Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients

Detalhes bibliográficos
Autor(a) principal: PIRES, Carla Andréa Avelar
Data de Publicação: 2015
Outros Autores: MIRANDA, Mario Fernando Ribeiro de, BITTENCOURT, Maraya de Jesus Semblano, BRITO, Arival Cardoso de, XAVIER, Marília Brasil
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/6517
Resumo: BACKGROUND: Leprosy and HIV are diseases that have a major impact on public health in Brazil. Patients coinfected with both diseases, appear to be at higher risk to develop leprosy reactions. OBJECTIVE: The aim of this study is to describe the histopathological aspects of cutaneous lesions during reactional states in a group of patients with HIV-leprosy coinfection, compared to patients with leprosy, without coinfection. METHODS: Two groups were established: group 1 comprised of 40 patients coinfected with HIV-leprosy; group 2, comprised of 107 patients with leprosy only. Patients presenting reactional states of leprosy had their lesions biopsied and comparatively evaluated. RESULTS: Reversal reaction was the most frequent feature in both groups, with dermis edema as the most common histopathological finding. Giant cells were seen in all group 1 histopathological examinations. Dermis edema was the most common finding in patients with erythema nodosum leprosum. CONCLUSION: Few histopathological differences were found in both groups, with reversal reaction as the most significant one, although this fact should be analyzed considering the predominant BT clinical form in the coinfected group and BB form in the group without HIV. Larger prospective studies in patients with HIV-leprosy coinfection are needed to confirm and broaden these results.
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spelling 2015-04-01T14:32:22Z2015-04-01T14:32:22Z2015-02PIRES, Carla Andréa Avelar et al. Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients. Anais Brasileiros de Dermatologia, Rio de Janeiro, v. 90, n. 1, p. 27-34, jan./fev. 2015. Disponível em: <http://www.scielo.br/pdf/abd/v90n1/0365-0596-abd-90-01-0027.pdf>. Acesso em: 31 mar. 2015. <http://dx.doi.org/10.1590/abd1806-4841.20153048>.1806-4841http://repositorio.ufpa.br/jspui/handle/2011/6517BACKGROUND: Leprosy and HIV are diseases that have a major impact on public health in Brazil. Patients coinfected with both diseases, appear to be at higher risk to develop leprosy reactions. OBJECTIVE: The aim of this study is to describe the histopathological aspects of cutaneous lesions during reactional states in a group of patients with HIV-leprosy coinfection, compared to patients with leprosy, without coinfection. METHODS: Two groups were established: group 1 comprised of 40 patients coinfected with HIV-leprosy; group 2, comprised of 107 patients with leprosy only. Patients presenting reactional states of leprosy had their lesions biopsied and comparatively evaluated. RESULTS: Reversal reaction was the most frequent feature in both groups, with dermis edema as the most common histopathological finding. Giant cells were seen in all group 1 histopathological examinations. Dermis edema was the most common finding in patients with erythema nodosum leprosum. CONCLUSION: Few histopathological differences were found in both groups, with reversal reaction as the most significant one, although this fact should be analyzed considering the predominant BT clinical form in the coinfected group and BB form in the group without HIV. Larger prospective studies in patients with HIV-leprosy coinfection are needed to confirm and broaden these results.engHistologiaHanseníaseHIV (Vírus)CoinfecçãoBrasil - PaísDoenças infecciosasComparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePIRES, Carla Andréa AvelarMIRANDA, Mario Fernando Ribeiro deBITTENCOURT, Maraya de Jesus SemblanoBRITO, Arival Cardoso deXAVIER, Marília Brasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAORIGINALArtigo_ComparisonBetweenHistopathologic.pdfArtigo_ComparisonBetweenHistopathologic.pdfapplication/pdf189814http://repositorio.ufpa.br/oai/bitstream/2011/6517/1/Artigo_ComparisonBetweenHistopathologic.pdf497687f22d5fb679437d6a5deaae4adeMD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/6517/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-822376http://repositorio.ufpa.br/oai/bitstream/2011/6517/3/license_textd4b12fbc55dda86e4a445686ff8a56f3MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-822190http://repositorio.ufpa.br/oai/bitstream/2011/6517/4/license_rdf19e8a2b57ef43c09f4d7071d2153c97dMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81703http://repositorio.ufpa.br/oai/bitstream/2011/6517/5/license.txta12ee01655d4f43dacf016d5e6168febMD55TEXTArtigo_ComparisonBetweenHistopathologic.pdf.txtArtigo_ComparisonBetweenHistopathologic.pdf.txtExtracted texttext/plain32685http://repositorio.ufpa.br/oai/bitstream/2011/6517/6/Artigo_ComparisonBetweenHistopathologic.pdf.txt3cfb359df2ee2cf0c8f5d556837aafa4MD562011/65172017-12-14 10:26:23.55oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232017-12-14T13:26:23Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false
