Immediate graft histological assay, post pig's liver transplantation
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFPA |
Texto Completo: | http://repositorio.ufpa.br/jspui/handle/2011/6346 http://dx.doi.org/10.1590/S0102-86502013000900009 |
Resumo: | PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells. |
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2015-02-25T14:46:28Z2015-02-25T14:46:28Z2013-09BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:.1678-2674http://repositorio.ufpa.br/jspui/handle/2011/6346http://dx.doi.org/10.1590/S0102-86502013000900009PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoARAÚJO, M. T. F.; CUNHA, L. C. B. Universidade Federal do ParáengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaSOBRADPECBrasilActa Cirúrgica Brasileirahttp://ref.scielo.org/hrprb7reponame:Repositório Institucional da UFPAinstname:Universidade Federal do Pará (UFPA)instacron:UFPAHistologiaTransplante de fígadoSuínoLiver transplantationHistologySwineImmediate graft histological assay, post pig's liver transplantationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article289678682http://lattes.cnpq.br/1180984403274256http://lattes.cnpq.br/6779304013585161http://lattes.cnpq.br/4584101245176132http://lattes.cnpq.br/0411429547091012http://lattes.cnpqhttp://lattes.cnpq.br/0854226571201605BRITO, Marcus Vinicius HenriquesARAÚJO, Marialva Tereza Ferreira deCUNHA, Luane Cristine BatistaOLIVEIRA, Antônio Jorge Barbosa deRODRIGUES, Jacqueline BarretoBRITO, Nathalya Botelhohttps://orcid.org/0000-0003-1476-0054info:eu-repo/semantics/openAccessORIGINALArticle_ImmediateGraftHistological.pdfArticle_ImmediateGraftHistological.pdfapplication/pdf1531528http://repositorio.ufpa.br/oai/bitstream/2011/6346/1/Article_ImmediateGraftHistological.pdfdbf7e54880a246ee7a1e7fc16e5fe876MD51CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.ufpa.br/oai/bitstream/2011/6346/2/license_url4afdbb8c545fd630ea7db775da747b2fMD52license_textlicense_texttext/html; charset=utf-822376http://repositorio.ufpa.br/oai/bitstream/2011/6346/3/license_textd4b12fbc55dda86e4a445686ff8a56f3MD53license_rdflicense_rdfapplication/rdf+xml; charset=utf-822190http://repositorio.ufpa.br/oai/bitstream/2011/6346/4/license_rdf19e8a2b57ef43c09f4d7071d2153c97dMD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81703http://repositorio.ufpa.br/oai/bitstream/2011/6346/5/license.txta12ee01655d4f43dacf016d5e6168febMD55TEXTArtigo_ImmediateGraftHistological.pdf.txtArtigo_ImmediateGraftHistological.pdf.txtExtracted texttext/plain22550http://repositorio.ufpa.br/oai/bitstream/2011/6346/6/Artigo_ImmediateGraftHistological.pdf.txtae17ef88e0289d0997de717c7c0051d0MD56Article_ImmediateGraftHistological.pdf.txtArticle_ImmediateGraftHistological.pdf.txtExtracted texttext/plain22550http://repositorio.ufpa.br/oai/bitstream/2011/6346/7/Article_ImmediateGraftHistological.pdf.txtae17ef88e0289d0997de717c7c0051d0MD572011/63462020-01-27 13:27:04.659oai:repositorio.ufpa.br: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Repositório InstitucionalPUBhttp://repositorio.ufpa.br/oai/requestriufpabc@ufpa.bropendoar:21232020-01-27T16:27:04Repositório Institucional da UFPA - Universidade Federal do Pará (UFPA)false |
dc.title.en.fl_str_mv |
Immediate graft histological assay, post pig's liver transplantation |
title |
Immediate graft histological assay, post pig's liver transplantation |
spellingShingle |
Immediate graft histological assay, post pig's liver transplantation BRITO, Marcus Vinicius Henriques Histologia Transplante de fígado Suíno Liver transplantation Histology Swine |
title_short |
Immediate graft histological assay, post pig's liver transplantation |
title_full |
Immediate graft histological assay, post pig's liver transplantation |
title_fullStr |
Immediate graft histological assay, post pig's liver transplantation |
