Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFPel - Guaiaca |
Texto Completo: | http://repositorio.ufpel.edu.br/handle/ri/2511 |
Resumo: | External otitis is an inflammation of the outer ear and ear canal, which may or may not be of infectious cause. Negligence will lead to recurrence, hampering treatment and causing bacterial resistance to conventional methodologies. In this context, medicinal plants and plant extracts may be an alternative. Triticum aestivum (wheat) has been shown to act as an antioxidant, anti-inflammatory, pain-killer, as well as used in wound healing. Rosmarinus officinalis L. (rosemary) has antibacterial, anti-inflammatory, pain-killer, anti-mutagenic, diuretic, expectorant, and antioxidant effects. In this context, the objective of this study was to assess the use of wheat and rosemary aqueous extracts, and rosemary essential oil, in the treatment of infectious external otitis. Experimental otitis was induced in rats Wistar with croton oil at 5% in acetone, followed by the introduction of Staphylococcus aureus in the outer ear canal. Animals were separated according to the treatment group: GI 25% wheat aqueous extract in propylene glycol; GII 25% rosemary aqueous extract in propylene glycol; GIII 5% rosemary essential oil in propylene glycol; GIV propylene glycol; and GV saline. The animals were treated for up to seven days, and assessed regarding clinical (according to the Emgard & Hellström method) and hitopathological alterations, on days four, six and ten. Promising results were observed on animals treated with both aqueous extracts, primarily in GI (wheat), but also in GII (rosemary), both were able to reduce clinical and histopathological parameters beyond the effect of the control. This study shows that the aqueous extract of both T. aestivum and R. oficinallis promoted the hastening of the healing process of infectious external otitis. |
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http://lattes.cnpq.br/4437698373980753http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705228J5Nobre, Márcia de OliveiraFontoura, Eduardo Garcia2014-08-20T14:37:54Z2014-07-022014-08-20T14:37:54Z2014-02-14FONTOURA, Eduardo Garcia. Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa. 2014. 51 f. Dissertação (Mestrado em Veterinária) - Universidade Federal de Pelotas, Pelotas, 2014.http://repositorio.ufpel.edu.br/handle/ri/2511External otitis is an inflammation of the outer ear and ear canal, which may or may not be of infectious cause. Negligence will lead to recurrence, hampering treatment and causing bacterial resistance to conventional methodologies. In this context, medicinal plants and plant extracts may be an alternative. Triticum aestivum (wheat) has been shown to act as an antioxidant, anti-inflammatory, pain-killer, as well as used in wound healing. Rosmarinus officinalis L. (rosemary) has antibacterial, anti-inflammatory, pain-killer, anti-mutagenic, diuretic, expectorant, and antioxidant effects. In this context, the objective of this study was to assess the use of wheat and rosemary aqueous extracts, and rosemary essential oil, in the treatment of infectious external otitis. Experimental otitis was induced in rats Wistar with croton oil at 5% in acetone, followed by the introduction of Staphylococcus aureus in the outer ear canal. Animals were separated according to the treatment group: GI 25% wheat aqueous extract in propylene glycol; GII 25% rosemary aqueous extract in propylene glycol; GIII 5% rosemary essential oil in propylene glycol; GIV propylene glycol; and GV saline. The animals were treated for up to seven days, and assessed regarding clinical (according to the Emgard & Hellström method) and hitopathological alterations, on days four, six and ten. Promising results were observed on animals treated with both aqueous extracts, primarily in GI (wheat), but also in GII (rosemary), both were able to reduce clinical and histopathological parameters beyond the effect of the control. This study shows that the aqueous extract of both T. aestivum and R. oficinallis promoted the hastening of the healing process of infectious external otitis.A otite