Papilomatose de laringe

Detalhes bibliográficos
Autor(a) principal: von Mülen, Carla
Data de Publicação: 2022
Outros Autores: Rigol, Cristiane, Melchior, Raquel, Argenta, Rodrigo, M. Smith, Mariana, S. Miura, Maurício, Kuhl, Gabriel
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/125224
Resumo: Laryngeal papillomatosis is the most frequent benign neoplasm of the larynx, occurring in children and adults. It is caused by the human papilloma virus, especially types 6 and 11. The clinical course is unpredictable and recurrence is frequent in children. There have been reports of association between this disease and tracheobronchial tree and squamous cell carcinoma of the larynx. Papillomatosis is probably one of thefactors that can predispose a patient to the development of cancer, similarly to alcohol, tobacco, and radiation exposure.Treatment aims at maintaining airway patency and speech. Surgery with carbon dioxide laser is able to achieve this objective, however, without preventing recidivation. The low rates of surgical cure have been stimulating new research with chemotherapics. Unfortunately these have not been successful. Their main purpose is to reduce the extension of the disease and rates of recidivation, slowing down papilloma growth.The present study reviews pathophysiology, the clinical presentation and treatment aspects .
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spelling Papilomatose de laringePapilomatose de laringePapilomatose laríngeapapiloma vírus humano (HPV)laser CO2tratamento adjuvanteLaryngeal papillomatosishuman papilloma virus (HPV)carbon dioxide laseradjuvant treatmentLaryngeal papillomatosis is the most frequent benign neoplasm of the larynx, occurring in children and adults. It is caused by the human papilloma virus, especially types 6 and 11. The clinical course is unpredictable and recurrence is frequent in children. There have been reports of association between this disease and tracheobronchial tree and squamous cell carcinoma of the larynx. Papillomatosis is probably one of thefactors that can predispose a patient to the development of cancer, similarly to alcohol, tobacco, and radiation exposure.Treatment aims at maintaining airway patency and speech. Surgery with carbon dioxide laser is able to achieve this objective, however, without preventing recidivation. The low rates of surgical cure have been stimulating new research with chemotherapics. Unfortunately these have not been successful. Their main purpose is to reduce the extension of the disease and rates of recidivation, slowing down papilloma growth.The present study reviews pathophysiology, the clinical presentation and treatment aspects .A papilomatose de laringe é a neoplasia benigna que mais freqüentemente acomete a laringe, tanto em crianças quanto em adultos. É causada pelo papiloma vírus humano, em especial pelos tipos 6 e 11. A apresentação clínica é variável e a evolução praticamente imprevisível, devido especialmente ao alto grau de recorrência típico desta entidade. Existem diversos relatos que demonstram associação entre estadoença e o carcinoma de células escamosas de laringe e de árvore traqueobrônquica. Acredita-se que a papilomatose seja um dos fatores que predisponham o paciente ao câncer, assim como o são o álcool, o fumo e a exposição à radiação ionizante. O objetivo do tratamento é a manutenção da via aérea e da função vocal. Para tanto, a microcirurgia com laser tem demonstrado os melhores resultados, apesar de nãoimpedir as recorrências. Assim, os pobres índices de cura cirúrgica têm estimulado o desenvolvimento de estudos com quimioterápicos. A proposta do uso destes é reduzir a extensão da doença e a freqüência das recidivas, lentificando o crescimento do papiloma. Essas terapias adjuvantes, entretanto, ainda apresentam pouco sucesso a longo prazo. Realizamos aqui uma revisão da literatura a respeito do assunto, com ênfase nos aspectos de fisiopatologia, apresentação clínica e tratamento.HCPA/FAMED/UFRGS2022-06-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article"A Convite dos Editoresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/125224Clinical & Biomedical Research; Vol. 19 No. 2 (1999): Revista HCPAClinical and Biomedical Research; v. 19 n. 2 (1999): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/125224/85175http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessvon Mülen, Carla Rigol, Cristiane Melchior, Raquel Argenta, Rodrigo M. Smith, Mariana S. Miura, Maurício Kuhl, Gabriel 2022-06-13T13:38:54Zoai:seer.ufrgs.br:article/125224Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-06-13T13:38:54Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Papilomatose de laringe
Papilomatose de laringe
title Papilomatose de laringe
spellingShingle Papilomatose de laringe
von Mülen, Carla
Papilomatose laríngea
papiloma vírus humano (HPV)
laser CO2
tratamento adjuvante
Laryngeal papillomatosis
human papilloma virus (HPV)
carbon dioxide laser
adjuvant treatment
title_short Papilomatose de laringe
title_full Papilomatose de laringe
title_fullStr Papilomatose de laringe
title_full_unstemmed Papilomatose de laringe
title_sort Papilomatose de laringe
author von Mülen, Carla
author_facet von Mülen, Carla
Rigol, Cristiane
Melchior, Raquel
Argenta, Rodrigo
M. Smith, Mariana
S. Miura, Maurício
Kuhl, Gabriel
author_role author
author2 Rigol, Cristiane
Melchior, Raquel
Argenta, Rodrigo
M. Smith, Mariana
S. Miura, Maurício
Kuhl, Gabriel
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv von Mülen, Carla
Rigol, Cristiane
Melchior, Raquel
Argenta, Rodrigo
M. Smith, Mariana
S. Miura, Maurício
Kuhl, Gabriel
dc.subject.por.fl_str_mv Papilomatose laríngea
papiloma vírus humano (HPV)
laser CO2
tratamento adjuvante
Laryngeal papillomatosis
human papilloma virus (HPV)
carbon dioxide laser
adjuvant treatment
topic Papilomatose laríngea
papiloma vírus humano (HPV)
laser CO2
tratamento adjuvante
Laryngeal papillomatosis
human papilloma virus (HPV)
carbon dioxide laser
adjuvant treatment
description Laryngeal papillomatosis is the most frequent benign neoplasm of the larynx, occurring in children and adults. It is caused by the human papilloma virus, especially types 6 and 11. The clinical course is unpredictable and recurrence is frequent in children. There have been reports of association between this disease and tracheobronchial tree and squamous cell carcinoma of the larynx. Papillomatosis is probably one of thefactors that can predispose a patient to the development of cancer, similarly to alcohol, tobacco, and radiation exposure.Treatment aims at maintaining airway patency and speech. Surgery with carbon dioxide laser is able to achieve this objective, however, without preventing recidivation. The low rates of surgical cure have been stimulating new research with chemotherapics. Unfortunately these have not been successful. Their main purpose is to reduce the extension of the disease and rates of recidivation, slowing down papilloma growth.The present study reviews pathophysiology, the clinical presentation and treatment aspects .
publishDate 2022
dc.date.none.fl_str_mv 2022-06-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article"
A Convite dos Editores
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125224
url https://seer.ufrgs.br/index.php/hcpa/article/view/125224
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125224/85175
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 19 No. 2 (1999): Revista HCPA
Clinical and Biomedical Research; v. 19 n. 2 (1999): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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