Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira em Promoção da Saúde |
Texto Completo: | https://ojs.unifor.br/RBPS/article/view/976 |
Resumo: | In order to allow early diagnosis and more efficient treatments, many studies have been trying to define genetic markers of rheumatic diseases. Amongst them, antigens and alleles of the HLA (Human Leukocyte Antigens) system are distinguished. Located in the short arm of chromosome 6, the HLA system exerts genetic influence on the susceptibility and severity of these diseases. The discovery of new molecular methods to typify HLA alleles and the recent nomenclature updates have been contributing to a better understanding of this system. Unfortunately, this information has not been adequately published in the clinical literature. The present work aimed at presenting the function, nomenclature and methods of detection of the HLA polymorphism; and to review its associations with rheumatic fever, systemic erythematosus lupus, rheumatoid arthritis, juvenile idiopathic arthritis and spondyloarthropathies. Articles that were published between 1980 and 2005 were searched in the MEDLINE and LILACS data basis. This review demonstrated that although the HLA association is well established for some rheumatic diseases (e.g., HLA-B27 and spondyloarthropathies, HLA DR-3 and HLA-DR4 with rheumatoid arthritis, HLA-DR4 and lupus) others vary in different ethnic-racial group and illnesses, due to its polymorphism. It is necessary to study populations from different ethnic backgrounds to identify new associations or to strengthen associations with the ones already identified. This knowledge will contribute to future prophylactic or therapeutic interventions in patients with rheumatic disorders or at risk to develop them. |
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Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155Complexo principal de histocompatibilidade: sua participação na patogênese das doenças reumáticas auto-imunes - doi:10.5020/18061230.2006.p155Antígenos HLAComplexo principal de histocompatibilidadeDoenças reumáticas.In order to allow early diagnosis and more efficient treatments, many studies have been trying to define genetic markers of rheumatic diseases. Amongst them, antigens and alleles of the HLA (Human Leukocyte Antigens) system are distinguished. Located in the short arm of chromosome 6, the HLA system exerts genetic influence on the susceptibility and severity of these diseases. The discovery of new molecular methods to typify HLA alleles and the recent nomenclature updates have been contributing to a better understanding of this system. Unfortunately, this information has not been adequately published in the clinical literature. The present work aimed at presenting the function, nomenclature and methods of detection of the HLA polymorphism; and to review its associations with rheumatic fever, systemic erythematosus lupus, rheumatoid arthritis, juvenile idiopathic arthritis and spondyloarthropathies. Articles that were published between 1980 and 2005 were searched in the MEDLINE and LILACS data basis. This review demonstrated that although the HLA association is well established for some rheumatic diseases (e.g., HLA-B27 and spondyloarthropathies, HLA DR-3 and HLA-DR4 with rheumatoid arthritis, HLA-DR4 and lupus) others vary in different ethnic-racial group and illnesses, due to its polymorphism. It is necessary to study populations from different ethnic backgrounds to identify new associations or to strengthen associations with the ones already identified. This knowledge will contribute to future prophylactic or therapeutic interventions in patients with rheumatic disorders or at risk to develop them.A fim de possibilitar diagnósticos precoces e tratamentos mais eficazes, muitos estudos vêm tentando definir marcadores genéticos de doenças reumáticas. Dentre eles, destacam-se antígenos e alelos do complexo principal de histocompatibilidade, sistema HLA (Human Leukocyte Antigens). Localizado no braço curto do cromossomo 6, o sistema HLA exerce influência genética sobre asusceptibilidade, manifestação clínica e severidade dessas doenças. Novos métodos moleculares para tipificação dos alelos HLA e as constantes atualizações de sua nomenclatura têm contribuído para o melhor entendimento desse sistema. Infelizmente, essas informações não têm sido adequadamente veiculadas na literatura clínica. O presente trabalho tem por objetivo apresentar a função, a nomenclatura e os métodos de detecção do polimorfismo HLA e relatar suas associações com febre reumática, lúpus eritematoso sistêmico, artrite reumatóide, artrite idiopática juvenil e espondiloartropatias. Foram pesquisados, através das bases de dados MEDLINE e LILACS, artigos publicados de 1980 a 2005. Essa revisão mostrou que, embora o HLA esteja associado com algumas doenças reumáticas (e.g., HLA-B27 e espondiloartropatias, HLA-DR3/DR4 e artrite reumatóide, HLA-DR2/DR3 e lupus eritematoso), outras associações variam entre diferentes etnias e doenças, em virtude de seu polimorfismo. Portanto, é necessário pesquisar populações de várias etnias para identificar novas associações ou reforçar aquelas já existentes. Esse conhecimento contribuirá para futuras intervenções profiláticas ou terapêuticas nos pacientes com doenças reumáticas e