Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21157 |
Resumo: | The reasons for the inconsistent association between salt consumption and blood pressure levels observed in within-society surveys are not known. A total of 157 normotensive subjects aged 18 to 35 years, selected at random in a cross-sectional population-based survey, answered a structured questionnaire. They were classified as strongly predisposed to hypertension when two or more first-degree relatives had a diagnosis of hypertension. Anthropometric parameters were obtained and sitting blood pressure was determined with aneroid sphygmomanometers. Sodium and potassium excretion was measured by flame spectrophotometry in an overnight urine sample. A positive correlation between blood pressure and urinary sodium excretion was detected only in the group of individuals strongly predisposed to hypertension, both for systolic blood pressure (r = 0.51, P<0.01) and diastolic blood pressure (r = 0.50, P<0.01). In a covariance analysis, after controlling for age, skin color and body mass index, individuals strongly predisposed to hypertension who excreted amounts of sodium above the median of the entire sample had higher systolic and diastolic blood pressure than subjects classified into the remaining conditions. The influence of familial predisposition to hypertension on the association between salt intake and blood pressure may be an additional explanation for the weak association between urinary sodium excretion and blood pressure observed in within-population studies, since it can influence the association between salt consumption and blood pressure in some but not all inhabitants. |
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Moraes, Renan StollFuchs, Flávio DanniCosta, Francisco DallaMoreira, Leila Beltrami2010-04-24T04:15:31Z20000100-879Xhttp://hdl.handle.net/10183/21157000295739The reasons for the inconsistent association between salt consumption and blood pressure levels observed in within-society surveys are not known. A total of 157 normotensive subjects aged 18 to 35 years, selected at random in a cross-sectional population-based survey, answered a structured questionnaire. They were classified as strongly predisposed to hypertension when two or more first-degree relatives had a diagnosis of hypertension. Anthropometric parameters were obtained and sitting blood pressure was determined with aneroid sphygmomanometers. Sodium and potassium excretion was measured by flame spectrophotometry in an overnight urine sample. A positive correlation between blood pressure and urinary sodium excretion was detected only in the group of individuals strongly predisposed to hypertension, both for systolic blood pressure (r = 0.51, P<0.01) and diastolic blood pressure (r = 0.50, P<0.01). In a covariance analysis, after controlling for age, skin color and body mass index, individuals strongly predisposed to hypertension who excreted amounts of sodium above the median of the entire sample had higher systolic and diastolic blood pressure than subjects classified into the remaining conditions. The influence of familial predisposition to hypertension on the association between salt intake and blood pressure may be an additional explanation for the weak association between urinary sodium excretion and blood pressure observed in within-population studies, since it can influence the association between salt consumption and blood pressure in some but not all inhabitants.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 7 (July 2000), p. 799-803HipertensãoGenéticaFatores de riscoCloreto de sódio na dietaHypertensionFamilial predisposition to hypertensionUrinary sodium excretionSalt sensitivityFamilial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adultsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000295739.pdf000295739.pdfTexto completo (inglês)application/pdf88224http://www.lume.ufrgs.br/bitstream/10183/21157/1/000295739.pdf6a9975d6c0431cf73ca6f5f8d755ddd2MD51TEXT000295739.pdf.txt000295739.pdf.txtExtracted Texttext/plain20195http://www.lume.ufrgs.br/bitstream/10183/21157/2/000295739.pdf.txt75fd2bad4e98129647c3d5a6cc41bb1bMD52THUMBNAIL000295739.pdf.jpg000295739.pdf.jpgGenerated Thumbnailimage/jpeg1585http://www.lume.ufrgs.br/bitstream/10183/21157/3/000295739.pdf.jpgcf8078b8da65631c22fbc42bb4a14069MD5310183/211572023-06-30 03:33:58.105314oai:www.lume.ufrgs.br:10183/21157Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-06-30T06:33:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
title |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
spellingShingle |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults Moraes, Renan Stoll Hipertensão Genética Fatores de risco Cloreto de sódio na dieta Hypertension Familial predisposition to hypertension Urinary sodium excretion Salt sensitivity |
title_short |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
title_full |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
title_fullStr |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
title_full_unstemmed |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
title_sort |
Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults |
author |
Moraes, Renan Stoll |
author_facet |
Moraes, Renan Stoll Fuchs, Flávio Danni Costa, Francisco Dalla Moreira, Leila Beltrami |
author_role |
author |
author2 |
Fuchs, Flávio Danni Costa, Francisco Dalla Moreira, Leila Beltrami |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Moraes, Renan Stoll Fuchs, Flávio Danni Costa, Francisco Dalla Moreira, Leila Beltrami |
dc.subject.por.fl_str_mv |
Hipertensão Genética Fatores de risco Cloreto de sódio na dieta |
topic |
Hipertensão Genética Fatores de risco Cloreto de sódio na dieta Hypertension Familial predisposition to hypertension Urinary sodium excretion Salt sensitivity |
dc.subject.eng.fl_str_mv |
Hypertension Familial predisposition to hypertension Urinary sodium excretion Salt sensitivity |
description |
The reasons for the inconsistent association between salt consumption and blood pressure levels observed in within-society surveys are not known. A total of 157 normotensive subjects aged 18 to 35 years, selected at random in a cross-sectional population-based survey, answered a structured questionnaire. They were classified as strongly predisposed to hypertension when two or more first-degree relatives had a diagnosis of hypertension. Anthropometric parameters were obtained and sitting blood pressure was determined with aneroid sphygmomanometers. Sodium and potassium excretion was measured by flame spectrophotometry in an overnight urine sample. A positive correlation between blood pressure and urinary sodium excretion was detected only in the group of individuals strongly predisposed to hypertension, both for systolic blood pressure (r = 0.51, P<0.01) and diastolic blood pressure (r = 0.50, P<0.01). In a covariance analysis, after controlling for age, skin color and body mass index, individuals strongly predisposed to hypertension who excreted amounts of sodium above the median of the entire sample had higher systolic and diastolic blood pressure than subjects classified into the remaining conditions. The influence of familial predisposition to hypertension on the association between salt intake and blood pressure may be an additional explanation for the weak association between urinary sodium excretion and blood pressure observed in within-population studies, since it can influence the association between salt consumption and blood pressure in some but not all inhabitants. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:31Z |
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http://hdl.handle.net/10183/21157 |
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0100-879X |
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000295739 |
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http://hdl.handle.net/10183/21157 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 33, no. 7 (July 2000), p. 799-803 |
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openAccess |
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