Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.

Detalhes bibliográficos
Autor(a) principal: Gomes, Matheus de Souza
Data de Publicação: 2011
Outros Autores: Muniyappa, Mohan Kumar, Carvalho, Sávio Gonçalves, Cota, Renata Guerra de Sá, Spillane, Charles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/4644
https://doi.org/10.1016/j.ygeno.2011.05.007
Resumo: Mature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRNAs that displayed no conservation. These S. mansoni miRNAs are located on seven autosomal chromosomes and a sex (W) chromosome. miRNA expansion through gene duplication was suggested for at least two miRNA families miR-71 and mir-2. miRNA target finding analysis identified 389 predicted mRNA targets for the identified miRNAs and suggests that the sma-mir-71 may be involved in female sexual maturation. Given the important roles of miRNAs in animals, the identification and characterization of miRNAs in S. mansoni will facilitate novel approaches towards prevention and treatment of Schistosomiasis.
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spelling Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.MicroRNASchistosoma mansoniParasiteBioinformaticsMature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRNAs that displayed no conservation. These S. mansoni miRNAs are located on seven autosomal chromosomes and a sex (W) chromosome. miRNA expansion through gene duplication was suggested for at least two miRNA families miR-71 and mir-2. miRNA target finding analysis identified 389 predicted mRNA targets for the identified miRNAs and suggests that the sma-mir-71 may be involved in female sexual maturation. Given the important roles of miRNAs in animals, the identification and characterization of miRNAs in S. mansoni will facilitate novel approaches towards prevention and treatment of Schistosomiasis.2015-03-16T18:51:43Z2015-03-16T18:51:43Z2011info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfGOMES, M. de S. et al. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics, San Diego, v. 98, p. 96-111, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0888754311001315>. Acesso em: 08 nov. 2014.0888-7543http://www.repositorio.ufop.br/handle/123456789/4644https://doi.org/10.1016/j.ygeno.2011.05.007O periódico Genomics concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120176341.info:eu-repo/semantics/openAccessGomes, Matheus de SouzaMuniyappa, Mohan KumarCarvalho, Sávio GonçalvesCota, Renata Guerra de SáSpillane, Charlesengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOP2019-06-25T16:37:34Zoai:repositorio.ufop.br:123456789/4644Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-06-25T16:37:34Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.none.fl_str_mv Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
title Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
spellingShingle Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
Gomes, Matheus de Souza
MicroRNA
Schistosoma mansoni
Parasite
Bioinformatics
title_short Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
title_full Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
title_fullStr Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
title_full_unstemmed Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
title_sort Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni.
author Gomes, Matheus de Souza
author_facet Gomes, Matheus de Souza
Muniyappa, Mohan Kumar
Carvalho, Sávio Gonçalves
Cota, Renata Guerra de Sá
Spillane, Charles
author_role author
author2 Muniyappa, Mohan Kumar
Carvalho, Sávio Gonçalves
Cota, Renata Guerra de Sá
Spillane, Charles
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Matheus de Souza
Muniyappa, Mohan Kumar
Carvalho, Sávio Gonçalves
Cota, Renata Guerra de Sá
Spillane, Charles
dc.subject.por.fl_str_mv MicroRNA
Schistosoma mansoni
Parasite
Bioinformatics
topic MicroRNA
Schistosoma mansoni
Parasite
Bioinformatics
description Mature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRNAs that displayed no conservation. These S. mansoni miRNAs are located on seven autosomal chromosomes and a sex (W) chromosome. miRNA expansion through gene duplication was suggested for at least two miRNA families miR-71 and mir-2. miRNA target finding analysis identified 389 predicted mRNA targets for the identified miRNAs and suggests that the sma-mir-71 may be involved in female sexual maturation. Given the important roles of miRNAs in animals, the identification and characterization of miRNAs in S. mansoni will facilitate novel approaches towards prevention and treatment of Schistosomiasis.
publishDate 2011
dc.date.none.fl_str_mv 2011
2015-03-16T18:51:43Z
2015-03-16T18:51:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv GOMES, M. de S. et al. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics, San Diego, v. 98, p. 96-111, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0888754311001315>. Acesso em: 08 nov. 2014.
0888-7543
http://www.repositorio.ufop.br/handle/123456789/4644
https://doi.org/10.1016/j.ygeno.2011.05.007
identifier_str_mv GOMES, M. de S. et al. Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni. Genomics, San Diego, v. 98, p. 96-111, 2011. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0888754311001315>. Acesso em: 08 nov. 2014.
0888-7543
url http://www.repositorio.ufop.br/handle/123456789/4644
https://doi.org/10.1016/j.ygeno.2011.05.007
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFOP
instname:Universidade Federal de Ouro Preto (UFOP)
instacron:UFOP
instname_str Universidade Federal de Ouro Preto (UFOP)
instacron_str UFOP
institution UFOP
reponame_str Repositório Institucional da UFOP
collection Repositório Institucional da UFOP
repository.name.fl_str_mv Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)
repository.mail.fl_str_mv repositorio@ufop.edu.br
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