Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/18619 |
Resumo: | Background: Chronic kidney disease (CKD) is a significant public health problem. It is still controversial if the metabolic syndrome (MS) is associated with CKD.Methods: Cross-sectional study of individuals at high risk of developing diabetes at the endocrine outpatient clinic of Hospital de Clínicas de Porto Alegre. Fasting and 2h-plasma glucose levels, A1c, insulin, cholesterol, triglycerides, creatinine, and urinary albumin excretion were measured. MS was defined as the presence of three out of five of the following factors: hypertension, low HDL-cholesterol, high triglyceride levels, elevated plasma glucose, and high waist circumference. Glomerular filtration rate (GFR) was estimated by the Modified Diet in Renal Disease (MDRD) equation and insulin resistance was measure using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Correlation analyses were performed between each MS components and the GFR.Results: CKD was present in 20.9% of the subjects. GFR was lower in subjects with MS compared with those without MS (p = 0.019). Estimated GFR decreased with the increasing number of MS criteria (mean ± SD; zero or one criterion 103.09 ± 9.5 vs. two criteria 99.14 ± 21.2 vs. three criteria 90.9 ± 21.1 vs. four criteria 91.0 ± 19.4 vs. five criteria 80.9 ± 23.5 mL/min per 1.73m2; p = 0.053). Only systolic arterial blood pressure was related to eGFR (r = 0.280; p = 0.003).Discussion: According to our data, the previously described association between MS and decreased renal function was confirmed, mostly determined by the hypertension criterion.Conclusion: These data suggest that the relationship between MS and CKD is driven mostly by abnormalities in blood pressure homeostasis. |
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Clinical and Biomedical Research |
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Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose ToleranceDiabetesMetabolyc SyndromeChronic Kidney Disease.DiabetesBackground: Chronic kidney disease (CKD) is a significant public health problem. It is still controversial if the metabolic syndrome (MS) is associated with CKD.Methods: Cross-sectional study of individuals at high risk of developing diabetes at the endocrine outpatient clinic of Hospital de Clínicas de Porto Alegre. Fasting and 2h-plasma glucose levels, A1c, insulin, cholesterol, triglycerides, creatinine, and urinary albumin excretion were measured. MS was defined as the presence of three out of five of the following factors: hypertension, low HDL-cholesterol, high triglyceride levels, elevated plasma glucose, and high waist circumference. Glomerular filtration rate (GFR) was estimated by the Modified Diet in Renal Disease (MDRD) equation and insulin resistance was measure using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Correlation analyses were performed between each MS components and the GFR.Results: CKD was present in 20.9% of the subjects. GFR was lower in subjects with MS compared with those without MS (p = 0.019). Estimated GFR decreased with the increasing number of MS criteria (mean ± SD; zero or one criterion 103.09 ± 9.5 vs. two criteria 99.14 ± 21.2 vs. three criteria 90.9 ± 21.1 vs. four criteria 91.0 ± 19.4 vs. five criteria 80.9 ± 23.5 mL/min per 1.73m2; p = 0.053). Only systolic arterial blood pressure was related to eGFR (r = 0.280; p = 0.003).Discussion: According to our data, the previously described association between MS and decreased renal function was confirmed, mostly determined by the hypertension criterion.Conclusion: These data suggest that the relationship between MS and CKD is driven mostly by abnormalities in blood pressure homeostasis.HCPA/FAMED/UFRGS2011-04-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/18619Clinical & Biomedical Research; Vol. 30 No. 4 (2010): Especial Diabetes Melito: Revista HCPAClinical and Biomedical Research; v. 30 n. 4 (2010): Especial Diabetes Melito2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/18619/11646Smith, Alessandra LocatelliBorges Fortes, Barbara GastalAmérico, André DiasPiccoli, VanessaGarcia, Sheila PiccoliJaeger, BrunnaZampieri, JulianaRocha, EnnioXavier, AliceGhisleni, GabrieleCanani, Luis HenriqueGerchman, Fernandoinfo:eu-repo/semantics/openAccess2020-01-16T17:42:03Zoai:seer.ufrgs.br:article/18619Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2020-01-16T17:42:03Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
title |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
spellingShingle |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance Smith, Alessandra Locatelli Diabetes Metabolyc Syndrome Chronic Kidney Disease. Diabetes |
title_short |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
title_full |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
title_fullStr |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
title_full_unstemmed |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
title_sort |
Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance |
author |
Smith, Alessandra Locatelli |
author_facet |
Smith, Alessandra Locatelli Borges Fortes, Barbara Gastal Américo, André Dias Piccoli, Vanessa Garcia, Sheila Piccoli Jaeger, Brunna Zampieri, Juliana Rocha, Ennio Xavier, Alice Ghisleni, Gabriele Canani, Luis Henrique Gerchman, Fernando |
author_role |
author |
author2 |
Borges Fortes, Barbara Gastal Américo, André Dias Piccoli, Vanessa Garcia, Sheila Piccoli Jaeger, Brunna Zampieri, Juliana Rocha, Ennio Xavier, Alice Ghisleni, Gabriele Canani, Luis Henrique Gerchman, Fernando |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Smith, Alessandra Locatelli Borges Fortes, Barbara Gastal Américo, André Dias Piccoli, Vanessa Garcia, Sheila Piccoli Jaeger, Brunna Zampieri, Juliana Rocha, Ennio Xavier, Alice Ghisleni, Gabriele Canani, Luis Henrique Gerchman, Fernando |
dc.subject.por.fl_str_mv |
Diabetes Metabolyc Syndrome Chronic Kidney Disease. Diabetes |
topic |
Diabetes Metabolyc Syndrome Chronic Kidney Disease. Diabetes |
description |
Background: Chronic kidney disease (CKD) is a significant public health problem. It is still controversial if the metabolic syndrome (MS) is associated with CKD.Methods: Cross-sectional study of individuals at high risk of developing diabetes at the endocrine outpatient clinic of Hospital de Clínicas de Porto Alegre. Fasting and 2h-plasma glucose levels, A1c, insulin, cholesterol, triglycerides, creatinine, and urinary albumin excretion were measured. MS was defined as the presence of three out of five of the following factors: hypertension, low HDL-cholesterol, high triglyceride levels, elevated plasma glucose, and high waist circumference. Glomerular filtration rate (GFR) was estimated by the Modified Diet in Renal Disease (MDRD) equation and insulin resistance was measure using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Correlation analyses were performed between each MS components and the GFR.Results: CKD was present in 20.9% of the subjects. GFR was lower in subjects with MS compared with those without MS (p = 0.019). Estimated GFR decreased with the increasing number of MS criteria (mean ± SD; zero or one criterion 103.09 ± 9.5 vs. two criteria 99.14 ± 21.2 vs. three criteria 90.9 ± 21.1 vs. four criteria 91.0 ± 19.4 vs. five criteria 80.9 ± 23.5 mL/min per 1.73m2; p = 0.053). Only systolic arterial blood pressure was related to eGFR (r = 0.280; p = 0.003).Discussion: According to our data, the previously described association between MS and decreased renal function was confirmed, mostly determined by the hypertension criterion.Conclusion: These data suggest that the relationship between MS and CKD is driven mostly by abnormalities in blood pressure homeostasis. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/18619 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/18619 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/18619/11646 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 30 No. 4 (2010): Especial Diabetes Melito: Revista HCPA Clinical and Biomedical Research; v. 30 n. 4 (2010): Especial Diabetes Melito 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
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1799767052287737856 |