Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/3438 |
Resumo: | Human serum paraoxonase (PON1) is an esterase associated with high density lipoproteins (HDLs) in the plasma and may confer protection against coronary artery disease. Serum PON1 levels and activity vary widely among individuals and populations of different ethnic groups, such variations appearing to be related to two coding region polymorphisms (L55M and Q192R). Several independent studies have indicated that the polymorphism at codon 192 (the R form) is a significant risk factor for cardiovascular disease in some populations, although this association has not been confirmed in other populations. Given the possible associations of these mutations with heart diseases and the fact that little or nothing is known of their prevalence in Amerindian populations, we investigated the variability of both polymorphisms in ten Amazonian Indian tribes and compared the variation found with that of other Asian populations in which both polymorphisms have been investigated. The results show that the LR haplotype is the most frequent and the MR haplotype is absent in all Amerindians and Asian populations. We also found that South America Amerindians present the highest frequency of the PON1192*R allele (considered a significant risk factor for heart diseases in some populations) of all the Amerindian and Asian populations so far studied. |
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2013-02-05T12:26:43Z2013-02-05T12:26:43Z2005-03SANTOS, Ney Pereira Carneiro dos; RIBEIRO-DOS-SANTOS, Ândrea KC; SANTOS, Sidney EB. Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes. Genetics and Molecular Biology. São Paulo, v. 28, n. 1, p. 36-39, jan./mar. 2005. Disponível em <http://www.scielo.br/pdf/gmb/v28n1/a06v28n1.pdf>. Acesso em: 01 fev. 2013. <http://dx.doi.org/10.1590/S1415-47572005000100006>.1415-4757http://repositorio.ufpa.br/jspui/handle/2011/3438Human serum paraoxonase (PON1) is an esterase associated with high density lipoproteins (HDLs) in the plasma and may confer protection against coronary artery disease. Serum PON1 levels and activity vary widely among individuals and populations of different ethnic groups, such variations appearing to be related to two coding region polymorphisms (L55M and Q192R). Several independent studies have indicated that the polymorphism at codon 192 (the R form) is a significant risk factor for cardiovascular disease in some populations, although this association has not been confirmed in other populations. Given the possible associations of these mutations with heart diseases and the fact that little or nothing is known of their prevalence in Amerindian populations, we investigated the variability of both polymorphisms in ten Amazonian Indian tribes and compared the variation found with that of other Asian populations in which both polymorphisms have been investigated. The results show that the LR haplotype is the most frequent and the MR haplotype is absent in all Amerindians and Asian populations. We also found that South America Amerindians present the highest frequency of the PON1192*R allele (considered a significant risk factor for heart diseases in some populations) of all the Amerindian and Asian populations so far studied.engSoro humano paraoxonaseGenética de populaçõesPolimorfismo genéticoÍndioAmazônia brasileiraFrequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSANTOS, Ney Pereira Carneiro dosSANTOS, Ândrea Kely Campos Ribeiro dosSANTOS, Sidney Emanuel Batista dosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAORIGINALArtigo_ FrequencyQ192R.pdfArtigo_ FrequencyQ192R.pdfapplication/pdf235163http://repositorio.ufpa.br/oai/bitstream/2011/3438/1/Artigo_%20FrequencyQ192R.pdf5a1c622359618f7e70c541d6798d812fMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/3438/2/license_urlfd26723f8d7edacdb29e3f03465c3b03MD52license_textlicense_texttext/html; charset=utf-80http://repositorio.ufpa.br/oai/bitstream/2011/3438/3/license_textd41d8cd98f00b204e9800998ecf8427eMD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-823599http://repositorio.ufpa.br/oai/bitstream/2011/3438/4/license_rdf9e2b7f6edbd693264102b96ece20428aMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81996http://repositorio.ufpa.br/oai/bitstream/2011/3438/5/license.txt4b350777eea7a4b1ae7cd9a06fd687a1MD55TEXTArtigo_ FrequencyQ192R.pdf.txtArtigo_ FrequencyQ192R.pdf.txtExtracted texttext/plain19270http://repositorio.ufpa.br/oai/bitstream/2011/3438/6/Artigo_%20FrequencyQ192R.pdf.txt95cebbf5924fb5972233babe06940e38MD562011/34382019-05-23 08:11:45.535oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232019-05-23T11:11:45Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.pt_BR.fl_str_mv |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
