Densidade de mastócitos em lesões de queilite actínica.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFPB |
Texto Completo: | https://repositorio.ufpb.br/jspui/handle/tede/6646 |
Resumo: | The objective of this study was to evaluate the density of mast cells in the lesions of actinic cheilitis and its correlation with the processes of inflammation and epithelial dysplasia. We selected 33 cases of actinic cheilitis recorded in the Department of Head and Neck Surgery, Hospital Dr. Laureano Napoleon, PB. The paraffin blocks were cut and stained with hematoxylin and eosin and toluidine blue. The count of mast cells was performed in 8 fields per case and final reading with the average value expressed. Analysis was descriptive and inferential statistics, and tests were applied to the Mann-Whitney U, Kuskall-Wallis test, chi-square and Spearman coefficient, considering p <0.05. Of the total sample, 57.6% had some degree of epithelial dysplasia, mild dysplasia was 39.4%, 15.2% moderate and 3% severe. In 21.2% of the sample was observed squamous cell carcinoma of the lip. The presence of solar elastosis was observed in 81.8% and some degree of inflammation in 84.9%, as well as 39.4% mild, 15.2% moderate and 30.3% intense. Mast cells were present in 87,8% of cases. The average number of mast cells in specimens of actinic cheilitis was 17.42 ± 10.43 cells / μm² and normal mucosa 1.78 ± 1.64 cells / μm², and this difference was statistically significant (p <0.001). The density of mast cells was significantly higher in cancer cases with p = 0.001. There was a statistically significant correlation between the density of mast cells and the processes of dysplasia (p = 0.004) and inflammatory cell infiltration (p = 0.000) and between epithelial dysplasia and inflammatory cell infiltration (p = 0.002). The increased density of mast cells suggests a possible role of these cells in the malignant transformation of the lesion. |
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Densidade de mastócitos em lesões de queilite actínica.MastócitosQueilite actínicaCarcinoma de células escamosasMast cellsActinic cheilitisSquamous cells carcinomaCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAThe objective of this study was to evaluate the density of mast cells in the lesions of actinic cheilitis and its correlation with the processes of inflammation and epithelial dysplasia. We selected 33 cases of actinic cheilitis recorded in the Department of Head and Neck Surgery, Hospital Dr. Laureano Napoleon, PB. The paraffin blocks were cut and stained with hematoxylin and eosin and toluidine blue. The count of mast cells was performed in 8 fields per case and final reading with the average value expressed. Analysis was descriptive and inferential statistics, and tests were applied to the Mann-Whitney U, Kuskall-Wallis test, chi-square and Spearman coefficient, considering p <0.05. Of the total sample, 57.6% had some degree of epithelial dysplasia, mild dysplasia was 39.4%, 15.2% moderate and 3% severe. In 21.2% of the sample was observed squamous cell carcinoma of the lip. The presence of solar elastosis was observed in 81.8% and some degree of inflammation in 84.9%, as well as 39.4% mild, 15.2% moderate and 30.3% intense. Mast cells were present in 87,8% of cases. The average number of mast cells in specimens of actinic cheilitis was 17.42 ± 10.43 cells / μm² and normal mucosa 1.78 ± 1.64 cells / μm², and this difference was statistically significant (p <0.001). The density of mast cells was significantly higher in cancer cases with p = 0.001. There was a statistically significant correlation between the density of mast cells and the processes of dysplasia (p = 0.004) and inflammatory cell infiltration (p = 0.000) and between epithelial dysplasia and inflammatory cell infiltration (p = 0.002). The increased density of mast cells suggests a possible role of these cells in the malignant transformation of the lesion.Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorO objetivo do estudo foi avaliar a densidade de mastócitos nas lesões de queilite actínica e sua correlação com os processos de inflamação e displasia epitelial, comparando a controle normal. Para o grupo queilite actínica, selecionaram-se 33 casos de registrados no Serviço de Cirurgia de Cabeça e Pescoço do Hospital do Napoleão Laureano, PB. E para o controle, 9 blocos com diagnóstico de mucocele Os blocos parafinados foram cortados e corados em Hematoxilina e Eosina e por Azul de toluidina. A contagem dos mastócitos foi realizada em 8 campos por espécimes. Realizou-se análise estatística descritiva e aplicaram-se testes U de Mann-Whitney, Kuskall-Wallis, Qui-Quadrado e o coeficiente de Spearman, considerando p<0,05. No grupo queilite actínica, 57,6% apresentaram algum grau de displasia epitelial, sendo 39,4% displasia leve, 15,2% moderada e 3% severa. Em 21,2% da amostra foi observado carcinoma de células escamosas de lábio. A presença de elastose solar foi observada em 81,8% dos casos e algum grau de inflamação em 84,9%, sendo 39,4% leve, 15,2% moderado e 30,3% intenso. Os mastócitos estavam presentes em 87,8% dos casos. A média de mastócitos no grupo queilite actínica foi de 17,42±10,43 células/μm² e no controle 1,78±1,64 células/μm², com diferença estatisticamente significante (p<0,001). A densidade dos mastócitos foi significativamente maior nos casos de carcinoma com p=0,001. Houve correlação estatisticamente significante entre densidade de mastócitos e os processos de displasia (p=0,004) e infiltrado inflamatório(p=0,000); e entre displasia epitelial e infiltrado inflamatório (p=0,002). O aumento da densidade dos mastócitos sugere uma possível participação dessas células no processo de transformação maligna da lesão.Universidade Federal da ParaíbaBROdontologiaPrograma de Pós Graduação em OdontologiaUFPBSoares, Maria Sueli Marqueshttp://lattes.cnpq.br/8594514894937279Lira, Claudia Cazalhttp://lattes.cnpq.br/2431240232490563Arnaud, Rachel Reinaldo2015-05-14T12:56:00Z2018-07-21T00:23:59Z2012-12-112018-07-21T00:23:59Z2011-12-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfARNAUD, Rachel Reinaldo. Densidade de mastócitos em lesões de queilite actínica.. 