title_full_unstemmed |
Immediate graft histological assay, post pig's liver transplantation |
title_sort |
Immediate graft histological assay, post pig's liver transplantation |
author |
BRITO, Marcus Vinicius Henriques |
author_facet |
BRITO, Marcus Vinicius Henriques ARAÚJO, Marialva Tereza Ferreira de CUNHA, Luane Cristine Batista OLIVEIRA, Antônio Jorge Barbosa de RODRIGUES, Jacqueline Barreto BRITO, Nathalya Botelho https://orcid.org/0000-0003-1476-0054 |
author_role |
author |
author2 |
ARAÚJO, Marialva Tereza Ferreira de CUNHA, Luane Cristine Batista OLIVEIRA, Antônio Jorge Barbosa de RODRIGUES, Jacqueline Barreto BRITO, Nathalya Botelho https://orcid.org/0000-0003-1476-0054 |
author2_role |
author author author author author author |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1180984403274256 http://lattes.cnpq.br/6779304013585161 http://lattes.cnpq.br/4584101245176132 http://lattes.cnpq.br/0411429547091012 http://lattes.cnpq http://lattes.cnpq.br/0854226571201605 |
dc.contributor.author.fl_str_mv |
BRITO, Marcus Vinicius Henriques ARAÚJO, Marialva Tereza Ferreira de CUNHA, Luane Cristine Batista OLIVEIRA, Antônio Jorge Barbosa de RODRIGUES, Jacqueline Barreto BRITO, Nathalya Botelho https://orcid.org/0000-0003-1476-0054 |
dc.subject.por.fl_str_mv |
Histologia Transplante de fígado Suíno |
topic |
Histologia Transplante de fígado Suíno Liver transplantation Histology Swine |
dc.subject.eng.fl_str_mv |
Liver transplantation Histology Swine |
description |
PURPOSE: To describe the vascular and tissue histopathological changes in seven sequential experimental liver transplantations in pigs. METHODS: Fourteen female pigs, Sus domesticus species, with body mass between 5 and 8 kg were utilized. After the end of all anastomoses of the graft implantation in the receptor, the animal was monitored for 30 minutes, and at its end one of the biopsies was collected for histological analysis. The histological criteria utilized were: lytic hepatocyte necrosis, density of septal and portal inflammatory infiltrated, sinusoidal congestion and hemorrhage. The analysis was performed separately for the portal region in zone 1, 2 and 3. RESULTS: Among the structural changes undergone by the graft, those with greater frequency and intensity were vascular congestion and steatosis, which stood out in transplantations 5, 6 and 7. CONCLUSIONS: The technique demonstrated vascular alterations represented by vasocongestion, edema and minimum inflammatory reaction. In relation to the parenchyma, was observed macrovacuolar pan-acinar steatosis, focal lytic and occasional hemorrhages, beyond the accumulation of hemosiderin in Kuppfer's cells. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-09 |
dc.date.accessioned.fl_str_mv |
2015-02-25T14:46:28Z |
dc.date.available.fl_str_mv |
2015-02-25T14:46:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpa.br/jspui/handle/2011/6346 |
dc.identifier.issn.none.fl_str_mv |
1678-2674 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502013000900009 |
identifier_str_mv |
BRITO, Marcus Vinicius Henriques et al. Immediate graft histological assay, post pig's liver transplantation. Acta Cirúrgica Brasileira, São Paulo, v. 28, n. 9, p. 678-682, Sept. 2013. DOI: http://dx.doi.org/10.1590/S0102-86502013000900009. Disponível em: http://repositorio.ufpa.br/jspui/handle/2011/6346. Acesso em:. 1678-2674 |
url |
http://repositorio.ufpa.br/jspui/handle/2011/6346 http://dx.doi.org/10.1590/S0102-86502013000900009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Acta Cirúrgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
dc.publisher.initials.fl_str_mv |
SOBRADPEC |
dc.publisher.country.fl_str_mv |
Brasil |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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