Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance

Detalhes bibliográficos
Autor(a) principal: Smith, Alessandra Locatelli
Data de Publicação: 2011
Outros Autores: Borges Fortes, Barbara Gastal, Américo, André Dias, Piccoli, Vanessa, Garcia, Sheila Piccoli, Jaeger, Brunna, Zampieri, Juliana, Rocha, Ennio, Xavier, Alice, Ghisleni, Gabriele, Canani, Luis Henrique, Gerchman, Fernando
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/18619
Resumo: Background: Chronic kidney disease (CKD) is a significant public health problem. It is still controversial if the metabolic syndrome (MS) is associated with CKD.Methods: Cross-sectional study of individuals at high risk of developing diabetes at the endocrine outpatient clinic of Hospital de Clínicas de Porto Alegre. Fasting and 2h-plasma glucose levels, A1c, insulin, cholesterol, triglycerides, creatinine, and urinary albumin excretion were measured. MS was defined as the presence of three out of five of the following factors: hypertension, low HDL-cholesterol, high triglyceride levels, elevated plasma glucose, and high waist circumference. Glomerular filtration rate (GFR) was estimated by the Modified Diet in Renal Disease (MDRD) equation and insulin resistance was measure using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Correlation analyses were performed between each MS components and the GFR.Results: CKD was present in 20.9% of the subjects. GFR was lower in subjects with MS compared with those without MS (p = 0.019). Estimated GFR decreased with the increasing number of MS criteria (mean ± SD; zero or one criterion 103.09 ± 9.5 vs. two criteria 99.14 ± 21.2 vs. three criteria 90.9 ± 21.1 vs. four criteria 91.0 ± 19.4 vs. five criteria 80.9 ± 23.5 mL/min per 1.73m2; p = 0.053). Only systolic arterial blood pressure was related to eGFR (r = 0.280; p = 0.003).Discussion: According to our data, the previously described association between MS and decreased renal function was confirmed, mostly determined by the hypertension criterion.Conclusion: These data suggest that the relationship between MS and CKD is driven mostly by abnormalities in blood pressure homeostasis.
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spelling Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose ToleranceDiabetesMetabolyc SyndromeChronic Kidney Disease.DiabetesBackground: Chronic kidney disease (CKD) is a significant public health problem. It is still controversial if the metabolic syndrome (MS) is associated with CKD.Methods: Cross-sectional study of individuals at high risk of developing diabetes at the endocrine outpatient clinic of Hospital de Clínicas de Porto Alegre. Fasting and 2h-plasma glucose levels, A1c, insulin, cholesterol, triglycerides, creatinine, and urinary albumin excretion were measured. MS was defined as the presence of three out of five of the following factors: hypertension, low HDL-cholesterol, high triglyceride levels, elevated plasma glucose, and high waist circumference. Glomerular filtration rate (GFR) was estimated by the Modified Diet in Renal Disease (MDRD) equation and insulin resistance was measure using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Correlation analyses were performed between each MS components and the GFR.Results: CKD was present in 20.9% of the subjects. GFR was lower in subjects with MS compared with those without MS (p = 0.019). Estimated GFR decreased with the increasing number of MS criteria (mean ± SD; zero or one criterion 103.09 ± 9.5 vs. two criteria 99.14 ± 21.2 vs. three criteria 90.9 ± 21.1 vs. four criteria 91.0 ± 19.4 vs. five criteria 80.9 ± 23.5 mL/min per 1.73m2; p = 0.053). Only systolic arterial blood pressure was related to eGFR (r = 0.280; p = 0.003).Discussion: According to our data, the previously described association between MS and decreased renal function was confirmed, mostly determined by the hypertension criterion.Conclusion: These data suggest that the relationship between MS and CKD is driven mostly by abnormalities in blood pressure homeostasis.HCPA/FAMED/UFRGS2011-04-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/18619Clinical & Biomedical Research; Vol. 30 No. 4 (2010): Especial Diabetes Melito: Revista HCPAClinical and Biomedical Research; v. 30 n. 4 (2010): Especial Diabetes Melito2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/18619/11646Smith, Alessandra LocatelliBorges Fortes, Barbara GastalAmérico, André DiasPiccoli, VanessaGarcia, Sheila PiccoliJaeger, BrunnaZampieri, JulianaRocha, EnnioXavier, AliceGhisleni, GabrieleCanani, Luis HenriqueGerchman, Fernandoinfo:eu-repo/semantics/openAccess2020-01-16T17:42:03Zoai:seer.ufrgs.br:article/18619Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2020-01-16T17:42:03Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
title Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
spellingShingle Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
Smith, Alessandra Locatelli
Diabetes
Metabolyc Syndrome
Chronic Kidney Disease.
