TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study

Detalhes bibliográficos
Autor(a) principal: Weissheimer, Camila
Data de Publicação: 2019
Outros Autores: Wagner, Vivian Petersen, Webber, Liana Preto, Sant’Ana Filho, Manoel, dos Santos, Jean Nunes, Martins, Manoela, Meurer, Luise, Martins, Marco Antônio Trevizani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/83687
Resumo: Introduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity and patients’ prognosis.Methods: Sixty-eight patients with histopathological diagnosis of OSCC were included, as 9 cases of normal oral mucosa for comparison purposes. OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 was performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively.Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival.Conclusion: TGF-β1 had no prognostic value and appears to maintain it’s suppressive role concerning cell proliferation. Keywords: Head and neck neoplasms; prognosis; transforming growth factors 
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spelling TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical studyHead and neck neoplasmsprognosistransforming growth factorsIntroduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity and patients’ prognosis.Methods: Sixty-eight patients with histopathological diagnosis of OSCC were included, as 9 cases of normal oral mucosa for comparison purposes. OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 was performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively.Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival.Conclusion: TGF-β1 had no prognostic value and appears to maintain it’s suppressive role concerning cell proliferation. Keywords: Head and neck neoplasms; prognosis; transforming growth factors HCPA/FAMED/UFRGS2019-02-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/83687Clinical & Biomedical Research; Vol. 38 No. 4 (2018): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 38 n. 4 (2018): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/83687/pdfCopyright (c) 2019 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessWeissheimer, CamilaWagner, Vivian PetersenWebber, Liana PretoSant’Ana Filho, Manoeldos Santos, Jean NunesMartins, ManoelaMeurer, LuiseMartins, Marco Antônio Trevizani2024-01-19T14:22:37Zoai:seer.ufrgs.br:article/83687Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:22:37Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
title TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
spellingShingle TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
Weissheimer, Camila
Head and neck neoplasms
prognosis
transforming growth factors
title_short TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
title_full TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
title_fullStr TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
title_full_unstemmed TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
title_sort TGF-β1 and its association with clinicopathological features, proliferative activity and prognosis in oral squamous cell carcinoma: An immunohistochemical study
author Weissheimer, Camila
author_facet Weissheimer, Camila
Wagner, Vivian Petersen
Webber, Liana Preto
Sant’Ana Filho, Manoel
dos Santos, Jean Nunes
Martins, Manoela
Meurer, Luise
Martins, Marco Antônio Trevizani
author_role author
author2 Wagner, Vivian Petersen
Webber, Liana Preto
Sant’Ana Filho, Manoel
dos Santos, Jean Nunes
Martins, Manoela
Meurer, Luise
Martins, Marco Antônio Trevizani
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Weissheimer, Camila
Wagner, Vivian Petersen
Webber, Liana Preto
Sant’Ana Filho, Manoel
dos Santos, Jean Nunes
Martins, Manoela
Meurer, Luise
Martins, Marco Antônio Trevizani
dc.subject.por.fl_str_mv Head and neck neoplasms
prognosis
transforming growth factors
topic Head and neck neoplasms
prognosis
transforming growth factors
description Introduction: The prognostic value of transforming growth factor beta-1 (TGF-ß1) in oral cancer remains unclear. Therefore, the aim of this study was to evaluate TGF-β1 expression in oral squamous cell carcinoma (OSCC) samples and its association with clinicopathological data, tumor proliferative activity and patients’ prognosis.Methods: Sixty-eight patients with histopathological diagnosis of OSCC were included, as 9 cases of normal oral mucosa for comparison purposes. OSCC sample was categorized according to patients’ outcomes in favorable prognosis (n=30) or unfavorable prognosis (n=38). Immunohistochemical staining for TGF-β1 and Ki-67 was performed. The slides were semi-quantitatively and quantitatively evaluated for TGF-β1 and Ki-67, respectively.Results: TGF-β1 was significantly increased in OSCC compared to normal oral mucosa (<0.01). An inverse correlation was found between TGF-β1 and Ki67 staining in OSCC (p=0.01). No association was found between TGF-β1 expression and OSCC clinicopathological features, prognosis or survival.Conclusion: TGF-β1 had no prognostic value and appears to maintain it’s suppressive role concerning cell proliferation. Keywords: Head and neck neoplasms; prognosis; transforming growth factors 
publishDate 2019
dc.date.none.fl_str_mv 2019-02-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/83687
url https://seer.ufrgs.br/index.php/hcpa/article/view/83687
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/83687/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2019 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 38 No. 4 (2018): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 38 n. 4 (2018): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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