Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.

Detalhes bibliográficos
Autor(a) principal: Nascimento, Andréa Mendes do
Data de Publicação: 2012
Outros Autores: Conti, Raphael, Turatti, Izabel Cristina Casanova, Cavalcanti, Bruno Coêlho, Lotufo, Leticia Veras Costa, Pessoa, Cláudia, Moraes Filho, Manoel Odorico de, Manfrim, Viviane, Toledo, Juliano Simões de, Cruz, Angela Kaysel, Pupo, Mônica Tallarico
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFOP
Texto Completo: http://www.repositorio.ufop.br/handle/123456789/4862
http://dx.doi.org/10.1590/S0102-695X2012005000106
Resumo: Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their 1H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.
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spelling Nascimento, Andréa Mendes doConti, RaphaelTuratti, Izabel Cristina CasanovaCavalcanti, Bruno CoêlhoLotufo, Leticia Veras CostaPessoa, CláudiaMoraes Filho, Manoel Odorico deManfrim, VivianeToledo, Juliano Simões deCruz, Angela KayselPupo, Mônica Tallarico2015-04-01T17:14:55Z2015-04-01T17:14:55Z2012NASCIMENTO, A. M. do et al. Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum. Revista Brasileira de Farmacognosia, v. 22, p. 1276-1281, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=s0102-695x2012000600010&script=sci_arttext>. Acesso em: 02 fev. 2015.1981-528Xhttp://www.repositorio.ufop.br/handle/123456789/4862http://dx.doi.org/10.1590/S0102-695X2012005000106Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their 1H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.BeauvericinCitotoxic activityEndophytic fungusFusarium oxysporumLeishmania braziliensisBioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleA Revista Brasileira de Farmacognosia permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida Mediante prenchimento de formulário em 16 set. 2013.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-82636http://www.repositorio.ufop.br/bitstream/123456789/4862/2/license.txtc2ffdd99e58acf69202dff00d361f23aMD52ORIGINALARTIGO_BioactiveExtractChemical.pdfARTIGO_BioactiveExtractChemical.pdfapplication/pdf747154http://www.repositorio.ufop.br/bitstream/123456789/4862/1/ARTIGO_BioactiveExtractChemical.pdf5885ecc3e4bb64a2ff2e5fd49b42ec3cMD51123456789/48622019-07-02 13:27:54.668oai:localhost: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Repositório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332019-07-02T17:27:54Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false
dc.title.pt_BR.fl_str_mv Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
title Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
spellingShingle Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
Nascimento, Andréa Mendes do
Beauvericin
Citotoxic activity
Endophytic fungus
Fusarium oxysporum
Leishmania braziliensis
title_short Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
title_full Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
title_fullStr Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
title_full_unstemmed Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
title_sort Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum.
author Nascimento, Andréa Mendes do
author_facet Nascimento, Andréa Mendes do
Conti, Raphael
Turatti, Izabel Cristina Casanova
Cavalcanti, Bruno Coêlho
Lotufo, Leticia Veras Costa
Pessoa, Cláudia
Moraes Filho, Manoel Odorico de
Manfrim, Viviane
Toledo, Juliano Simões de
Cruz, Angela Kaysel
Pupo, Mônica Tallarico
author_role author
author2 Conti, Raphael
Turatti, Izabel Cristina Casanova
Cavalcanti, Bruno Coêlho
Lotufo, Leticia Veras Costa
Pessoa, Cláudia
Moraes Filho, Manoel Odorico de
Manfrim, Viviane
Toledo, Juliano Simões de
Cruz, Angela Kaysel
Pupo, Mônica Tallarico
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nascimento, Andréa Mendes do
Conti, Raphael
Turatti, Izabel Cristina Casanova
Cavalcanti, Bruno Coêlho
Lotufo, Leticia Veras Costa
Pessoa, Cláudia
Moraes Filho, Manoel Odorico de
Manfrim, Viviane
Toledo, Juliano Simões de
Cruz, Angela Kaysel
Pupo, Mônica Tallarico
dc.subject.por.fl_str_mv Beauvericin
Citotoxic activity
Endophytic fungus
Fusarium oxysporum
Leishmania braziliensis
topic Beauvericin
Citotoxic activity
Endophytic fungus
Fusarium oxysporum
Leishmania braziliensis
description Ethyl acetate extracts of cultures grown in liquid Czapek and on solid rice media of the fungal endophyte Fusarium oxysporum SS46 isolated from the medicinal plant Smallanthus sonchifolius (Poepp.) H. Rob., Asteraceae, exhibited considerable cytotoxic activity when tested in vitro against human cancer cells. Chromatographic separation yielded anhydrofusarubin (1) and beauvericin (2) that were identified based on their 1H and 13C NMR data. Compounds 1 and 2 showed the strongest cytotoxic activity against different cancer cell lines. Compound 2 also showed promising activity against Leishmania braziliensis. Hexanic extract of F. oxysporum SS50 grown on solid rice media also afforded a mixture of compounds that displayed cytotoxic activity against different cancer cell lines. Chemical analysis of the mixture of compounds, investigated by gas chromatography-mass spectrometry (GC-MS), showed that there was a predominance of methyl esters of fatty acids and alkanes.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2015-04-01T17:14:55Z
dc.date.available.fl_str_mv 2015-04-01T17:14:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv NASCIMENTO, A. M. do et al. Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum. Revista Brasileira de Farmacognosia, v. 22, p. 1276-1281, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=s0102-695x2012000600010&script=sci_arttext>. Acesso em: 02 fev. 2015.
dc.identifier.uri.fl_str_mv http://www.repositorio.ufop.br/handle/123456789/4862
dc.identifier.issn.none.fl_str_mv 1981-528X
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0102-695X2012005000106
identifier_str_mv NASCIMENTO, A. M. do et al. Bioactive extracts and chemical constituents of two endophytic strains of Fusarium oxysporum. Revista Brasileira de Farmacognosia, v. 22, p. 1276-1281, 2012. Disponível em: <http://www.scielo.br/scielo.php?pid=s0102-695x2012000600010&script=sci_arttext>. Acesso em: 02 fev. 2015.
1981-528X
url http://www.repositorio.ufop.br/handle/123456789/4862
http://dx.doi.org/10.1590/S0102-695X2012005000106
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language eng
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