Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters

Detalhes bibliográficos
Autor(a) principal: Ottobelli Chielle, Eduardo
Data de Publicação: 2018
Outros Autores: Muller Ogliari, Vanieli Cristina, de Carvalho, Diego, Pertile Remor, Aline
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/79449
Resumo: Introduction: Obesity is associated with the development of metabolic disorders that can be diagnosed through inflammatory and oxidative biomarkers.Background: This study evaluated the influence of obesity and overweight on serum concentrations of vitamins C and E, transforming growth factor beta 1 (TGF-β1) and cardiometabolic parameters.Methods: A cross-sectional study was conducted with 169 participants (24 normal weight, 16 overweight and 129 obese). Anthropometric measures and concentrations of vitamins C and E, thiobarbituric acid reactive substances (TBARS), TGF-β1, lipid profile, glycated hemoglobin (HbA1c), glucose and insulin were determined, and homeostatic model assessment of insulin resistance (HOMA-IR) and insulin sensitivity (IS) were calculated.Results: Obese and overweight participants showed significantly higher levels of TGF-β1, vitamin E, insulin, HbA1c, glucose, cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides, HOMA-IR, and TBARS compared with normal weight patients, associated with a significant reduction in IS, high-density lipoprotein cholesterol (HDL-c), and vitamin C.Conclusion: Obesity and overweight may lead to significant changes in TGF-B1, biochemical and oxidative markers. Increased levels of TGF-β1 may promote inflammation and interfere with IS. Reduced concentrations of vitamin C and increased levels of TBARS led to a redox imbalance in obese and overweight patients, suggesting that vitamin E is not a promising oxidative biomarker since it is lipophilic and its concentration is influenced by body fat. These results may help determine the oxidative and inflammatory pathways related to obesity and its comorbidities.Keywords: Obesity; vitamins; antioxidants; metabolism
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spelling Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parametersObesityvitaminsantioxidantsmetabolismIntroduction: Obesity is associated with the development of metabolic disorders that can be diagnosed through inflammatory and oxidative biomarkers.Background: This study evaluated the influence of obesity and overweight on serum concentrations of vitamins C and E, transforming growth factor beta 1 (TGF-β1) and cardiometabolic parameters.Methods: A cross-sectional study was conducted with 169 participants (24 normal weight, 16 overweight and 129 obese). Anthropometric measures and concentrations of vitamins C and E, thiobarbituric acid reactive substances (TBARS), TGF-β1, lipid profile, glycated hemoglobin (HbA1c), glucose and insulin were determined, and homeostatic model assessment of insulin resistance (HOMA-IR) and insulin sensitivity (IS) were calculated.Results: Obese and overweight participants showed significantly higher levels of TGF-β1, vitamin E, insulin, HbA1c, glucose, cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides, HOMA-IR, and TBARS compared with normal weight patients, associated with a significant reduction in IS, high-density lipoprotein cholesterol (HDL-c), and vitamin C.Conclusion: Obesity and overweight may lead to significant changes in TGF-B1, biochemical and oxidative markers. Increased levels of TGF-β1 may promote inflammation and interfere with IS. Reduced concentrations of vitamin C and increased levels of TBARS led to a redox imbalance in obese and overweight patients, suggesting that vitamin E is not a promising oxidative biomarker since it is lipophilic and its concentration is influenced by body fat. These results may help determine the oxidative and inflammatory pathways related to obesity and its comorbidities.Keywords: Obesity; vitamins; antioxidants; metabolismHCPA/FAMED/UFRGS2018-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/79449Clinical & Biomedical Research; Vol. 38 No. 3 (2018): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 38 n. 3 (2018): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/79449/pdfCopyright (c) 2018 Eduardo Ottobelli Chielle, Vanieli Cristina Muller Ogliari, Diego de Carvalho, Aline Pertile Remorinfo:eu-repo/semantics/openAccessOttobelli Chielle, EduardoMuller Ogliari, Vanieli Cristinade Carvalho, DiegoPertile Remor, Aline2024-01-19T14:22:48Zoai:seer.ufrgs.br:article/79449Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:22:48Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
title Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
spellingShingle Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
Ottobelli Chielle, Eduardo
Obesity
vitamins
antioxidants
metabolism
title_short Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
title_full Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
title_fullStr Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
title_full_unstemmed Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
title_sort Influence of obesity and overweight on transforming growth factor beta 1 levels and other oxidative and cardiometabolic parameters
author Ottobelli Chielle, Eduardo
author_facet Ottobelli Chielle, Eduardo
Muller Ogliari, Vanieli Cristina
de Carvalho, Diego
Pertile Remor, Aline
author_role author
author2 Muller Ogliari, Vanieli Cristina
de Carvalho, Diego
Pertile Remor, Aline
author2_role author
author
author
dc.contributor.author.fl_str_mv Ottobelli Chielle, Eduardo
Muller Ogliari, Vanieli Cristina
de Carvalho, Diego
Pertile Remor, Aline
dc.subject.por.fl_str_mv Obesity
vitamins
antioxidants
metabolism
topic Obesity
vitamins
antioxidants
metabolism
description Introduction: Obesity is associated with the development of metabolic disorders that can be diagnosed through inflammatory and oxidative biomarkers.Background: This study evaluated the influence of obesity and overweight on serum concentrations of vitamins C and E, transforming growth factor beta 1 (TGF-β1) and cardiometabolic parameters.Methods: A cross-sectional study was conducted with 169 participants (24 normal weight, 16 overweight and 129 obese). Anthropometric measures and concentrations of vitamins C and E, thiobarbituric acid reactive substances (TBARS), TGF-β1, lipid profile, glycated hemoglobin (HbA1c), glucose and insulin were determined, and homeostatic model assessment of insulin resistance (HOMA-IR) and insulin sensitivity (IS) were calculated.Results: Obese and overweight participants showed significantly higher levels of TGF-β1, vitamin E, insulin, HbA1c, glucose, cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides, HOMA-IR, and TBARS compared with normal weight patients, associated with a significant reduction in IS, high-density lipoprotein cholesterol (HDL-c), and vitamin C.Conclusion: Obesity and overweight may lead to significant changes in TGF-B1, biochemical and oxidative markers. Increased levels of TGF-β1 may promote inflammation and interfere with IS. Reduced concentrations of vitamin C and increased levels of TBARS led to a redox imbalance in obese and overweight patients, suggesting that vitamin E is not a promising oxidative biomarker since it is lipophilic and its concentration is influenced by body fat. These results may help determine the oxidative and inflammatory pathways related to obesity and its comorbidities.Keywords: Obesity; vitamins; antioxidants; metabolism
publishDate 2018
dc.date.none.fl_str_mv 2018-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/79449
url https://seer.ufrgs.br/index.php/hcpa/article/view/79449
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/79449/pdf
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 38 No. 3 (2018): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 38 n. 3 (2018): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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