externa é a inflamação do conduto auditivo externo, com etiologia infecciosa ou não. Casos de negligência fazem com que ocorram recidivas, dificultando tratamento e elevando a resistência microbiana aos métodos convencionais, tornando assim as plantas medicinais uma alternativa. O Triticum aestivum (trigo), já demonstrou ação antioxidante, anti-inflamatório, antimicrobiano, hepatoprotetor e cicatrizante. O Rosmarinus officinalis L. (alecrim) possui propriedades medicinais como antimicrobiano, anti-inflamatório, analgésico, antimutagênico, diurético, expectorante e antioxidante. Neste contexto, objetivou-se avaliar a utilização dos extratos aquosos de trigo e alecrim e óleo essencial de alecrim no tratamento da otite externa infecciosa experimental. A otite externa foi induzida em 64 ratos Wistar através da instilação de óleo de cróton 5% em acetona em conjunto com Staphylococcus aureus no conduto auditivo dos animais. Os tratamentos foram divididos em extrato aquoso de trigo 25% em propilenoglicol (GI), extrato aquoso de alecrim 25% em propilenoglicol (GII), óleo essencial de alecrim 5% em propilenoglicol (GIII), propilenoglicol (GIV) e solução fisiológica (GV). Os animais foram tratados por até sete dias e realizadas análises macroscópicas aos quatro, seis e dez dias através do método de Emgård & Hellström para coloração, diâmetro, efusão, além da análise histopatológica, em quatro animais por grupo. Foram observados resultados promissores com o extrato aquoso de trigo (GI), e extrato aquoso de alecrim (GII), sendo capazes de reduzir os parâmetros clínicos macroscópicos, assim como os parâmetros histopatológicos. Nas condições experimentais deste trabalho, a concentração utilizada de óleo essencial não foi efetiva. Assim, demonstrou-se que os extratos aquosos de trigo e alecrim a 25% em propilenoglicol promovem a aceleração da resolução da otite externa infecciosa.application/pdfporUniversidade Federal de PelotasPrograma de Pós-Graduação em VeterináriaUFPelBRVeterináriaFitoterapiaStaphylococcus aureusTrigoAlecrimOtopatiasPhytotherapyStaphylococcus aureusWheatRosemaryEar diseasesCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIARosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosaRosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFPel - Guaiacainstname:Universidade Federal de Pelotas (UFPEL)instacron:UFPELORIGINALdissertacao_eduardo_garcia_fontoura.pdfapplication/pdf1413088http://guaiaca.ufpel.edu.br/xmlui/bitstream/123456789/2511/1/dissertacao_eduardo_garcia_fontoura.pdf273e6ae790ff7b3245afb5b091828f85MD51open accessTEXTdissertacao_eduardo_garcia_fontoura.pdf.txtdissertacao_eduardo_garcia_fontoura.pdf.txtExtracted Texttext/plain104680http://guaiaca.ufpel.edu.br/xmlui/bitstream/123456789/2511/2/dissertacao_eduardo_garcia_fontoura.pdf.txt6c309060eefbd6bc082d80c50208cd30MD52open accessTHUMBNAILdissertacao_eduardo_garcia_fontoura.pdf.jpgdissertacao_eduardo_garcia_fontoura.pdf.jpgGenerated Thumbnailimage/jpeg1375http://guaiaca.ufpel.edu.br/xmlui/bitstream/123456789/2511/3/dissertacao_eduardo_garcia_fontoura.pdf.jpg77d913541a4a7dc4a5090f08d02966a6MD53open access123456789/25112018-07-13 11:55:40.492open accessoai:guaiaca.ufpel.edu.br:123456789/2511Repositório InstitucionalPUBhttp://repositorio.ufpel.edu.br/oai/requestrippel@ufpel.edu.br || repositorio@ufpel.edu.br || aline.batista@ufpel.edu.bropendoar:2018-07-13T14:55:40Repositório Institucional da UFPel - Guaiaca - Universidade Federal de Pelotas (UFPEL)false |
dc.title.por.fl_str_mv |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
dc.title.alternative.eng.fl_str_mv |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
title |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
spellingShingle |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa Fontoura, Eduardo Garcia Fitoterapia Staphylococcus aureus Trigo Alecrim Otopatias Phytotherapy Staphylococcus aureus Wheat Rosemary Ear diseases CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
title_full |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
title_fullStr |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
title_full_unstemmed |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
