Factors associated to acute renal failure after hepatic transplant

• Autor(a) principal: R. Álvares-da-Silva, Mário
• Data de Publicação: 2022
• Outros Autores: L. Waechter, Fábio, L.O. Fonseca, Deise, Traiber, Cristiane, M. Zignani, Juliana, Sampaio, José A., D. Pinto, Rinaldo, Barros, Elvino, S. Thomé, Fernando, F. Francisconi, Carlos
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Clinical and Biomedical Research
• Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/124813
• topic: Acute renal failure; hepatic transplant; Insuficiência renal aguda; transplante hepático

OBJECTIVE: To evaluate the prevalence and the risk factors associated to the development of acute renal failure in patients submitted to liver transplant, at Hospitalde Clínicas de Porto Alegre from September 1996 to September 1998.PATIENTS AND METHODS: 36 patients that developed acute renal failure after liver transplant (group 1) were compared to those who did not develop acute renalfailure after liver transplant (group 2). The following factors were analyzed prior to surgery: etiology of the renal failure, classification of Child-Pugh, diabetes mellitus,and creatinine levels; during surgery: duration of warm ischemia, duration of surgery, duration of anesthesia; CHAD type of portocaval anastomosis; and after surgery: creatinine levels, infections, need for dialysis, duration of stay at the intensive care unit, cyclosporine levels, need for another intervention, and mortality. All data were evaluated during the first 7 days after surgery, with the exception of chronic renal failure and mortality, which were evaluated during a 3-month period.RESULTS: The prevalence of acute renal failure was high (approximately 49%). The presence of previous diabetes mellitus (P=0.03), the CHAD units used duringsurgery (P=0.046), the duration of stay at the intensive care unit (P=0.01), the surgical technique (P=0,04), and the need for another intervention (P=0.02), were allsignificantly associated to the development of acute renal failure after liver transplant in our sample. There was a significant level of mortality among patients that developed acute renal failure (P=0.02).CONCLUSIONS: We concluded that acute renal failure is a significant cause of mortality among patients submitted to hepatic transplant when associated to multiplerisk factors.