dc.title.pt_BR.fl_str_mv Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
spellingShingle Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
PIRES, Carla Andréa Avelar
Histologia
Hanseníase
HIV (Vírus)
Coinfecção
Brasil - País
Doenças infecciosas
title_short Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_full Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_fullStr Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_full_unstemmed Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
title_sort Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients
author PIRES, Carla Andréa Avelar
author_facet PIRES, Carla Andréa Avelar
MIRANDA, Mario Fernando Ribeiro de
BITTENCOURT, Maraya de Jesus Semblano
BRITO, Arival Cardoso de
XAVIER, Marília Brasil
author_role author
author2 MIRANDA, Mario Fernando Ribeiro de
BITTENCOURT, Maraya de Jesus Semblano
BRITO, Arival Cardoso de
XAVIER, Marília Brasil
author2_role author
author
author
author
dc.contributor.author.fl_str_mv PIRES, Carla Andréa Avelar
MIRANDA, Mario Fernando Ribeiro de
BITTENCOURT, Maraya de Jesus Semblano
BRITO, Arival Cardoso de
XAVIER, Marília Brasil
dc.subject.por.fl_str_mv Histologia
Hanseníase
HIV (Vírus)
Coinfecção
Brasil - País
Doenças infecciosas
topic Histologia
Hanseníase
HIV (Vírus)
Coinfecção
Brasil - País
Doenças infecciosas
description BACKGROUND: Leprosy and HIV are diseases that have a major impact on public health in Brazil. Patients coinfected with both diseases, appear to be at higher risk to develop leprosy reactions. OBJECTIVE: The aim of this study is to describe the histopathological aspects of cutaneous lesions during reactional states in a group of patients with HIV-leprosy coinfection, compared to patients with leprosy, without coinfection. METHODS: Two groups were established: group 1 comprised of 40 patients coinfected with HIV-leprosy; group 2, comprised of 107 patients with leprosy only. Patients presenting reactional states of leprosy had their lesions biopsied and comparatively evaluated. RESULTS: Reversal reaction was the most frequent feature in both groups, with dermis edema as the most common histopathological finding. Giant cells were seen in all group 1 histopathological examinations. Dermis edema was the most common finding in patients with erythema nodosum leprosum. CONCLUSION: Few histopathological differences were found in both groups, with reversal reaction as the most significant one, although this fact should be analyzed considering the predominant BT clinical form in the coinfected group and BB form in the group without HIV. Larger prospective studies in patients with HIV-leprosy coinfection are needed to confirm and broaden these results.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-04-01T14:32:22Z
dc.date.available.fl_str_mv 2015-04-01T14:32:22Z
dc.date.issued.fl_str_mv 2015-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv PIRES, Carla Andréa Avelar et al. Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients. Anais Brasileiros de Dermatologia, Rio de Janeiro, v. 90, n. 1, p. 27-34, jan./fev. 2015. Disponível em: <http://www.scielo.br/pdf/abd/v90n1/0365-0596-abd-90-01-0027.pdf>. Acesso em: 31 mar. 2015. <http://dx.doi.org/10.1590/abd1806-4841.20153048>.
dc.identifier.uri.fl_str_mv http://repositorio.ufpa.br/jspui/handle/2011/6517
dc.identifier.issn.none.fl_str_mv 1806-4841
identifier_str_mv PIRES, Carla Andréa Avelar et al. Comparison between histopathologic features of leprosy in reaction lesions in HIV coinfected and non-coinfected patients. Anais Brasileiros de Dermatologia, Rio de Janeiro, v. 90, n. 1, p. 27-34, jan./fev. 2015. Disponível em: <http://www.scielo.br/pdf/abd/v90n1/0365-0596-abd-90-01-0027.pdf>. Acesso em: 31 mar. 2015. <http://dx.doi.org/10.1590/abd1806-4841.20153048>.
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