naqueles com risco elevado de desenvolvê-las.Universidade de Fortaleza2012-01-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed Article""Avaliado pelos pares""Avaliado pelos pares"application/pdfhttps://ojs.unifor.br/RBPS/article/view/97610.5020/976Brazilian Journal in Health Promotion; Vol. 19 No. 3 (2006); 155-163Revista Brasileña en Promoción de la Salud; Vol. 19 Núm. 3 (2006); 155-163Revista Brasileira em Promoção da Saúde; v. 19 n. 3 (2006); 155-1631806-1230reponame:Revista Brasileira em Promoção da Saúdeinstname:Universidade de Fortaleza (Unifor)instacron:UFORporhttps://ojs.unifor.br/RBPS/article/view/976/2138Alves, CrésioMeyer, IsadoraToralles, Maria Betânia PereiraSantiago, Mittermayer Barretoinfo:eu-repo/semantics/openAccess2012-01-10T12:18:14Zoai:ojs.ojs.unifor.br:article/976Revistahttps://periodicos.unifor.br/RBPS/oai1806-12301806-1222opendoar:2012-01-10T12:18:14Revista Brasileira em Promoção da Saúde - Universidade de Fortaleza (Unifor)false |
dc.title.none.fl_str_mv |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 Complexo principal de histocompatibilidade: sua participação na patogênese das doenças reumáticas auto-imunes - doi:10.5020/18061230.2006.p155 |
title |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 |
spellingShingle |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 Alves, Crésio Antígenos HLA Complexo principal de histocompatibilidade Doenças reumáticas. |
title_short |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 |
title_full |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 |
title_fullStr |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 |
title_full_unstemmed |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 |
title_sort |
Major histocompatibility complex: its role in the pathogenesis of autoimmune rheumatic diseases - doi:10.5020/18061230.2006.p155 |
author |
Alves, Crésio |
author_facet |
Alves, Crésio Meyer, Isadora Toralles, Maria Betânia Pereira Santiago, Mittermayer Barreto |
author_role |
author |
author2 |
Meyer, Isadora Toralles, Maria Betânia Pereira Santiago, Mittermayer Barreto |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Alves, Crésio Meyer, Isadora Toralles, Maria Betânia Pereira Santiago, Mittermayer Barreto |
dc.subject.por.fl_str_mv |
Antígenos HLA Complexo principal de histocompatibilidade Doenças reumáticas. |
topic |
Antígenos HLA Complexo principal de histocompatibilidade Doenças reumáticas. |
description |
In order to allow early diagnosis and more efficient treatments, many studies have been trying to define genetic markers of rheumatic diseases. Amongst them, antigens and alleles of the HLA (Human Leukocyte Antigens) system are distinguished. Located in the short arm of chromosome 6, the HLA system exerts genetic influence on the susceptibility and severity of these diseases. The discovery of new molecular methods to typify HLA alleles and the recent nomenclature updates have been contributing to a better understanding of this system. Unfortunately, this information has not been adequately published in the clinical literature. The present work aimed at presenting the function, nomenclature and methods of detection of the HLA polymorphism; and to review its associations with rheumatic fever, systemic erythematosus lupus, rheumatoid arthritis, juvenile idiopathic arthritis and spondyloarthropathies. Articles that were published between 1980 and 2005 were searched in the MEDLINE and LILACS data basis. This review demonstrated that although the HLA association is well established for some rheumatic diseases (e.g., HLA-B27 and spondyloarthropathies, HLA DR-3 and HLA-DR4 with rheumatoid arthritis, HLA-DR4 and lupus) others vary in different ethnic-racial group and illnesses, due to its polymorphism. It is necessary to study populations from different ethnic backgrounds to identify new associations or to strengthen associations with the ones already identified. This knowledge will contribute to future prophylactic or therapeutic interventions in patients with rheumatic disorders or at risk to develop them. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion "Peer-reviewed Article" "Avaliado pelos pares" "Avaliado pelos pares" |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.unifor.br/RBPS/article/view/976 10.5020/976 |
url |
https://ojs.unifor.br/RBPS/article/view/976 |
identifier_str_mv |
10.5020/976 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.unifor.br/RBPS/article/view/976/2138 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de Fortaleza |
publisher.none.fl_str_mv |
Universidade de Fortaleza |
dc.source.none.fl_str_mv |
Brazilian Journal in Health Promotion; Vol. 19 No. 3 (2006); 155-163 Revista Brasileña en Promoción de la Salud; Vol. 19 Núm. 3 (2006); 155-163 Revista Brasileira em Promoção da Saúde; v. 19 n. 3 (2006); 155-163 1806-1230 reponame:Revista Brasileira em Promoção da Saúde instname:Universidade de Fortaleza (Unifor) instacron:UFOR |
instname_str |
Universidade de Fortaleza (Unifor) |
instacron_str |
UFOR |
institution |
UFOR |
reponame_str |
Revista Brasileira em Promoção da Saúde |
collection |
Revista Brasileira em Promoção da Saúde |
repository.name.fl_str_mv |
Revista Brasileira em Promoção da Saúde - Universidade de Fortaleza (Unifor) |
repository.mail.fl_str_mv |
|
_version_ |
1798313056371998720 |