Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21131 |
Resumo: | High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD. |
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Simon, DanielPaludo, Crislaine A.Ghisleni, Gabriele CordenonziManfroi, Waldomiro CarlosRoisenberg, Israel2010-04-24T04:15:27Z20030100-879Xhttp://hdl.handle.net/10183/21131000376546High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD.application/pdfengBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 36, no. 6 (June 2003), p. 709-714Doenças cardiovascularesFatores de riscoVon Willebrand factorCoronary artery diseaseDNA polymorphismsRisk factorAssociation studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery diseaseinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000376546.pdf000376546.pdfTexto completo (inglês)application/pdf481037http://www.lume.ufrgs.br/bitstream/10183/21131/1/000376546.pdf8fd978af612910a9473d86ea1895637bMD51TEXT000376546.pdf.txt000376546.pdf.txtExtracted Texttext/plain22444http://www.lume.ufrgs.br/bitstream/10183/21131/2/000376546.pdf.txtaa4ee51e18c1bd66713257d3429323bfMD52THUMBNAIL000376546.pdf.jpg000376546.pdf.jpgGenerated Thumbnailimage/jpeg1754http://www.lume.ufrgs.br/bitstream/10183/21131/3/000376546.pdf.jpg9b2534ffe67fcad35553cdf735395896MD5310183/211312018-10-08 08:05:56.103oai:www.lume.ufrgs.br:10183/21131Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-08T11:05:56Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
title |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
spellingShingle |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease Simon, Daniel Doenças cardiovasculares Fatores de risco Von Willebrand factor Coronary artery disease DNA polymorphisms Risk factor |
title_short |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
title_full |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
title_fullStr |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
title_full_unstemmed |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
title_sort |
Association studies between -1185A/G von Willebrand factor gene polymorphism and coronary artery disease |
author |
Simon, Daniel |
author_facet |
Simon, Daniel Paludo, Crislaine A. Ghisleni, Gabriele Cordenonzi Manfroi, Waldomiro Carlos Roisenberg, Israel |
author_role |
author |
author2 |
Paludo, Crislaine A. Ghisleni, Gabriele Cordenonzi Manfroi, Waldomiro Carlos Roisenberg, Israel |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Simon, Daniel Paludo, Crislaine A. Ghisleni, Gabriele Cordenonzi Manfroi, Waldomiro Carlos Roisenberg, Israel |
dc.subject.por.fl_str_mv |
Doenças cardiovasculares Fatores de risco |
topic |
Doenças cardiovasculares Fatores de risco Von Willebrand factor Coronary artery disease DNA polymorphisms Risk factor |
dc.subject.eng.fl_str_mv |
Von Willebrand factor Coronary artery disease DNA polymorphisms Risk factor |
description |
High levels of von Willebrand factor (vWF) have been associated with cardiovascular disease. The A allele of the -1185A/G polymorphism in the 5'-regulatory region of the vWF gene was associated with the highest plasma vWF levels in a normal population. To examine the association between -1185A/G polymorphism and coronary artery disease (CAD), 173 Brazilian Caucasian subjects submitted to coronary angiography were studied. Of these, 57 (33%) had normal coronary arteries (control group) and 116 (67%) had CAD (patient group). Plasma vWF levels were higher in patients (145 U/dl) than in controls (130 U/dl), but the differences were significant only for O blood group subjects. Polymerase chain reaction amplification of the 864-bp vWF promoter region followed by AccII restriction digestion was used to identify the -1185A/G genotypes. The -1185A allele frequency was 43.1% in patients and 44.7% in controls. Allele and genotype frequencies were not significantly different between patients and controls. No association was observed between the -1185A/G genotypes and plasma vWF levels in patients or controls. These results suggest that -1185A/G polymorphism is not an independent risk factor for CAD. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:27Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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0100-879X |
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000376546 |
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eng |
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Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 36, no. 6 (June 2003), p. 709-714 |
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