title_sort |
Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa |
author |
Fontoura, Eduardo Garcia |
author_facet |
Fontoura, Eduardo Garcia |
author_role |
author |
dc.contributor.authorLattes.por.fl_str_mv |
http://lattes.cnpq.br/4437698373980753 |
dc.contributor.advisorLattes.por.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705228J5 |
dc.contributor.advisor1.fl_str_mv |
Nobre, Márcia de Oliveira |
dc.contributor.author.fl_str_mv |
Fontoura, Eduardo Garcia |
contributor_str_mv |
Nobre, Márcia de Oliveira |
dc.subject.por.fl_str_mv |
Fitoterapia Staphylococcus aureus Trigo Alecrim Otopatias |
topic |
Fitoterapia Staphylococcus aureus Trigo Alecrim Otopatias Phytotherapy Staphylococcus aureus Wheat Rosemary Ear diseases CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
Phytotherapy Staphylococcus aureus Wheat Rosemary Ear diseases |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
External otitis is an inflammation of the outer ear and ear canal, which may or may not be of infectious cause. Negligence will lead to recurrence, hampering treatment and causing bacterial resistance to conventional methodologies. In this context, medicinal plants and plant extracts may be an alternative. Triticum aestivum (wheat) has been shown to act as an antioxidant, anti-inflammatory, pain-killer, as well as used in wound healing. Rosmarinus officinalis L. (rosemary) has antibacterial, anti-inflammatory, pain-killer, anti-mutagenic, diuretic, expectorant, and antioxidant effects. In this context, the objective of this study was to assess the use of wheat and rosemary aqueous extracts, and rosemary essential oil, in the treatment of infectious external otitis. Experimental otitis was induced in rats Wistar with croton oil at 5% in acetone, followed by the introduction of Staphylococcus aureus in the outer ear canal. Animals were separated according to the treatment group: GI 25% wheat aqueous extract in propylene glycol; GII 25% rosemary aqueous extract in propylene glycol; GIII 5% rosemary essential oil in propylene glycol; GIV propylene glycol; and GV saline. The animals were treated for up to seven days, and assessed regarding clinical (according to the Emgard & Hellström method) and hitopathological alterations, on days four, six and ten. Promising results were observed on animals treated with both aqueous extracts, primarily in GI (wheat), but also in GII (rosemary), both were able to reduce clinical and histopathological parameters beyond the effect of the control. This study shows that the aqueous extract of both T. aestivum and R. oficinallis promoted the hastening of the healing process of infectious external otitis. |
publishDate |
2014 |
dc.date.accessioned.fl_str_mv |
2014-08-20T14:37:54Z |
dc.date.available.fl_str_mv |
2014-07-02 2014-08-20T14:37:54Z |
dc.date.issued.fl_str_mv |
2014-02-14 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FONTOURA, Eduardo Garcia. Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa. 2014. 51 f. Dissertação (Mestrado em Veterinária) - Universidade Federal de Pelotas, Pelotas, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufpel.edu.br/handle/ri/2511 |
identifier_str_mv |
FONTOURA, Eduardo Garcia. Rosmarinus officinalis L. e Triticum aestivum no tratamento da otite externa infecciosa. 2014. 51 f. Dissertação (Mestrado em Veterinária) - Universidade Federal de Pelotas, Pelotas, 2014. |
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http://repositorio.ufpel.edu.br/handle/ri/2511 |
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por |
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por |
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Universidade Federal de Pelotas |
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Programa de Pós-Graduação em Veterinária |
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UFPel |
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BR |
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Veterinária |
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Universidade Federal de Pelotas |
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