Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/123482 |
Resumo: | Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality. 58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed. |
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Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12Polineuropatia diabética assintomática induzida pelo uso crônico de metformina e sua correlação com a vitamina B12diabetes mellitusmetforminavitamina B12Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality. 58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed.Introdução: Diabetes Mellitus é doença metabólica, caracterizada pela deficiência absoluta ou relativa de insulina, que acomete cerca de 382 milhões de pessoas em todo mundo, tendo uma das complicações mais comuns a polineuropatia. A Metformina, medicamento amplamente utilizado como tratamento do Diabetes, foi descrita como responsável, em algumas literaturas, por causar ou agravar deficiência de vitamina B12, que está similarmente relacionada ao desenvolvimento de polineuropatia. Métodos: Nesse sentido, foi conduzido um estudo no município de Soledade – RS, com objetivo de verificar se essa relação é condizente com a realidade da localidade. Foram escolhidos 58 pacientes, dos quais 30 responderam questionários adaptadosbaseados na literatura e na Classificação de Neuropatia de Michigan (MNSS-Brasil), então colhidos 5 ml de sangue venoso da fossa antecubital, preparado soro do qual uma alíquota foi separada para determinação bioquímica da vitamina B12. Resultados: Analisando os resultados, a maioria dos pacientes analisados apresentou sintomas de polineuropatia, e 10% deste, deficiência vitamínica. Conclusão: nenhuma variável explicou a correlação do uso crônico da Metformina, dose e gênero com a deficiência da vitamina B12, o que indica que não há evidências fortes o suficiente que sustentem esse fato, de acordo com as particularidades da localidade analisada.HCPA/FAMED/UFRGS2023-05-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por Paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/123482Clinical & Biomedical Research; Vol. 43 No. 1 (2023): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 43 n. 1 (2023): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSporhttps://seer.ufrgs.br/index.php/hcpa/article/view/123482/88718Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMattos, Liliane de Jesus Diniz, Júlia Breitenbach Siqueira, Luciano de Oliveira2024-01-19T14:11:35Zoai:seer.ufrgs.br:article/123482Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:11:35Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 Polineuropatia diabética assintomática induzida pelo uso crônico de metformina e sua correlação com a vitamina B12 |
title |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 |
spellingShingle |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 Mattos, Liliane de Jesus diabetes mellitus metformina vitamina B12 |
title_short |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 |
title_full |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 |
title_fullStr |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 |
title_full_unstemmed |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 |
title_sort |
Asymptomatic diabetic polyneuropathy induced by chronic metformin use and correlation with vitamin B12 |
author |
Mattos, Liliane de Jesus |
author_facet |
Mattos, Liliane de Jesus Diniz, Júlia Breitenbach Siqueira, Luciano de Oliveira |
author_role |
author |
author2 |
Diniz, Júlia Breitenbach Siqueira, Luciano de Oliveira |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Mattos, Liliane de Jesus Diniz, Júlia Breitenbach Siqueira, Luciano de Oliveira |
dc.subject.por.fl_str_mv |
diabetes mellitus metformina vitamina B12 |
topic |
diabetes mellitus metformina vitamina B12 |
description |
Diabetes Mellitus is a metabolic disease characterized by absolute or relative insulin deficiency, which affects about 382 million people, and it may have as a complication the Polyneuropathy. Vitamin B12 deficiency is also related to the development of polyneuropathy, and some literature describe that Metformin, a medicinal product widely used for diabetes control, may aggravate or even cause this deficiency. So, a study was conducted in Soledade - RS, aiming to verify whether this relationship is related to the reality of the locality. 58 patients were chosen, 30 of them answered adapted questionnaires based on the literature and the Michigan Neuropathy Classification (MNSS-Brazil), then collected 5 ml of venous blood from the antecubital fossa, and an aliquot from prepared serum to biochemical determination of vitamin B12. Analyzing the results, no variable explained the correlation between chronic use of Metformin to vitamin B12 deficiency, which indicates that there is not enough evidence to support this fact, according to the particularities of the locality analyzed. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por Pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/123482 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/123482 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/123482/88718 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueira https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Liliane de Jesus Mattos, Júlia Breitenbach Diniz, Luciano de Oliveira Siqueira https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 43 No. 1 (2023): Clinical and Biomedical Research Clinical and Biomedical Research; v. 43 n. 1 (2023): Clinical and Biomedical Research 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
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1799767056370892800 |