Immediate graft histological assay, post pig's liver transplantation

Detalhes bibliográficos
Autor(a) principal: BRITO, Marcus Vinicius Henriques
Data de Publicação: 2013
Outros Autores: ARAÚJO, Marialva Tereza Ferreira de, CUNHA, Luane Cristine Batista, OLIVEIRA, Antônio Jorge Barbosa de, RODRIGUES, Jacqueline Barreto, BRITO, Nathalya Botelho, https://orcid.org/0000-0003-1476-0054
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFPA
Texto Completo: http://repositorio.ufpa.br/jspui/handle/2011/6346
http://dx.doi.org/10.1590/S0102-86502013000900009
Resumo: PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.
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spelling 2015-02-25T14:46:28Z2015-02-25T14:46:28Z2013-09BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:.1678-2674http://repositorio.ufpa.br/jspui/handle/2011/6346http://dx.doi.org/10.1590/S0102-86502013000900009PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoARAÚJO, M. T. F.; CUNHA, L. C. B. Universidade Federal do ParáengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaSOBRADPECBrasilActa Cirúrgica Brasileirahttp://ref.scielo.org/hrprb7reponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAHistologiaTransplante de fígadoSuínoLiver transplantationHistologySwineImmediate graft histological assay, post pig's liver transplantationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article289678682http://lattes.cnpq.br/1180984403274256http://lattes.cnpq.br/6779304013585161http://lattes.cnpq.br/4584101245176132http://lattes.cnpq.br/0411429547091012http://lattes.cnpqhttp://lattes.cnpq.br/0854226571201605BRITO, Marcus Vinicius HenriquesARAÚJO, Marialva Tereza Ferreira deCUNHA, Luane Cristine BatistaOLIVEIRA, Antônio Jorge Barbosa deRODRIGUES, Jacqueline BarretoBRITO, Nathalya Botelhohttps://orcid.org/0000-0003-1476-0054info:eu-repo/semantics/openAccessORIGINALArticle_ImmediateGraftHistological.pdfArticle_ImmediateGraftHistological.pdfapplication/pdf1531528http://repositorio.ufpa.br/oai/bitstream/2011/6346/1/Article_ImmediateGraftHistological.pdfdbf7e54880a246ee7a1e7fc16e5fe876MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/6346/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-822376http://repositorio.ufpa.br/oai/bitstream/2011/6346/3/license_textd4b12fbc55dda86e4a445686ff8a56f3MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-822190http://repositorio.ufpa.br/oai/bitstream/2011/6346/4/license_rdf19e8a2b57ef43c09f4d7071d2153c97dMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81703http://repositorio.ufpa.br/oai/bitstream/2011/6346/5/license.txta12ee01655d4f43dacf016d5e6168febMD55TEXTArtigo_ImmediateGraftHistological.pdf.txtArtigo_ImmediateGraftHistological.pdf.txtExtracted texttext/plain22550http://repositorio.ufpa.br/oai/bitstream/2011/6346/6/Artigo_ImmediateGraftHistological.pdf.txtae17ef88e0289d0997de717c7c0051d0MD56Article_ImmediateGraftHistological.pdf.txtArticle_ImmediateGraftHistological.pdf.txtExtracted texttext/plain22550http://repositorio.ufpa.br/oai/bitstream/2011/6346/7/Article_ImmediateGraftHistological.pdf.txtae17ef88e0289d0997de717c7c0051d0MD572011/63462020-01-27 13:27:04.659oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232020-01-27T16:27:04Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false
dc.title.en.fl_str_mv Immediate graft histological assay, post pig's liver transplantation
title Immediate graft histological assay, post pig's liver transplantation
spellingShingle Immediate graft histological assay, post pig's liver transplantation
BRITO, Marcus Vinicius Henriques
Histologia
Transplante de fígado
Suíno
Liver transplantation
Histology
Swine
title_short Immediate graft histological assay, post pig's liver transplantation
title_full Immediate graft histological assay, post pig's liver transplantation
title_fullStr Immediate graft histological assay, post pig's liver transplantation
title_full_unstemmed Immediate graft histological assay, post pig's liver transplantation
title_sort Immediate graft histological assay, post pig's liver transplantation
author BRITO, Marcus Vinicius Henriques
author_facet BRITO, Marcus Vinicius Henriques
ARAÚJO, Marialva Tereza Ferreira de
CUNHA, Luane Cristine Batista
OLIVEIRA, Antônio Jorge Barbosa de
RODRIGUES, Jacqueline Barreto
BRITO, Nathalya Botelho
https://orcid.org/0000-0003-1476-0054
author_role author
author2 ARAÚJO, Marialva Tereza Ferreira de
CUNHA, Luane Cristine Batista
OLIVEIRA, Antônio Jorge Barbosa de
RODRIGUES, Jacqueline Barreto
BRITO, Nathalya Botelho
https://orcid.org/0000-0003-1476-0054
author2_role author
author
author
author
author
author
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1180984403274256
http://lattes.cnpq.br/6779304013585161
http://lattes.cnpq.br/4584101245176132
http://lattes.cnpq.br/0411429547091012
http://lattes.cnpq
http://lattes.cnpq.br/0854226571201605
dc.contributor.author.fl_str_mv BRITO, Marcus Vinicius Henriques
ARAÚJO, Marialva Tereza Ferreira de
CUNHA, Luane Cristine Batista
OLIVEIRA, Antônio Jorge Barbosa de
RODRIGUES, Jacqueline Barreto
BRITO, Nathalya Botelho
https://orcid.org/0000-0003-1476-0054
dc.subject.por.fl_str_mv Histologia
Transplante de fígado
Suíno
topic Histologia
Transplante de fígado
Suíno
Liver transplantation
Histology
Swine
dc.subject.eng.fl_str_mv Liver transplantation
Histology
Swine
description PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.
publishDate 2013
dc.date.issued.fl_str_mv 2013-09
dc.date.accessioned.fl_str_mv 2015-02-25T14:46:28Z
dc.date.available.fl_str_mv 2015-02-25T14:46:28Z
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dc.identifier.citation.fl_str_mv BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:.
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dc.identifier.issn.none.fl_str_mv 1678-2674
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S0102-86502013000900009
identifier_str_mv BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:.
1678-2674
url http://repositorio.ufpa.br/jspui/handle/2011/6346
http://dx.doi.org/10.1590/S0102-86502013000900009
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