Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results

Detalhes bibliográficos
Autor(a) principal: F. Dillenburg, Carlos
Data de Publicação: 2022
Outros Autores: Dario P. Kruel, Cleber, D. e Silva, Tiago Luís, Silvio Schier, André, Marafon, Giancarlo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/125711
Resumo: OBJECTIVE: In northern Iran, the high incidence of esophageal cancer was associated to opium. Diethylnitrosamine (DEN) is one of the nitrosamines that presents high risk for experimental cancer of the esophagus. Morphine, the largest alkaloid of opium, has been reported to increase the ethylation of esophageal DNA through DEN and to reduce first-passage hepatic metabolism, when administered in high doses to rats. Our objective was to study the effect of joint administration of morphine and DEN on esophageal carcinogenesis in rats. MATERIAL AND METHODS: For 23 weeks, we studied the effect of joint administration of morphine and DEN on the esophageal carcinogenesis in rats. RESULTS: The animal models that received only DEN presented a higher incidence of tumors than those that received DEN and morphine. CONCLUSION: We concluded that morphine did not influence esophageal carcinogenesis induced by DEN in rats.
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spelling Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary resultsInfluência da morfina na carcinogênese esofágica induzida pela dietilnitrosamina em ratos – resultados preliminarescarcinoma epidermóide do esôfagocarcinogênese esofágicanitrosaminasmorfinaEpidermoid esophageal carcinomaesophageal carcinogenesisnitrosaminesmorphineOBJECTIVE: In northern Iran, the high incidence of esophageal cancer was associated to opium. Diethylnitrosamine (DEN) is one of the nitrosamines that presents high risk for experimental cancer of the esophagus. Morphine, the largest alkaloid of opium, has been reported to increase the ethylation of esophageal DNA through DEN and to reduce first-passage hepatic metabolism, when administered in high doses to rats. Our objective was to study the effect of joint administration of morphine and DEN on esophageal carcinogenesis in rats. MATERIAL AND METHODS: For 23 weeks, we studied the effect of joint administration of morphine and DEN on the esophageal carcinogenesis in rats. RESULTS: The animal models that received only DEN presented a higher incidence of tumors than those that received DEN and morphine. CONCLUSION: We concluded that morphine did not influence esophageal carcinogenesis induced by DEN in rats.OBJETIVOS: A alta incidência de câncer esofagiano no norte do Irã foi associada ao ópio. A dietilnitrosamina (DEN) é uma das nitrosaminas com maior potencial de produzir câncer experimental no esôfago. Morfina, o maior alcalóide do ópio, quando administrada em altas doses a ratos, aumentou a etilação do DNA esofágico pela DEN e reduziu seu metabolismo hepático de primeira passagem. O presente trabalho objetivou estudaro efeito da administração conjunta de morfina e DEN na carcinogênese esofágica. MATERIAIS E MÉTODOS: Durante 23 semanas, estudamos o efeito da administração conjunta de morfina e DEN na carcinogênese esofágica em ratos. RESULTADOS: Encontrou-se maior incidência tumoral nos animais que receberam somente DEN em relação aos que receberam DEN e morfina. CONCLUSÃO: Concluiu-se que a morfina não apresentou influência sobre a carcinogênese esofágica induzida pela DEN em ratos.HCPA/FAMED/UFRGS2022-07-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/125711Clinical & Biomedical Research; Vol. 21 No. 1 (2001): Revista HCPAClinical and Biomedical Research; v. 21 n. 1 (2001): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/125711/85367http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessF. Dillenburg, Carlos Dario P. Kruel, Cleber D. e Silva, Tiago Luís Silvio Schier, André Marafon, Giancarlo 2022-07-07T12:08:12Zoai:seer.ufrgs.br:article/125711Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2022-07-07T12:08:12Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
Influência da morfina na carcinogênese esofágica induzida pela dietilnitrosamina em ratos – resultados preliminares
title Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
spellingShingle Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
F. Dillenburg, Carlos
carcinoma epidermóide do esôfago
carcinogênese esofágica
nitrosaminas
morfina
Epidermoid esophageal carcinoma
esophageal carcinogenesis
nitrosamines
morphine
title_short Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
title_full Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
title_fullStr Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
title_full_unstemmed Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
title_sort Morphine influence on esophageal carcinogenesis induced by diethylnitrosamine in rats - preliminary results
author F. Dillenburg, Carlos
author_facet F. Dillenburg, Carlos
Dario P. Kruel, Cleber
D. e Silva, Tiago Luís
Silvio Schier, André
Marafon, Giancarlo
author_role author
author2 Dario P. Kruel, Cleber
D. e Silva, Tiago Luís
Silvio Schier, André
Marafon, Giancarlo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv F. Dillenburg, Carlos
Dario P. Kruel, Cleber
D. e Silva, Tiago Luís
Silvio Schier, André
Marafon, Giancarlo
dc.subject.por.fl_str_mv carcinoma epidermóide do esôfago
carcinogênese esofágica
nitrosaminas
morfina
Epidermoid esophageal carcinoma
esophageal carcinogenesis
nitrosamines
morphine
topic carcinoma epidermóide do esôfago
carcinogênese esofágica
nitrosaminas
morfina
Epidermoid esophageal carcinoma
esophageal carcinogenesis
nitrosamines
morphine
description OBJECTIVE: In northern Iran, the high incidence of esophageal cancer was associated to opium. Diethylnitrosamine (DEN) is one of the nitrosamines that presents high risk for experimental cancer of the esophagus. Morphine, the largest alkaloid of opium, has been reported to increase the ethylation of esophageal DNA through DEN and to reduce first-passage hepatic metabolism, when administered in high doses to rats. Our objective was to study the effect of joint administration of morphine and DEN on esophageal carcinogenesis in rats. MATERIAL AND METHODS: For 23 weeks, we studied the effect of joint administration of morphine and DEN on the esophageal carcinogenesis in rats. RESULTS: The animal models that received only DEN presented a higher incidence of tumors than those that received DEN and morphine. CONCLUSION: We concluded that morphine did not influence esophageal carcinogenesis induced by DEN in rats.
publishDate 2022
dc.date.none.fl_str_mv 2022-07-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125711
url https://seer.ufrgs.br/index.php/hcpa/article/view/125711
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/125711/85367
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 21 No. 1 (2001): Revista HCPA
Clinical and Biomedical Research; v. 21 n. 1 (2001): Revista HCPA
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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