title |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
spellingShingle |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes SANTOS, Ney Pereira Carneiro dos Soro humano paraoxonase Genética de populações Polimorfismo genético Índio Amazônia brasileira |
title_short |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
title_full |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
title_fullStr |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
title_full_unstemmed |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
title_sort |
Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes |
author |
SANTOS, Ney Pereira Carneiro dos |
author_facet |
SANTOS, Ney Pereira Carneiro dos SANTOS, Ândrea Kely Campos Ribeiro dos SANTOS, Sidney Emanuel Batista dos |
author_role |
author |
author2 |
SANTOS, Ândrea Kely Campos Ribeiro dos SANTOS, Sidney Emanuel Batista dos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
SANTOS, Ney Pereira Carneiro dos SANTOS, Ândrea Kely Campos Ribeiro dos SANTOS, Sidney Emanuel Batista dos |
dc.subject.por.fl_str_mv |
Soro humano paraoxonase Genética de populações Polimorfismo genético Índio Amazônia brasileira |
topic |
Soro humano paraoxonase Genética de populações Polimorfismo genético Índio Amazônia brasileira |
description |
Human serum paraoxonase (PON1) is an esterase associated with high density lipoproteins (HDLs) in the plasma and may confer protection against coronary artery disease. Serum PON1 levels and activity vary widely among individuals and populations of different ethnic groups, such variations appearing to be related to two coding region polymorphisms (L55M and Q192R). Several independent studies have indicated that the polymorphism at codon 192 (the R form) is a significant risk factor for cardiovascular disease in some populations, although this association has not been confirmed in other populations. Given the possible associations of these mutations with heart diseases and the fact that little or nothing is known of their prevalence in Amerindian populations, we investigated the variability of both polymorphisms in ten Amazonian Indian tribes and compared the variation found with that of other Asian populations in which both polymorphisms have been investigated. The results show that the LR haplotype is the most frequent and the MR haplotype is absent in all Amerindians and Asian populations. We also found that South America Amerindians present the highest frequency of the PON1192*R allele (considered a significant risk factor for heart diseases in some populations) of all the Amerindian and Asian populations so far studied. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005-03 |
dc.date.accessioned.fl_str_mv |
2013-02-05T12:26:43Z |
dc.date.available.fl_str_mv |
2013-02-05T12:26:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Ney Pereira Carneiro dos; RIBEIRO-DOS-SANTOS, Ândrea KC; SANTOS, Sidney EB. Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes. Genetics and Molecular Biology. São Paulo, v. 28, n. 1, p. 36-39, jan./mar. 2005. Disponível em <http://www.scielo.br/pdf/gmb/v28n1/a06v28n1.pdf>. Acesso em: 01 fev. 2013. <http://dx.doi.org/10.1590/S1415-47572005000100006>. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/3438 |
dc.identifier.issn.none.fl_str_mv |
1415-4757 |
identifier_str_mv |
SANTOS, Ney Pereira Carneiro dos; RIBEIRO-DOS-SANTOS, Ândrea KC; SANTOS, Sidney EB. Frequency of the Q192R and L55M polymorphisms of the human serum paraoxonase gene (PON1) in ten Amazonian Amerindian tribes. Genetics and Molecular Biology. São Paulo, v. 28, n. 1, p. 36-39, jan./mar. 2005. Disponível em <http://www.scielo.br/pdf/gmb/v28n1/a06v28n1.pdf>. Acesso em: 01 fev. 2013. <http://dx.doi.org/10.1590/S1415-47572005000100006>. 1415-4757 |
url |
http://repositorio.ufpa.br/jspui/handle/2011/3438 |
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eng |
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eng |
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