Diabetes
title_short Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
title_full Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
title_fullStr Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
title_full_unstemmed Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
title_sort Hypertension is the Main Determinant Behind the Association Between Metabolic Syndrome and Chronic kidney Disease in Subjects with Different Degrees of Glucose Tolerance
author Smith, Alessandra Locatelli
author_facet Smith, Alessandra Locatelli
Borges Fortes, Barbara Gastal
Américo, André Dias
Piccoli, Vanessa
Garcia, Sheila Piccoli
Jaeger, Brunna
Zampieri, Juliana
Rocha, Ennio
Xavier, Alice
Ghisleni, Gabriele
Canani, Luis Henrique
Gerchman, Fernando
author_role author
author2 Borges Fortes, Barbara Gastal
Américo, André Dias
Piccoli, Vanessa
Garcia, Sheila Piccoli
Jaeger, Brunna
Zampieri, Juliana
Rocha, Ennio
Xavier, Alice
Ghisleni, Gabriele
Canani, Luis Henrique
Gerchman, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Smith, Alessandra Locatelli
Borges Fortes, Barbara Gastal
Américo, André Dias
Piccoli, Vanessa
Garcia, Sheila Piccoli
Jaeger, Brunna
Zampieri, Juliana
Rocha, Ennio
Xavier, Alice
Ghisleni, Gabriele
Canani, Luis Henrique
Gerchman, Fernando
dc.subject.por.fl_str_mv Diabetes
Metabolyc Syndrome
Chronic Kidney Disease.
Diabetes
topic Diabetes
Metabolyc Syndrome
Chronic Kidney Disease.
Diabetes
description Background: Chronic kidney disease (CKD) is a significant public health problem. It is still controversial if the metabolic syndrome (MS) is associated with CKD.Methods: Cross-sectional study of individuals at high risk of developing diabetes at the endocrine outpatient clinic of Hospital de Clínicas de Porto Alegre. Fasting and 2h-plasma glucose levels, A1c, insulin, cholesterol, triglycerides, creatinine, and urinary albumin excretion were measured. MS was defined as the presence of three out of five of the following factors: hypertension, low HDL-cholesterol, high triglyceride levels, elevated plasma glucose, and high waist circumference. Glomerular filtration rate (GFR) was estimated by the Modified Diet in Renal Disease (MDRD) equation and insulin resistance was measure using the Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR). Correlation analyses were performed between each MS components and the GFR.Results: CKD was present in 20.9% of the subjects. GFR was lower in subjects with MS compared with those without MS (p = 0.019). Estimated GFR decreased with the increasing number of MS criteria (mean ± SD; zero or one criterion 103.09 ± 9.5 vs. two criteria 99.14 ± 21.2 vs. three criteria 90.9 ± 21.1 vs. four criteria 91.0 ± 19.4 vs. five criteria 80.9 ± 23.5 mL/min per 1.73m2; p = 0.053). Only systolic arterial blood pressure was related to eGFR (r = 0.280; p = 0.003).Discussion: According to our data, the previously described association between MS and decreased renal function was confirmed, mostly determined by the hypertension criterion.Conclusion: These data suggest that the relationship between MS and CKD is driven mostly by abnormalities in blood pressure homeostasis.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/18619
url https://seer.ufrgs.br/index.php/hcpa/article/view/18619
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/18619/11646
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 30 No. 4 (2010): Especial Diabetes Melito: Revista HCPA
Clinical and Biomedical Research; v. 30 n. 4 (2010): Especial Diabetes Melito
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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