Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/7242 |
Resumo: | Background: The evaluation of renal function should be performed with glomerular filtration rate (GFR) estimation employing the Modification of Diet in Renal Disease (MDRD) study equation, which includes age, gender, ethnicity and serum creatinine. However, creatinine methods require traceability with standardized methods. Objective: To analyse the impact of creatinine calibration on MDRD calculated GFR. Methods: 140 samples of plasma with creatinine values <2,0 mg/dl were analysed by Jaffé’s reaction with Creatinina Modular P (Roche ®; method A; reference) and Creatinina Advia 1650 (Bayer ®; method B; non-standardized). The results with the different methods were compared and aligned with standardized method through a conversion formula. MDRD GFR was estimated. Results: Values were higher for method B (1.03 ± 0.29 vs. 0.86 ± 0.32 mg/dl, P<0.001). This difference declined when methods were aligned with the equation y=1.07x -0.249, and the aligned values were 0,9 ± 0,31 mg/dl. Non-traceable creatinine methods misclassificaed chronic kidney disease in 10% more (false positive). This disagreement disappeared after the regression alignment. Conclusion: Creatinine method calibration has a large impact over the final results of serum creatinine and GFR. The alignment of the non-standardized results through conversion formulas is a reasonable alternative to harmonize serum creatinine results while waiting for the full implementation of international standardization programs. |
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Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equationEfeito da Calibração da Creatinina Sobre a Estimativa da Taxa de Filtração Glomerular pela Equação MDRDTaxa de filtração glomerularTFGcreatinina séricaModification of Diet in Renal DiseaseMDRDEndocrinologia Background: The evaluation of renal function should be performed with glomerular filtration rate (GFR) estimation employing the Modification of Diet in Renal Disease (MDRD) study equation, which includes age, gender, ethnicity and serum creatinine. However, creatinine methods require traceability with standardized methods. Objective: To analyse the impact of creatinine calibration on MDRD calculated GFR. Methods: 140 samples of plasma with creatinine values <2,0 mg/dl were analysed by Jaffé’s reaction with Creatinina Modular P (Roche ®; method A; reference) and Creatinina Advia 1650 (Bayer ®; method B; non-standardized). The results with the different methods were compared and aligned with standardized method through a conversion formula. MDRD GFR was estimated. Results: Values were higher for method B (1.03 ± 0.29 vs. 0.86 ± 0.32 mg/dl, P<0.001). This difference declined when methods were aligned with the equation y=1.07x -0.249, and the aligned values were 0,9 ± 0,31 mg/dl. Non-traceable creatinine methods misclassificaed chronic kidney disease in 10% more (false positive). This disagreement disappeared after the regression alignment. Conclusion: Creatinine method calibration has a large impact over the final results of serum creatinine and GFR. The alignment of the non-standardized results through conversion formulas is a reasonable alternative to harmonize serum creatinine results while waiting for the full implementation of international standardization programs. Introdução: A avaliação da função renal deve ser realizada através da estimativa da taxa de filtração glomerular (TFG) com a equação do estudo Modification of Diet in Renal Disease (MDRD), a qual inclui a idade, gênero, etnia e creatinina. No entanto, a medida da creatinina requer rastreabilidade com método padrão (equiparação) para sua calibração. Objetivo: Verificar o impacto da calibração da creatinina na TFG calculada pela fórmula do MDRD. Métodos: Foram analisadas 140 amostras de soro com creatinina <2,0 mg/dl pela reação de Jaffé com Creatinina Modular P (Roche ®; método A; calibrado) e pela Creatinina Advia 1650 (Bayer ®; método B; não calibrado). Os resultados obtidos foram comparados entre si e alinhados por fórmula de conversão. A TFG foi estimada através da fórmula do MDRD. Resultados: O método B teve resultados mais altos que o método A (1,03 ± 0,29 vs. 0,86 ± 0,32 mg/dl, P<0,001). Esta diferença diminuiu quando os resultados do método B foram alinhados ao método A através da equação y=1,07x -0,249, sendo