Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing

Detalhes bibliográficos
Autor(a) principal: Danilevicz, Chris Krebs
Data de Publicação: 2021
Outros Autores: Wagner, Vivian Petersen, Webber, Liana Preto, Schmidt, Tuany Rafaeli, Alonso, Ellen Cristine Pineze, de Mendonça, Elismauro Francisco, Valadares, Marize Campos, Marreto, Ricardo Neves, Martins, Manoela Domingues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinical and Biomedical Research
Texto Completo: https://seer.ufrgs.br/index.php/hcpa/article/view/100381
Resumo: Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.
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spelling Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healingCurcuminturmeric extractcurcuminoidphytotherapyphytomedicine.Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.HCPA/FAMED/UFRGS2021-02-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/100381Clinical & Biomedical Research; Vol. 40 No. 2 (2020): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 40 n. 2 (2020): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/100381/pdfCopyright (c) 2021 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessDanilevicz, Chris KrebsWagner, Vivian PetersenWebber, Liana PretoSchmidt, Tuany RafaeliAlonso, Ellen Cristine Pinezede Mendonça, Elismauro FranciscoValadares, Marize CamposMarreto, Ricardo NevesMartins, Manoela Domingues2024-01-19T14:21:14Zoai:seer.ufrgs.br:article/100381Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:21:14Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.none.fl_str_mv Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
title Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
spellingShingle Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
Danilevicz, Chris Krebs
Curcumin
turmeric extract
curcuminoid
phytotherapy
phytomedicine.
title_short Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
title_full Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
title_fullStr Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
title_full_unstemmed Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
title_sort Effects of a mucoadhesive formulation containing curcuma longa l. on oral wound healing
author Danilevicz, Chris Krebs
author_facet Danilevicz, Chris Krebs
Wagner, Vivian Petersen
Webber, Liana Preto
Schmidt, Tuany Rafaeli
Alonso, Ellen Cristine Pineze
de Mendonça, Elismauro Francisco
Valadares, Marize Campos
Marreto, Ricardo Neves
Martins, Manoela Domingues
author_role author
author2 Wagner, Vivian Petersen
Webber, Liana Preto
Schmidt, Tuany Rafaeli
Alonso, Ellen Cristine Pineze
de Mendonça, Elismauro Francisco
Valadares, Marize Campos
Marreto, Ricardo Neves
Martins, Manoela Domingues
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Danilevicz, Chris Krebs
Wagner, Vivian Petersen
Webber, Liana Preto
Schmidt, Tuany Rafaeli
Alonso, Ellen Cristine Pineze
de Mendonça, Elismauro Francisco
Valadares, Marize Campos
Marreto, Ricardo Neves
Martins, Manoela Domingues
dc.subject.por.fl_str_mv Curcumin
turmeric extract
curcuminoid
phytotherapy
phytomedicine.
topic Curcumin
turmeric extract
curcuminoid
phytotherapy
phytomedicine.
description Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/100381
url https://seer.ufrgs.br/index.php/hcpa/article/view/100381
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://seer.ufrgs.br/index.php/hcpa/article/view/100381/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2021 Clinical and Biomedical Research
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Clinical and Biomedical Research
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv HCPA/FAMED/UFRGS
publisher.none.fl_str_mv HCPA/FAMED/UFRGS
dc.source.none.fl_str_mv Clinical & Biomedical Research; Vol. 40 No. 2 (2020): Clinical and Biomedical Research
Clinical and Biomedical Research; v. 40 n. 2 (2020): Clinical and Biomedical Research
2357-9730
reponame:Clinical and Biomedical Research
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Clinical and Biomedical Research
collection Clinical and Biomedical Research
repository.name.fl_str_mv Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)
repository.mail.fl_str_mv ||cbr@hcpa.edu.br
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