Influence of oophorectomy on glycemia and lipidogram

• Autor(a) principal: TEIXEIRA, Renan Kleber Costa
• Data de Publicação: 2018
• Outros Autores: FEIJÓ, Daniel Haber, VALENTE, André Lopes, CARVALHO, Luan Teles Ferreira de, GRANHEN, Hícaro Donato, PETROIANU, Andy, BOTELHO, Nara Macedo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFPA
• Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/10797; http://dx.doi.org/10.1590/s0102-865020180050000003
• topic: Ovariectomy; Climacteric; Dyslipidemias; Rats

Methods:Fifty six female rats were divided into the following 7 groups (n = 8): group 1 - sham group, group 2 - oophorectomy 30 days, group 3 - oophorectomy 35 days, group 4 - oophorectomy 40 days, group 5 - oophorectomy 45 days, group 6 - oophorectomy 70 days, group 7 - oophorectomy 55 days. Animals were following by number of days according the group. Was evaluated the serum levels of glucose and lipid profile. Results: The oophorectomized rats presented higher glycemia. Groups 3, 4, 6 and 7 had a higher glycemia and LDL levels (except for group 6) and groups 6 and 7 had lowest levels of HDL. Group 7 had highest level of VLDL than oophorectomy groups. There was no difference in triglycerides levels. Conclusion: Oophorectomy was related to dyslipidemia and insulin resistance, mainly after 50th days.