Cerebral hemodynamic and metabolic changes in fulminant hepatic failure
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFPA |
| DOI: | 10.1590/0004-282x20170076 |
| Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/10868 http://dx.doi.org/10.1590/0004-282x20170076 |
| Resumo: | O edema cerebral e a hipertensão intracraniana (HIC) são as principais causas de morbidade e mortalidade de pacientes com insuficiência hepática fulminante (IHF). A patogênese dessas complicações tem sido investigada no homem, em modelos experimentais e em sistemas celulares isolados. Atualmente, o mecanismo subjacente ao edema cerebral e HIC na presença de IHF é multifatorial em etiologia e pouco compreendido na literatura. O objetivo deste trabalho é revisar a fisiopatologia das alterações hemodinâmicas e metabólicas cerebrais na IHF, visando melhorar a compreensão da complicação da hemodinâmica encefálica na IHF. |
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2019-04-04T17:54:37Z2019-04-04T17:54:37Z2017-07PASCHOAL JUNIOR, Fernando Mendes et al. Cerebral hemodynamic and metabolic changes in fulminant hepatic failure. Arquivos de Neuro-Psiquiatria, São Paulo, v. 75, n. 7, p. 470-476, jul. 2017. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10868. Acesso em:.1678-4227http://repositorio.ufpa.br/jspui/handle/2011/10868http://dx.doi.org/10.1590/0004-282x20170076O edema cerebral e a hipertensão intracraniana (HIC) são as principais causas de morbidade e mortalidade de pacientes com insuficiência hepática fulminante (IHF). A patogênese dessas complicações tem sido investigada no homem, em modelos experimentais e em sistemas celulares isolados. Atualmente, o mecanismo subjacente ao edema cerebral e HIC na presença de IHF é multifatorial em etiologia e pouco compreendido na literatura. O objetivo deste trabalho é revisar a fisiopatologia das alterações hemodinâmicas e metabólicas cerebrais na IHF, visando melhorar a compreensão da complicação da hemodinâmica encefálica na IHF.Intracranial hypertension and brain swelling are a major cause of morbidity and mortality of patients suffering from fulminant hepatic failure (FHF). The pathogenesis of these complications has been investigated in man, in experimental models and in isolated cell systems. Currently, the mechanism underlying cerebral edema and intracranial hypertension in the presence of FHF is multi-factorial in etiology and only partially understood. The aim of this paper is to review the pathophysiology of cerebral hemodynamic and metabolism changes in FHF in order to improve understanding of intracranial dynamics complication in FHF.PASCHOAL, E. H. A. Universidade Federal do ParáengUniversidade Federal do ParáUFPABrasilArquivos de Neuro-Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000700470&lng=pt&nrm=isoreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAHepatic insufficiencyIntracranial hypertensionBrain edemaInsuficiência hepaticaHipertenção intracranianaEdema encefálicoCerebral hemodynamic and metabolic changes in fulminant hepatic failureModificações da hemodinâmica e metabolismo cerebral na insuficiência hepatica fulminanteinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://lattes.cnpq.br/0171195401629428http://lattes.cnpq.br/3346878944545426http://lattes.cnpq.br/2380643845040755http://lattes.cnpq.br/1593548343125421http://lattes.cnpq.br/3622611451617494http://lattes.cnpq.br/3456781077547136http://lattes.cnpq.br/9379461873227909PASCHOAL JUNIOR, Fernando MendesNOGUEIRA, Ricardo de CarvalhoOLIVEIRA, Marcelo de LimaPASCHOAL, Eric Homero AlbuquerqueTEIXEIRA, Manoel JacobsenD’ALBUQUERQUE, Luiz Augusto CarneiroEdson Bor-Seng-Shuinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| dc.title.alternative.pt_BR.fl_str_mv |
Modificações da hemodinâmica e metabolismo cerebral na insuficiência hepatica fulminante |
