Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach

Detalhes bibliográficos
Autor(a) principal: MARINHO, Andrey Moacir do Rosário
Data de Publicação: 2005
Outros Autores: RODRIGUES FILHO, Edson, MOITINHO, Maria da Luz Ribeiro, SANTOS, Lourivaldo da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
DOI: 10.1590/S0103-50532005000200023
Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/6974
Resumo: Penicillium janthinellum, isolado como um fungo endofítico dos frutos de Melia azedarach, foi cultivado por 20 dias em milho branco triturado e autoclavado, onde os policetídeos conhecidos citrinina, emodina, 1,6,8-triidróxi-3-hidroximetilantraquinona, e uma nova antraquinona modificada, denominada janthinona, foram produzidos e isolados por procedimentos cromatográficos clássicos e identificados por extensivos estudos espectroscópicos, principalmente RMN 1D e 2D e EM. Essas substâncias foram ensaiadas contra diversas bactérias. Citrinina foi ensaiada pela primeira vez contra Leishmania e inibiu 100% o crescimento de cepas depois de 48h a uma concentração de 40 μg mL-1.
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spelling 2015-11-09T16:27:12Z2015-11-09T16:27:12Z2005-04MARINHO, Andrey Moacir do Rosario et al. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. Journal of the Brazilian Chemical Society, São Paulo, v. 16, n. 2, p. 280-283, abr. 2005. Disponível em: <http://www.scielo.br/pdf/jbchs/v16n2/en_a23v16n2.pdf>. Acesso em: 6 nov. 2015. <http://dx.doi.org/10.1590/S0103-50532005000200023>.1678-4790http://repositorio.ufpa.br/jspui/handle/2011/6974Penicillium janthinellum, isolado como um fungo endofítico dos frutos de Melia azedarach, foi cultivado por 20 dias em milho branco triturado e autoclavado, onde os policetídeos conhecidos citrinina, emodina, 1,6,8-triidróxi-3-hidroximetilantraquinona, e uma nova antraquinona modificada, denominada janthinona, foram produzidos e isolados por procedimentos cromatográficos clássicos e identificados por extensivos estudos espectroscópicos, principalmente RMN 1D e 2D e EM. Essas substâncias foram ensaiadas contra diversas bactérias. Citrinina foi ensaiada pela primeira vez contra Leishmania e inibiu 100% o crescimento de cepas depois de 48h a uma concentração de 40 μg mL-1.Penicillium janthinellum, isolated as an endophytic fungus from fruits of Melia azedarach, was cultivated over 20 days on ground and autoclaved white corn, where the known polyketides citrinin, emodin, 1,6,8-trihydroxy-3-hydroxymethylanthraquinone, and a new modified anthraquinone, named janthinone, were produced and isolated by classical chromatographic procedures and identified by MS and 1D and 2D NMR spectroscopic data. The antibacterial properties of these polyketides were investigated. 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dc.title.pt_BR.fl_str_mv Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
title Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
spellingShingle Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
MARINHO, Andrey Moacir do Rosário
Espectroscopia
Fungo endofítico
Melia azedarach
Leishmania
Policetídeos
MARINHO, Andrey Moacir do Rosário
Espectroscopia
Fungo endofítico
Melia azedarach
Leishmania
Policetídeos
title_short Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
title_full Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
title_fullStr Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
title_full_unstemmed Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
title_sort Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach
author MARINHO, Andrey Moacir do Rosário
author_facet MARINHO, Andrey Moacir do Rosário
MARINHO, Andrey Moacir do Rosário
RODRIGUES FILHO, Edson
MOITINHO, Maria da Luz Ribeiro
SANTOS, Lourivaldo da Silva
RODRIGUES FILHO, Edson
MOITINHO, Maria da Luz Ribeiro
SANTOS, Lourivaldo da Silva
author_role author
author2 RODRIGUES FILHO, Edson
MOITINHO, Maria da Luz Ribeiro
SANTOS, Lourivaldo da Silva
author2_role author
author
author
dc.contributor.author.fl_str_mv MARINHO, Andrey Moacir do Rosário
RODRIGUES FILHO, Edson
MOITINHO, Maria da Luz Ribeiro
SANTOS, Lourivaldo da Silva
dc.subject.por.fl_str_mv Espectroscopia
Fungo endofítico
Melia azedarach
Leishmania
Policetídeos
topic Espectroscopia
Fungo endofítico
Melia azedarach
Leishmania
Policetídeos
description Penicillium janthinellum, isolado como um fungo endofítico dos frutos de Melia azedarach, foi cultivado por 20 dias em milho branco triturado e autoclavado, onde os policetídeos conhecidos citrinina, emodina, 1,6,8-triidróxi-3-hidroximetilantraquinona, e uma nova antraquinona modificada, denominada janthinona, foram produzidos e isolados por procedimentos cromatográficos clássicos e identificados por extensivos estudos espectroscópicos, principalmente RMN 1D e 2D e EM. Essas substâncias foram ensaiadas contra diversas bactérias. Citrinina foi ensaiada pela primeira vez contra Leishmania e inibiu 100% o crescimento de cepas depois de 48h a uma concentração de 40 μg mL-1.
publishDate 2005
dc.date.issued.fl_str_mv 2005-04
dc.date.accessioned.fl_str_mv 2015-11-09T16:27:12Z
dc.date.available.fl_str_mv 2015-11-09T16:27:12Z
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dc.identifier.citation.fl_str_mv MARINHO, Andrey Moacir do Rosario et al. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. Journal of the Brazilian Chemical Society, São Paulo, v. 16, n. 2, p. 280-283, abr. 2005. Disponível em: <http://www.scielo.br/pdf/jbchs/v16n2/en_a23v16n2.pdf>. Acesso em: 6 nov. 2015. <http://dx.doi.org/10.1590/S0103-50532005000200023>.
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identifier_str_mv MARINHO, Andrey Moacir do Rosario et al. Biologically active polyketides produced by Penicillium janthinellum isolated as an endophytic fungus from fruits of Melia azedarach. Journal of the Brazilian Chemical Society, São Paulo, v. 16, n. 2, p. 280-283, abr. 2005. Disponível em: <http://www.scielo.br/pdf/jbchs/v16n2/en_a23v16n2.pdf>. Acesso em: 6 nov. 2015. <http://dx.doi.org/10.1590/S0103-50532005000200023>.
1678-4790
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