MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinical and Biomedical Research |
Texto Completo: | https://seer.ufrgs.br/index.php/hcpa/article/view/101171 |
Resumo: | A case report of a patient with pseudo bulbar affect previous treatments included haloperidol (10mg), Inosina pranobex (600mg), clozapine (600mg), olanzapine (20mg), carbamazepine (200mg), paroxetine (20mg), phenobarbital (100mg) and topiramate (50mg), all suspended at August 2016, with current use of quetiapine (700mg) Chlorpromazine (600mg) (+ 200mg on demand of aggression), clonazepam (4 mg), valproate 2500 mg, propranolol (40mg). that was successful treated with off label treatment (dextromethorphan plus quinidine). Previous Brief Psychiatric Rating Scale and Clinical Global ImpressionImprovement was applied after and before treatment with dextromethorphan (20mg) plus fluoxetine (20 mg, further increased to 40 mg). Previous Brief Psychiatric Rating Scale BPRS score 56 points and Clinical Global Impression-Severity (CGI-S) Score was 6 (severely ill). The addition of dextromethorphan (20mg) and fluoxetine (20 mg, further increased to 40 mg), allowed clear improvement of pathological crying and outbursts, with BPRS decrease of 8 points and Clinical Global Impression-Improvement (CGI-I) 2 (much improved) – especially pertaining to PBA related symptoms and aggressive behavior. There were no noticeable side-effects. This case report shown an interesting clinical response. It’s could be a great alternative in treatment of pseudobulbar affect symptoms. Even though an only case and a great clinical study be necessary. |
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Clinical and Biomedical Research |
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spelling |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINENeurologygenetic syndromeoff label medicinebehaviorA case report of a patient with pseudo bulbar affect previous treatments included haloperidol (10mg), Inosina pranobex (600mg), clozapine (600mg), olanzapine (20mg), carbamazepine (200mg), paroxetine (20mg), phenobarbital (100mg) and topiramate (50mg), all suspended at August 2016, with current use of quetiapine (700mg) Chlorpromazine (600mg) (+ 200mg on demand of aggression), clonazepam (4 mg), valproate 2500 mg, propranolol (40mg). that was successful treated with off label treatment (dextromethorphan plus quinidine). Previous Brief Psychiatric Rating Scale and Clinical Global ImpressionImprovement was applied after and before treatment with dextromethorphan (20mg) plus fluoxetine (20 mg, further increased to 40 mg). Previous Brief Psychiatric Rating Scale BPRS score 56 points and Clinical Global Impression-Severity (CGI-S) Score was 6 (severely ill). The addition of dextromethorphan (20mg) and fluoxetine (20 mg, further increased to 40 mg), allowed clear improvement of pathological crying and outbursts, with BPRS decrease of 8 points and Clinical Global Impression-Improvement (CGI-I) 2 (much improved) – especially pertaining to PBA related symptoms and aggressive behavior. There were no noticeable side-effects. This case report shown an interesting clinical response. It’s could be a great alternative in treatment of pseudobulbar affect symptoms. Even though an only case and a great clinical study be necessary.HCPA/FAMED/UFRGS2021-03-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed ArticleAvaliado por paresapplication/pdfhttps://seer.ufrgs.br/index.php/hcpa/article/view/101171Clinical & Biomedical Research; Vol. 40 No. 3 (2020): Clinical and Biomedical ResearchClinical and Biomedical Research; v. 40 n. 3 (2020): Clinical and Biomedical Research2357-9730reponame:Clinical and Biomedical Researchinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/hcpa/article/view/101171/pdfCopyright (c) 2021 Clinical and Biomedical Researchinfo:eu-repo/semantics/openAccessCordova, Victor HugoGoldani, AndréBelmonte-de-Abreu, Paulo2024-01-19T14:21:04Zoai:seer.ufrgs.br:article/101171Revistahttps://www.seer.ufrgs.br/index.php/hcpaPUBhttps://seer.ufrgs.br/index.php/hcpa/oai||cbr@hcpa.edu.br2357-97302357-9730opendoar:2024-01-19T14:21:04Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.none.fl_str_mv |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
title |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
spellingShingle |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE Cordova, Victor Hugo Neurology genetic syndrome off label medicine behavior |
title_short |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
title_full |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
title_fullStr |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
title_full_unstemmed |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
title_sort |
MANAGEMENT OF THE PSEUDOBULBAR AFFECT (PBA) IN KABUKI SYNDROME COMBINED DEXTROMETHORPHAN-FLUOXETINE TREATMENT AS AN ALTERNATIVE TO DEXTROMETHORPHAN/QUINIDINE |
author |
Cordova, Victor Hugo |
author_facet |
Cordova, Victor Hugo Goldani, André Belmonte-de-Abreu, Paulo |
author_role |
author |
author2 |
Goldani, André Belmonte-de-Abreu, Paulo |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Cordova, Victor Hugo Goldani, André Belmonte-de-Abreu, Paulo |
dc.subject.por.fl_str_mv |
Neurology genetic syndrome off label medicine behavior |
topic |
Neurology genetic syndrome off label medicine behavior |
description |
A case report of a patient with pseudo bulbar affect previous treatments included haloperidol (10mg), Inosina pranobex (600mg), clozapine (600mg), olanzapine (20mg), carbamazepine (200mg), paroxetine (20mg), phenobarbital (100mg) and topiramate (50mg), all suspended at August 2016, with current use of quetiapine (700mg) Chlorpromazine (600mg) (+ 200mg on demand of aggression), clonazepam (4 mg), valproate 2500 mg, propranolol (40mg). that was successful treated with off label treatment (dextromethorphan plus quinidine). Previous Brief Psychiatric Rating Scale and Clinical Global ImpressionImprovement was applied after and before treatment with dextromethorphan (20mg) plus fluoxetine (20 mg, further increased to 40 mg). Previous Brief Psychiatric Rating Scale BPRS score 56 points and Clinical Global Impression-Severity (CGI-S) Score was 6 (severely ill). The addition of dextromethorphan (20mg) and fluoxetine (20 mg, further increased to 40 mg), allowed clear improvement of pathological crying and outbursts, with BPRS decrease of 8 points and Clinical Global Impression-Improvement (CGI-I) 2 (much improved) – especially pertaining to PBA related symptoms and aggressive behavior. There were no noticeable side-effects. This case report shown an interesting clinical response. It’s could be a great alternative in treatment of pseudobulbar affect symptoms. Even though an only case and a great clinical study be necessary. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03-11 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Avaliado por pares |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/101171 |
url |
https://seer.ufrgs.br/index.php/hcpa/article/view/101171 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufrgs.br/index.php/hcpa/article/view/101171/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Clinical and Biomedical Research info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Clinical and Biomedical Research |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
publisher.none.fl_str_mv |
HCPA/FAMED/UFRGS |
dc.source.none.fl_str_mv |
Clinical & Biomedical Research; Vol. 40 No. 3 (2020): Clinical and Biomedical Research Clinical and Biomedical Research; v. 40 n. 3 (2020): Clinical and Biomedical Research 2357-9730 reponame:Clinical and Biomedical Research instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Clinical and Biomedical Research |
collection |
Clinical and Biomedical Research |
repository.name.fl_str_mv |
Clinical and Biomedical Research - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
||cbr@hcpa.edu.br |
_version_ |
1799767055684075520 |