Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/224678 |
Resumo: | Fungal infections have emerged as a current serious global public health problem. Themain probleminvolving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM= 19.14 μg ml−1)). However, compounds 2 (GM= 50 μg ml−1) and 3 (GM=47.19 μg ml−1) have presented only anti- Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. |
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Machado, Gabriella da Rosa MonteDiedrich, DeniseRuaro, Thais CarineZimmer, Aline RigonTeixeira, Mário LettieriOliveira, Luis Flávio Souza deVan de Weghe, PierreJean, MichaelAndrade, Saulo Fernandes deGnoatto, Simone Cristina BaggioFuentefria, Alexandre Meneghello2021-07-28T04:41:18Z20201517-8382http://hdl.handle.net/10183/224678001123468Fungal infections have emerged as a current serious global public health problem. Themain probleminvolving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM= 19.14 μg ml−1)). However, compounds 2 (GM= 50 μg ml−1) and 3 (GM=47.19 μg ml−1) have presented only anti- Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment.application/pdfporBrazilian journal of microbiology. Sao Paulo, SP. Vol. 51, n.4, (dez. 2020), p. 1691-1701TinhaDermatófitosCandidaCompostos químicos : análiseQuinolinasAntifúngicosToxicologiaDermatophyteAntifungal potentialQuinoline derivativesFungal resistanceQuinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosisRevista de Microbiologia Estrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001123468.pdf.txt001123468.pdf.txtExtracted Texttext/plain51797http://www.lume.ufrgs.br/bitstream/10183/224678/2/001123468.pdf.txta99cc37fbfa1bc005b1a5a82b439cce2MD52ORIGINAL001123468.pdfTexto completo (inglês)application/pdf1000504http://www.lume.ufrgs.br/bitstream/10183/224678/1/001123468.pdf3c73e8f60f3fd91c94387c148db9bb45MD5110183/2246782021-08-18 04:51:04.934974oai:www.lume.ufrgs.br:10183/224678Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-08-18T07:51:04Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
dc.title.alternative.pt_BR.fl_str_mv |
Revista de Microbiologia |
title |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
spellingShingle |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis Machado, Gabriella da Rosa Monte Tinha Dermatófitos Candida Compostos químicos : análise Quinolinas Antifúngicos Toxicologia Dermatophyte Antifungal potential Quinoline derivatives Fungal resistance |
title_short |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_full |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_fullStr |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_full_unstemmed |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
title_sort |
Quinolines derivatives as promising new antifungal candidates for the treatment of candidiasis and dermatophytosis |
author |
Machado, Gabriella da Rosa Monte |
author_facet |
Machado, Gabriella da Rosa Monte Diedrich, Denise Ruaro, Thais Carine Zimmer, Aline Rigon Teixeira, Mário Lettieri Oliveira, Luis Flávio Souza de Van de Weghe, Pierre Jean, Michael Andrade, Saulo Fernandes de Gnoatto, Simone Cristina Baggio Fuentefria, Alexandre Meneghello |
author_role |
author |
author2 |
Diedrich, Denise Ruaro, Thais Carine Zimmer, Aline Rigon Teixeira, Mário Lettieri Oliveira, Luis Flávio Souza de Van de Weghe, Pierre Jean, Michael Andrade, Saulo Fernandes de Gnoatto, Simone Cristina Baggio Fuentefria, Alexandre Meneghello |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Gabriella da Rosa Monte Diedrich, Denise Ruaro, Thais Carine Zimmer, Aline Rigon Teixeira, Mário Lettieri Oliveira, Luis Flávio Souza de Van de Weghe, Pierre Jean, Michael Andrade, Saulo Fernandes de Gnoatto, Simone Cristina Baggio Fuentefria, Alexandre Meneghello |
dc.subject.por.fl_str_mv |
Tinha Dermatófitos Candida Compostos químicos : análise Quinolinas Antifúngicos Toxicologia |
topic |
Tinha Dermatófitos Candida Compostos químicos : análise Quinolinas Antifúngicos Toxicologia Dermatophyte Antifungal potential Quinoline derivatives Fungal resistance |
dc.subject.eng.fl_str_mv |
Dermatophyte Antifungal potential Quinoline derivatives Fungal resistance |
description |
Fungal infections have emerged as a current serious global public health problem. Themain probleminvolving these infections is the expansion of multidrug resistance. Therefore, the prospection of new compounds with efficacy antifungal becomes necessary. Thus, this study evaluated the antifungal profile and toxicological parameters of quinolines derivatives against Candida spp. and dermatophyte strains. As a result, a selective anti-dermatophytic action was demonstrated by compound 5 (geometric means (GM= 19.14 μg ml−1)). However, compounds 2 (GM= 50 μg ml−1) and 3 (GM=47.19 μg ml−1) have presented only anti- Candida action. Compounds 3 and 5 did not present cytotoxic action. Compound 5 did not produce dermal and mucosal toxicity. In addition, this compound showed the absence of genotoxic potential, suggesting safety for topical and systemic use. Quinolines demonstrated a potent anti-dermatophytic and anti-yeast action. Moreover, compound 5 presented an excellent toxicological profile, acting as a strong candidate for the development of a new effective and safe compound against dermatophytosis of difficult treatment. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-07-28T04:41:18Z |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/224678 |
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1517-8382 |
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001123468 |
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http://hdl.handle.net/10183/224678 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of microbiology. Sao Paulo, SP. Vol. 51, n.4, (dez. 2020), p. 1691-1701 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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