| title |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| spellingShingle |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure Cerebral hemodynamic and metabolic changes in fulminant hepatic failure PASCHOAL JUNIOR, Fernando Mendes Hepatic insufficiency Intracranial hypertension Brain edema Insuficiência hepatica Hipertenção intracraniana Edema encefálico PASCHOAL JUNIOR, Fernando Mendes Hepatic insufficiency Intracranial hypertension Brain edema Insuficiência hepatica Hipertenção intracraniana Edema encefálico |
| title_short |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| title_full |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| title_fullStr |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| title_full_unstemmed |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| title_sort |
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure |
| author |
PASCHOAL JUNIOR, Fernando Mendes |
| author_facet |
PASCHOAL JUNIOR, Fernando Mendes PASCHOAL JUNIOR, Fernando Mendes NOGUEIRA, Ricardo de Carvalho OLIVEIRA, Marcelo de Lima PASCHOAL, Eric Homero Albuquerque TEIXEIRA, Manoel Jacobsen D’ALBUQUERQUE, Luiz Augusto Carneiro Edson Bor-Seng-Shu NOGUEIRA, Ricardo de Carvalho OLIVEIRA, Marcelo de Lima PASCHOAL, Eric Homero Albuquerque TEIXEIRA, Manoel Jacobsen D’ALBUQUERQUE, Luiz Augusto Carneiro Edson Bor-Seng-Shu |
| author_role |
author |
| author2 |
NOGUEIRA, Ricardo de Carvalho OLIVEIRA, Marcelo de Lima PASCHOAL, Eric Homero Albuquerque TEIXEIRA, Manoel Jacobsen D’ALBUQUERQUE, Luiz Augusto Carneiro Edson Bor-Seng-Shu |
| author2_role |
author author author author author author |
| dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0171195401629428 http://lattes.cnpq.br/3346878944545426 http://lattes.cnpq.br/2380643845040755 http://lattes.cnpq.br/1593548343125421 http://lattes.cnpq.br/3622611451617494 http://lattes.cnpq.br/3456781077547136 http://lattes.cnpq.br/9379461873227909 |
| dc.contributor.author.fl_str_mv |
PASCHOAL JUNIOR, Fernando Mendes NOGUEIRA, Ricardo de Carvalho OLIVEIRA, Marcelo de Lima PASCHOAL, Eric Homero Albuquerque TEIXEIRA, Manoel Jacobsen D’ALBUQUERQUE, Luiz Augusto Carneiro Edson Bor-Seng-Shu |
| dc.subject.por.fl_str_mv |
Hepatic insufficiency Intracranial hypertension Brain edema Insuficiência hepatica Hipertenção intracraniana Edema encefálico |
| topic |
Hepatic insufficiency Intracranial hypertension Brain edema Insuficiência hepatica Hipertenção intracraniana Edema encefálico |
| description |
O edema cerebral e a hipertensão intracraniana (HIC) são as principais causas de morbidade e mortalidade de pacientes com insuficiência hepática fulminante (IHF). A patogênese dessas complicações tem sido investigada no homem, em modelos experimentais e em sistemas celulares isolados. Atualmente, o mecanismo subjacente ao edema cerebral e HIC na presença de IHF é multifatorial em etiologia e pouco compreendido na literatura. O objetivo deste trabalho é revisar a fisiopatologia das alterações hemodinâmicas e metabólicas cerebrais na IHF, visando melhorar a compreensão da complicação da hemodinâmica encefálica na IHF. |
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2017 |
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2017-07 |
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2019-04-04T17:54:37Z |
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2019-04-04T17:54:37Z |
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PASCHOAL JUNIOR, Fernando Mendes et al. Cerebral hemodynamic and metabolic changes in fulminant hepatic failure. Arquivos de Neuro-Psiquiatria, São Paulo, v. 75, n. 7, p. 470-476, jul. 2017. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10868. Acesso em:. |
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1678-4227 |
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http://dx.doi.org/10.1590/0004-282x20170076 |
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PASCHOAL JUNIOR, Fernando Mendes et al. Cerebral hemodynamic and metabolic changes in fulminant hepatic failure. Arquivos de Neuro-Psiquiatria, São Paulo, v. 75, n. 7, p. 470-476, jul. 2017. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/10868. Acesso em:. 1678-4227 |
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Brasil |
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