2011. 72 f. Dissertação (Mestrado em Odontologia) - Universidade Federal da Paraíba, João Pessoa, 2011.https://repositorio.ufpb.br/jspui/handle/tede/6646porinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFPBinstname:Universidade Federal da Paraíba (UFPB)instacron:UFPB2018-09-06T00:47:32Zoai:repositorio.ufpb.br:tede/6646Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufpb.br/PUBhttp://tede.biblioteca.ufpb.br:8080/oai/requestdiretoria@ufpb.br|| diretoria@ufpb.bropendoar:2018-09-06T00:47:32Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB)false |
dc.title.none.fl_str_mv |
Densidade de mastócitos em lesões de queilite actínica. |
title |
Densidade de mastócitos em lesões de queilite actínica. |
spellingShingle |
Densidade de mastócitos em lesões de queilite actínica. Arnaud, Rachel Reinaldo Mastócitos Queilite actínica Carcinoma de células escamosas Mast cells Actinic cheilitis Squamous cells carcinoma CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Densidade de mastócitos em lesões de queilite actínica. |
title_full |
Densidade de mastócitos em lesões de queilite actínica. |
title_fullStr |
Densidade de mastócitos em lesões de queilite actínica. |
title_full_unstemmed |
Densidade de mastócitos em lesões de queilite actínica. |
title_sort |
Densidade de mastócitos em lesões de queilite actínica. |
author |
Arnaud, Rachel Reinaldo |
author_facet |
Arnaud, Rachel Reinaldo |
author_role |
author |
dc.contributor.none.fl_str_mv |
Soares, Maria Sueli Marques http://lattes.cnpq.br/8594514894937279 Lira, Claudia Cazal http://lattes.cnpq.br/2431240232490563 |
dc.contributor.author.fl_str_mv |
Arnaud, Rachel Reinaldo |
dc.subject.por.fl_str_mv |
Mastócitos Queilite actínica Carcinoma de células escamosas Mast cells Actinic cheilitis Squamous cells carcinoma CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
topic |
Mastócitos Queilite actínica Carcinoma de células escamosas Mast cells Actinic cheilitis Squamous cells carcinoma CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
The objective of this study was to evaluate the density of mast cells in the lesions of actinic cheilitis and its correlation with the processes of inflammation and epithelial dysplasia. We selected 33 cases of actinic cheilitis recorded in the Department of Head and Neck Surgery, Hospital Dr. Laureano Napoleon, PB. The paraffin blocks were cut and stained with hematoxylin and eosin and toluidine blue. The count of mast cells was performed in 8 fields per case and final reading with the average value expressed. Analysis was descriptive and inferential statistics, and tests were applied to the Mann-Whitney U, Kuskall-Wallis test, chi-square and Spearman coefficient, considering p <0.05. Of the total sample, 57.6% had some degree of epithelial dysplasia, mild dysplasia was 39.4%, 15.2% moderate and 3% severe. In 21.2% of the sample was observed squamous cell carcinoma of the lip. The presence of solar elastosis was observed in 81.8% and some degree of inflammation in 84.9%, as well as 39.4% mild, 15.2% moderate and 30.3% intense. Mast cells were present in 87,8% of cases. The average number of mast cells in specimens of actinic cheilitis was 17.42 ± 10.43 cells / μm² and normal mucosa 1.78 ± 1.64 cells / μm², and this difference was statistically significant (p <0.001). The density of mast cells was significantly higher in cancer cases with p = 0.001. There was a statistically significant correlation between the density of mast cells and the processes of dysplasia (p = 0.004) and inflammatory cell infiltration (p = 0.000) and between epithelial dysplasia and inflammatory cell infiltration (p = 0.002). The increased density of mast cells suggests a possible role of these cells in the malignant transformation of the lesion. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-05 2012-12-11 2015-05-14T12:56:00Z 2018-07-21T00:23:59Z 2018-07-21T00:23:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ARNAUD, Rachel Reinaldo. Densidade de mastócitos em lesões de queilite actínica.. 2011. 72 f. Dissertação (Mestrado em Odontologia) - Universidade Federal da Paraíba, João Pessoa, 2011. https://repositorio.ufpb.br/jspui/handle/tede/6646 |
identifier_str_mv |
ARNAUD, Rachel Reinaldo. Densidade de mastócitos em lesões de queilite actínica.. 2011. 72 f. Dissertação (Mestrado em Odontologia) - Universidade Federal da Paraíba, João Pessoa, 2011. |
url |
https://repositorio.ufpb.br/jspui/handle/tede/6646 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal da Paraíba BR Odontologia Programa de Pós Graduação em Odontologia UFPB |
publisher.none.fl_str_mv |
Universidade Federal da Paraíba BR Odontologia Programa de Pós Graduação em Odontologia UFPB |
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Biblioteca Digital de Teses e Dissertações da UFPB |
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Biblioteca Digital de Teses e Dissertações da UFPB |
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Biblioteca Digital de Teses e Dissertações da UFPB - Universidade Federal da Paraíba (UFPB) |
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diretoria@ufpb.br|| diretoria@ufpb.br |
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