os valores do método alinhado por regressão de 0,9 ± 0,31 mg/dl. O método não calibrado identificou 10% mais de casos de doença renal renal crônica (falso positivos). Essa discordância desaparece após o alinhamento. Conclusão: A calibração dos métodos de creatinina tem um impacto importante nos resultados finais de creatinina e TFG. O alinhamento de resultados não padronizados através de fórmulas de conversão pode ser uma alternativa para harmonizar os resultados de creatinina sérica enquanto programas internacionais de padronização não estiverem ainda totalmente implantados.HCPA/FAMED/UFRGS2009-01-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/7242Clinical & Biomedical Research; Vol. 28 No. 3 (2008): Revista HCPAClinical and Biomedical Research; v. 28 n. 3 (2008): Revista HCPA2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/7242/4589Spessatto, DéboraSilveiro, Sandra PinhoCamargo, Joíza Linsinfo:eu-repo/semantics/openAccess2020-01-16T16:17:58Zoai:seer.ufrgs.br:article/7242Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2020-01-16T16:17:58Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation Efeito da Calibração da Creatinina Sobre a Estimativa da Taxa de Filtração Glomerular pela Equação MDRD |
title |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation |
spellingShingle |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation Spessatto, Débora Taxa de filtração glomerular TFG creatinina sérica Modification of Diet in Renal Disease MDRD Endocrinologia |
title_short |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation |
title_full |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation |
title_fullStr |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation |
title_full_unstemmed |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation |
title_sort |
Effect of creatinine assay calibration on glomerular filtration rate prediction by MDRD equation |
author |
Spessatto, Débora |
author_facet |
Spessatto, Débora Silveiro, Sandra Pinho Camargo, Joíza Lins |
author_role |
author |
author2 |
Silveiro, Sandra Pinho Camargo, Joíza Lins |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Spessatto, Débora Silveiro, Sandra Pinho Camargo, Joíza Lins |
dc.subject.por.fl_str_mv |
Taxa de filtração glomerular TFG creatinina sérica Modification of Diet in Renal Disease MDRD Endocrinologia |
topic |
Taxa de filtração glomerular TFG creatinina sérica Modification of Diet in Renal Disease MDRD Endocrinologia |
description |
Background: The evaluation of renal function should be performed with glomerular filtration rate (GFR) estimation employing the Modification of Diet in Renal Disease (MDRD) study equation, which includes age, gender, ethnicity and serum creatinine. However, creatinine methods require traceability with standardized methods. Objective: To analyse the impact of creatinine calibration on MDRD calculated GFR. Methods: 140 samples of plasma with creatinine values <2,0 mg/dl were analysed by Jaffé’s reaction with Creatinina Modular P (Roche ®; method A; reference) and Creatinina Advia 1650 (Bayer ®; method B; non-standardized). The results with the different methods were compared and aligned with standardized method through a conversion formula. MDRD GFR was estimated. Results: Values were higher for method B (1.03 ± 0.29 vs. 0.86 ± 0.32 mg/dl, P<0.001). This difference declined when methods were aligned with the equation y=1.07x -0.249, and the aligned values were 0,9 ± 0,31 mg/dl. Non-traceable creatinine methods misclassificaed chronic kidney disease in 10% more (false positive). This disagreement disappeared after the regression alignment. Conclusion: Creatinine method calibration has a large impact over the final results of serum creatinine and GFR. The alignment of the non-standardized results through conversion formulas is a reasonable alternative to harmonize serum creatinine results while waiting for the full implementation of international standardization programs. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/7242 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/7242 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/7242/4589 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 28 No. 3 (2008): Revista HCPA Clinical and Biomedical Research; v. 28 n. 3 (2008): Revista HCPA 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
_version_ |
1799767051327242240 |