Copaiba oil effect on experimental jaw defect in Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/6488 http://dx.doi.org/10.1590/S0102-86502015002000006 |
Resumo: | PURPOSE: To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS: A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects. RESULTS: The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60). CONCLUSIONS: The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated whit meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model. |
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2015-03-25T13:36:19Z2015-03-25T13:36:19Z2015-02SILVA, Priscilla Flores et al. Copaiba oil effect on experimental jaw defect in Wistar rats. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 2, p. 120-126, Feb. 2015. DOI: http://dx.doi.org/10.1590/S0102-86502015002000006. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6488. Acesso em:.1678-2674http://repositorio.ufpa.br/jspui/handle/2011/6488http://dx.doi.org/10.1590/S0102-86502015002000006PURPOSE: To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS: A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects. RESULTS: The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60). CONCLUSIONS: The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated whit meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model.SILVA, P. F.; PONTES, F. S. C.; MENDES, L. C.; OLIVEIRA, L. C. M. Universidade Federal do ParáengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaSOBRADPECActa Cirúrgica Brasileirahttp://ref.scielo.org/t7654creponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAPlantas medicinaisÓleo de copaíbaRegeneração ósseaAnti-inflamatóriosRato como animal de laboratórioPlantsMedicinalBone regenerationAnti-Inflammatory agentsCopaiba oil effect on experimental jaw defect in Wistar ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article302120126http://lattes.cnpq.br/8788028321547506http://lattes.cnpq.br/1180984403274256http://lattes.cnpq.br/3853022506850236http://lattes.cnpq.br/7763463771018956http://lattes.cnpq.br/2687223302542581http://lattes.cnpq.br/6935124190761059SILVA, Priscilla FloresBRITO, Marcus Vinicius HenriquesPONTES, Flávia Sirotheau CorrêaRAMOS, Suzana RodriguesMENDES, Laís CordeiroOLIVEIRA, Louize Caroline Marquesinfo:eu-repo/semantics/openAccessORIGINALArticle_CopaibaOilEffect.pdfArticle_CopaibaOilEffect.pdfapplication/pdf669875http://repositorio.ufpa.br/oai/bitstream/2011/6488/1/Article_CopaibaOilEffect.pdfce7267c64d5acab50d2f1440ed3db7d1MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/6488/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-822376http://repositorio.ufpa.br/oai/bitstream/2011/6488/3/license_textd4b12fbc55dda86e4a445686ff8a56f3MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-822190http://repositorio.ufpa.br/oai/bitstream/2011/6488/4/license_rdf19e8a2b57ef43c09f4d7071d2153c97dMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81703http://repositorio.ufpa.br/oai/bitstream/2011/6488/5/license.txta12ee01655d4f43dacf016d5e6168febMD55TEXTArtigo_CopaibaOilEffect.pdf.txtArtigo_CopaibaOilEffect.pdf.txtExtracted texttext/plain22711http://repositorio.ufpa.br/oai/bitstream/2011/6488/6/Artigo_CopaibaOilEffect.pdf.txt560eeb865378f16845498e7c073cc2ebMD56Article_CopaibaOilEffect.pdf.txtArticle_CopaibaOilEffect.pdf.txtExtracted texttext/plain22711http://repositorio.ufpa.br/oai/bitstream/2011/6488/7/Article_CopaibaOilEffect.pdf.txt560eeb865378f16845498e7c073cc2ebMD572011/64882020-01-27 13:27:29.689oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232020-01-27T16:27:29Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.en.fl_str_mv |
Copaiba oil effect on experimental jaw defect in Wistar rats |
title |
Copaiba oil effect on experimental jaw defect in Wistar rats |
spellingShingle |
Copaiba oil effect on experimental jaw defect in Wistar rats SILVA, Priscilla Flores Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents |
title_short |
Copaiba oil effect on experimental jaw defect in Wistar rats |
title_full |
Copaiba oil effect on experimental jaw defect in Wistar rats |
title_fullStr |
Copaiba oil effect on experimental jaw defect in Wistar rats |
title_full_unstemmed |
Copaiba oil effect on experimental jaw defect in Wistar rats |
title_sort |
