Avaliação da atividade antibacteriana de 2-oxo-2-feniletil benzoato frente à linhagens de Escherichia coli patogências e de origem hospitalar

• Autor(a) principal: Morais, Maria Franncielly Simões de
• Data de Publicação: 2021
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFPB
• Texto Completo: https://repositorio.ufpb.br/jspui/handle/123456789/22115
• topic: Escherichia coli; Atividade antibacteriana; Compostos orgânicos sintéticos; 2-oxo-2-feniletil benzoato; Derivados de brometo de fenacila; Antibacterial activity; Synthetic organic compounds; 2-oxo-2-phenylethyl benzoate; Phenacyl bromide derivative; CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA

Escherichia coli, belonging to the Enterobacteriaceae family, is a micro-organism of great importance to public health and due to its high recurrence in diseases, both in the hospital environment and in the community, it is one of the most researched species in the world. They have the ability to adapt and develop resistance to antibiotics, ranking third in the list of the “12 priority pathogens” resistant to antibiotics prepared by the World Health Organization. The incidence of these occurrences has increased over the decades, high mortality rates with occurrences There is an increasing need to find new substances with antimicrobial properties that are effective in combating these microorganisms. In this sense, synthetic organic compounds, an important source of new substances and have helped in the discovery of many therapies that improve, complement, human health. Therefore, this study evaluated the antibacterial activity of the 2-oxo-2-phenylethyl benzoate molecule against 15 clinical strains of Escherichia coli through in vitro assays. The antibacterial activity was evaluated through the determination of the Minimum Inhibitory Concentration (MIC), the Minimum Bactericidal Concentration (CBM) and studies of the association of the 2-oxo-2-phenylethyl benzoate molecule with a standard antibiotic (Imipenem) through the installation of the Index of the Fractional Inhibitory Concentration (ICIF). In the evaluation of antibacterial activity, a presenting substance CIM of 256 μg / mL and CBM of 1024 μg / mL. Therefore, an antibacterial activity of the test molecule can be considered as strong. The association of the 2-oxo-2- phenylethyl benzoate molecule with Imipenem showed an indifference effect both for the E.C 706 clinical lineage and for the ATCC-25922 strain. Thus, the need for further studies with innovative strategies, approaches and technologies is reinforced, in order to elucidate and follow other methodological paths such as pharmacological potential of the 2-oxo-2- phenylethyl benzoate molecule, contributing to the discovery of a new candidate to the drug.