Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/218912 |
Resumo: | Introduction To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records. Results Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) administration and 28 (28.6 %) received IV and IM administrations. The occurrence of allergic reactions differed between the groups (p < 0.001), and IV administration was associated with allergic reactions. Association was also observed between the severity of the reaction and the route of administration, with the IM route associated with grade 2 and IV route associated with grade 3. Occurrence of allergic reactions was higher when the commercial formulation of l-ASP, Leuginase®, was used (p = 0.0009 in the analysis per patient and p = 0.0003 in the analysis per administration). Conclusions The IV administration and commercial Leuginase® presentation were associated with more allergic reactions in the study population, which corroborates the findings in the literature. The IV route was also associated with higher severity of reactions in the present study. |
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Battistel, Ana PaulaRocha, Bruno Simas daSantos, Maitê Telles dosDaudt, Liane EstevesMichalowski, Mariana Bohns2021-03-16T04:26:23Z20212531-1379http://hdl.handle.net/10183/218912001123251Introduction To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records. Results Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) administration and 28 (28.6 %) received IV and IM administrations. The occurrence of allergic reactions differed between the groups (p < 0.001), and IV administration was associated with allergic reactions. Association was also observed between the severity of the reaction and the route of administration, with the IM route associated with grade 2 and IV route associated with grade 3. Occurrence of allergic reactions was higher when the commercial formulation of l-ASP, Leuginase®, was used (p = 0.0009 in the analysis per patient and p = 0.0003 in the analysis per administration). Conclusions The IV administration and commercial Leuginase® presentation were associated with more allergic reactions in the study population, which corroborates the findings in the literature. The IV route was also associated with higher severity of reactions in the present study.application/pdfengHematology, transfusion and cell therapy. Rio de Janeiro. Vol. 43, no.1 (2021), p. 9-14Leucemia-linfoma linfoblástico de células precursorasCriançaAsparaginaseHipersensibilidadeFatores de riscoAcute lymphoblastic leukemiaAsparaginaseHypersensitivityChildrenAllergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemiainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001123251.pdf.txt001123251.pdf.txtExtracted Texttext/plain28826http://www.lume.ufrgs.br/bitstream/10183/218912/2/001123251.pdf.txt54b77a745d9ee107db07fda835800102MD52ORIGINAL001123251.pdfTexto completo (inglês)application/pdf583649http://www.lume.ufrgs.br/bitstream/10183/218912/1/001123251.pdf56d20b4a458dd5e90c6e6e1deac673e4MD5110183/2189122023-03-24 03:23:07.603663oai:www.lume.ufrgs.br:10183/218912Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-03-24T06:23:07Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
title |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
spellingShingle |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia Battistel, Ana Paula Leucemia-linfoma linfoblástico de células precursoras Criança Asparaginase Hipersensibilidade Fatores de risco Acute lymphoblastic leukemia Asparaginase Hypersensitivity Children |
title_short |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
title_full |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
title_fullStr |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
title_full_unstemmed |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
title_sort |
Allergic reactions to asparaginase : retrospective cohort study in pediatric patients with acute lymphoid leukemia |
author |
Battistel, Ana Paula |
author_facet |
Battistel, Ana Paula Rocha, Bruno Simas da Santos, Maitê Telles dos Daudt, Liane Esteves Michalowski, Mariana Bohns |
author_role |
author |
author2 |
Rocha, Bruno Simas da Santos, Maitê Telles dos Daudt, Liane Esteves Michalowski, Mariana Bohns |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Battistel, Ana Paula Rocha, Bruno Simas da Santos, Maitê Telles dos Daudt, Liane Esteves Michalowski, Mariana Bohns |
dc.subject.por.fl_str_mv |
Leucemia-linfoma linfoblástico de células precursoras Criança Asparaginase Hipersensibilidade Fatores de risco |
topic |
Leucemia-linfoma linfoblástico de células precursoras Criança Asparaginase Hipersensibilidade Fatores de risco Acute lymphoblastic leukemia Asparaginase Hypersensitivity Children |
dc.subject.eng.fl_str_mv |
Acute lymphoblastic leukemia Asparaginase Hypersensitivity Children |
description |
Introduction To assess the frequency of allergic reactions to asparaginase (ASP) and possible risk factors for reactions in a cohort of pediatric patients. Method The study was performed based on retrospective data from patients under acute lymphoid leukemia treatment in a general university hospital located in southern Brazil. Information on patients who used ASP from 2010 to 2017 was collected. Allergic reactions were identified in electronic medical records. Results Among the 98 patients included in the study, 16 (16.3 %) experienced an allergic reaction to native l-asparaginase (L-ASP). Of the 22 patients (22.4 %) that received only intravenous (IV) administration of l-ASP, 10 (62.5 %) had allergic reactions, while 48 patients (49 %) received intramuscular (IM) administration and 28 (28.6 %) received IV and IM administrations. The occurrence of allergic reactions differed between the groups (p < 0.001), and IV administration was associated with allergic reactions. Association was also observed between the severity of the reaction and the route of administration, with the IM route associated with grade 2 and IV route associated with grade 3. Occurrence of allergic reactions was higher when the commercial formulation of l-ASP, Leuginase®, was used (p = 0.0009 in the analysis per patient and p = 0.0003 in the analysis per administration). Conclusions The IV administration and commercial Leuginase® presentation were associated with more allergic reactions in the study population, which corroborates the findings in the literature. The IV route was also associated with higher severity of reactions in the present study. |
publishDate |
2021 |
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2021-03-16T04:26:23Z |
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001123251 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Hematology, transfusion and cell therapy. Rio de Janeiro. Vol. 43, no.1 (2021), p. 9-14 |
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