Copaiba oil effect on experimental jaw defect in Wistar rats |
author |
SILVA, Priscilla Flores |
author_facet |
SILVA, Priscilla Flores BRITO, Marcus Vinicius Henriques PONTES, Flávia Sirotheau Corrêa RAMOS, Suzana Rodrigues MENDES, Laís Cordeiro OLIVEIRA, Louize Caroline Marques |
author_role |
author |
author2 |
BRITO, Marcus Vinicius Henriques PONTES, Flávia Sirotheau Corrêa RAMOS, Suzana Rodrigues MENDES, Laís Cordeiro OLIVEIRA, Louize Caroline Marques |
author2_role |
author author author author author |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8788028321547506 http://lattes.cnpq.br/1180984403274256 http://lattes.cnpq.br/3853022506850236 http://lattes.cnpq.br/7763463771018956 http://lattes.cnpq.br/2687223302542581 http://lattes.cnpq.br/6935124190761059 |
dc.contributor.author.fl_str_mv |
SILVA, Priscilla Flores BRITO, Marcus Vinicius Henriques PONTES, Flávia Sirotheau Corrêa RAMOS, Suzana Rodrigues MENDES, Laís Cordeiro OLIVEIRA, Louize Caroline Marques |
dc.subject.por.fl_str_mv |
Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório |
topic |
Plantas medicinais Óleo de copaíba Regeneração óssea Anti-inflamatórios Rato como animal de laboratório Plants Medicinal Bone regeneration Anti-Inflammatory agents |
dc.subject.eng.fl_str_mv |
Plants Medicinal Bone regeneration Anti-Inflammatory agents |
description |
PURPOSE: To evaluate the effects of copaiba oil on jaw defects repair in Wistar rats treated with bioglass or adipose tissue. METHODS: A jaw defect was randomly created in forty-two rats and filled with bioglass or adipose tissue. The two groups (Gbio and Gcell) were subdivided in three subgroups with seven animals each according to gavage administration: control (distillated water), oil (copaiba oil) and melox (meloxicam). Euthanasia was performed after forty post-operative days. The bone formation was analyzed regarding the histological aspects. RESULTS: The osteoclasts activity was observed only in four subgroups (p=0.78). Regarding the osteoblasts presence, it was very similar between the subgroups, the difference was due to Gcell-melox (p=0.009) that presented less osteoblastic activity. The inflammatory cells were more evident in Gcell-melox subgroup, however, there was no difference in comparison with the other subgroups (p=0.52). Bone formation was observed in all subgroups, just two animals showed no bone formation even after 40 days. More than 50% of bone matrix mineralization was observed in 56% (23 animals) of the analyzed areas. The bone matrix mineralization was not different between subgroups (p=0.60). CONCLUSIONS: The subgroups that received copaiba oil showed bone repair, although not statistically significant in comparison to subgroups treated whit meloxicam or controls. Copaiba oil administered by gavage had no effect on bone repair in this experimental model. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-03-25T13:36:19Z |
dc.date.available.fl_str_mv |
2015-03-25T13:36:19Z |
dc.date.issued.fl_str_mv |
2015-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SILVA, Priscilla Flores et al. Copaiba oil effect on experimental jaw defect in Wistar rats. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 2, p. 120-126, Feb. 2015. DOI: http://dx.doi.org/10.1590/S0102-86502015002000006. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6488. Acesso em:. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/6488 |
dc.identifier.issn.none.fl_str_mv |
1678-2674 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502015002000006 |
identifier_str_mv |
SILVA, Priscilla Flores et al. Copaiba oil effect on experimental jaw defect in Wistar rats. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 2, p. 120-126, Feb. 2015. DOI: http://dx.doi.org/10.1590/S0102-86502015002000006. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6488. Acesso em:. 1678-2674 |
url |
http://repositorio.ufpa.br/jspui/handle/2011/6488 http://dx.doi.org/10.1590/S0102-86502015002000006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Acta Cirúrgica Brasileira |
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openAccess |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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SOBRADPEC |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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