0888754311001315>. Acesso em: 08 nov. 2014. 0888-7543 |
url |
http://www.repositorio.ufop.br/handle/123456789/4644 https://doi.org/10.1016/j.ygeno.2011.05.007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFOP instname:Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
instname_str |
Universidade Federal de Ouro Preto (UFOP) |
instacron_str |
UFOP |
institution |
UFOP |
reponame_str |
Repositório Institucional da UFOP |
collection |
Repositório Institucional da UFOP |
repository.name.fl_str_mv |
Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP) |
repository.mail.fl_str_mv |
repositorio@ufop.edu.br |
_version_ |
1813002868616069120 |