Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12

Detalhes bibliográficos
Autor(a) principal: Mattos, Liliane de Jesus
Data de Publicação: 2023
Outros Autores: Diniz, Júlia Breitenbach, Siqueira, Luciano de Oliveira
Tipo de documento: Artigo
Idioma: por
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/123482
Resumo: Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality.  58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed.
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spelling Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12Polineuropatia diabética assintomática induzida pelo uso crônico de metformina e sua correlação com a vitamina B12diabetes mellitusmetforminavitamina B12Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality.  58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed.Introdução: Diabetes Mellitus é doença metabólica, caracterizada pela deficiência absoluta ou relativa de insulina, que acomete cerca de 382 milhões de pessoas em todo mundo, tendo uma das complicações mais comuns a polineuropatia. A Metformina, medicamento amplamente utilizado como tratamento do Diabetes, foi descrita como responsável, em algumas literaturas, por causar ou agravar deficiência de vitamina B12, que está similarmente relacionada ao desenvolvimento de polineuropatia. Métodos: Nesse sentido, foi conduzido um estudo no município de Soledade – RS, com objetivo de verificar se essa relação é condizente com a realidade da localidade. Foram escolhidos 58 pacientes, dos quais 30 responderam questionários adaptadosbaseados na literatura e na Classificação de Neuropatia de Michigan (MNSS-Brasil), então colhidos 5 ml de sangue venoso da fossa antecubital, preparado soro do qual uma alíquota foi separada para determinação bioquímica da vitamina B12. Resultados: Analisando os resultados, a maioria dos pacientes analisados apresentou sintomas de polineuropatia, e 10% deste, deficiência vitamínica. Conclusão: nenhuma variável explicou a correlação do uso crônico da Metformina, dose e gênero com a deficiência da vitamina B12, o que indica que não há evidências fortes o suficiente que sustentem esse fato, de acordo com as particularidades da localidade analisada.HCPA/FAMED/UFRGS2023-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/123482Clinical & Biomedical Research; Vol. 43 No. 1 (2023): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 43 n. 1 (2023): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/123482/88718Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMattos, Liliane de Jesus Diniz, Júlia Breitenbach Siqueira, Luciano de Oliveira2024-01-19T14:11:35Zoai:seer.ufrgs.br:article/123482Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:11:35Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
Polineuropatia diabética assintomática induzida pelo uso crônico de metformina e sua correlação com a vitamina B12
title Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
spellingShingle Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
Mattos, Liliane de Jesus
diabetes mellitus
metformina
vitamina B12
title_short Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
title_full Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
title_fullStr Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
title_full_unstemmed Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
title_sort Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
author Mattos, Liliane de Jesus
author_facet Mattos, Liliane de Jesus
Diniz, Júlia Breitenbach
Siqueira, Luciano de Oliveira
author_role author
author2 Diniz, Júlia Breitenbach
Siqueira, Luciano de Oliveira
author2_role author
author
dc.contributor.author.fl_str_mv Mattos, Liliane de Jesus
Diniz, Júlia Breitenbach
Siqueira, Luciano de Oliveira
dc.subject.por.fl_str_mv diabetes mellitus
metformina
vitamina B12
topic diabetes mellitus
metformina
vitamina B12
description Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality.  58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
Avaliado por Pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/123482
url https://seer.ufrgs.br/index.php/hcpa/article/view/123482
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/123482/88718
dc.rights.driver.fl_str_mv Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueira
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueira
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 43 No. 1 (2023): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 43 n. 1 (2023): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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