Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/262362 |
Resumo: | The purpose of this study was to extract, identify, and quantify the phenolic compounds in grumixama (Eugenia brasilienses Lam.) and guabiju (Myrcianthes pungens), native fruits from southern region of Brazil, and to explore their antioxidant and anti-inflammatory properties. The phenolic compounds were extracted with acidified water and acidified methanol and evaluated for their bioactive constituents, antioxidant capacity, and anti-inflammatory properties. Spectrophotometric quantification shows tannins to be the most prevalent at 2.3 to 5.8 g/100g fresh fruit with acidified methanol containing higher concentrations of different phenolics than acidified water. HPLC analysis indicates that gallic acid, catechin, vanillic acid, and ellagic acid are the most prevalent phenolics in the two fruits extracts. Scavenging of DPPH and NO radicals showed inhibition by as much as 95% and 80%, respectively, at 2.5 gallic acid equivalent (GAE)/mL of the extract. At 50 μg GAE/mL, the release of proinflammatory molecules NO and IL-6 was significantly reduced with acidified methanol extract having higher inhibitory activity. Our results revealed that these native fruits, grown in the south of Brazil, are rich sources of phenolic compounds and have great antioxidant and anti-inflammatory activity. |
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Tischer, BrunaPangloli, PhilipusNieto-Veloza, Cindy AndreaReeder, MatthewDia, Vermont Punongbayan2023-07-19T03:40:43Z20231932-6203http://hdl.handle.net/10183/262362001169215The purpose of this study was to extract, identify, and quantify the phenolic compounds in grumixama (Eugenia brasilienses Lam.) and guabiju (Myrcianthes pungens), native fruits from southern region of Brazil, and to explore their antioxidant and anti-inflammatory properties. The phenolic compounds were extracted with acidified water and acidified methanol and evaluated for their bioactive constituents, antioxidant capacity, and anti-inflammatory properties. Spectrophotometric quantification shows tannins to be the most prevalent at 2.3 to 5.8 g/100g fresh fruit with acidified methanol containing higher concentrations of different phenolics than acidified water. HPLC analysis indicates that gallic acid, catechin, vanillic acid, and ellagic acid are the most prevalent phenolics in the two fruits extracts. Scavenging of DPPH and NO radicals showed inhibition by as much as 95% and 80%, respectively, at 2.5 gallic acid equivalent (GAE)/mL of the extract. At 50 μg GAE/mL, the release of proinflammatory molecules NO and IL-6 was significantly reduced with acidified methanol extract having higher inhibitory activity. Our results revealed that these native fruits, grown in the south of Brazil, are rich sources of phenolic compounds and have great antioxidant and anti-inflammatory activity.application/pdfengPloS one. San Francisco. Vol. 18, no. 5 (May 2023), e0285625, 16 p.Compostos bioativosAtividade antioxidanteFruta nativa : Brasil, Região SulAtividade anti-inflamatóriaBioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from BrazilEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001169215.pdf.txt001169215.pdf.txtExtracted Texttext/plain59303http://www.lume.ufrgs.br/bitstream/10183/262362/2/001169215.pdf.txt712a1b4dca56258e43af17b502f711dcMD52ORIGINAL001169215.pdfTexto completo (inglês)application/pdf1276783http://www.lume.ufrgs.br/bitstream/10183/262362/1/001169215.pdf6bdec6a6bcae67b863c59dbb2a1ea544MD5110183/2623622023-09-24 03:39:11.850742oai:www.lume.ufrgs.br:10183/262362Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-24T06:39:11Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
title |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
spellingShingle |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil Tischer, Bruna Compostos bioativos Atividade antioxidante Fruta nativa : Brasil, Região Sul Atividade anti-inflamatória |
title_short |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
title_full |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
title_fullStr |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
title_full_unstemmed |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
title_sort |
Bioactive compounds, antioxidant capacity and anti-inflammatory activity of native fruits from Brazil |
author |
Tischer, Bruna |
author_facet |
Tischer, Bruna Pangloli, Philipus Nieto-Veloza, Cindy Andrea Reeder, Matthew Dia, Vermont Punongbayan |
author_role |
author |
author2 |
Pangloli, Philipus Nieto-Veloza, Cindy Andrea Reeder, Matthew Dia, Vermont Punongbayan |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Tischer, Bruna Pangloli, Philipus Nieto-Veloza, Cindy Andrea Reeder, Matthew Dia, Vermont Punongbayan |
dc.subject.por.fl_str_mv |
Compostos bioativos Atividade antioxidante Fruta nativa : Brasil, Região Sul Atividade anti-inflamatória |
topic |
Compostos bioativos Atividade antioxidante Fruta nativa : Brasil, Região Sul Atividade anti-inflamatória |
description |
The purpose of this study was to extract, identify, and quantify the phenolic compounds in grumixama (Eugenia brasilienses Lam.) and guabiju (Myrcianthes pungens), native fruits from southern region of Brazil, and to explore their antioxidant and anti-inflammatory properties. The phenolic compounds were extracted with acidified water and acidified methanol and evaluated for their bioactive constituents, antioxidant capacity, and anti-inflammatory properties. Spectrophotometric quantification shows tannins to be the most prevalent at 2.3 to 5.8 g/100g fresh fruit with acidified methanol containing higher concentrations of different phenolics than acidified water. HPLC analysis indicates that gallic acid, catechin, vanillic acid, and ellagic acid are the most prevalent phenolics in the two fruits extracts. Scavenging of DPPH and NO radicals showed inhibition by as much as 95% and 80%, respectively, at 2.5 gallic acid equivalent (GAE)/mL of the extract. At 50 μg GAE/mL, the release of proinflammatory molecules NO and IL-6 was significantly reduced with acidified methanol extract having higher inhibitory activity. Our results revealed that these native fruits, grown in the south of Brazil, are rich sources of phenolic compounds and have great antioxidant and anti-inflammatory activity. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-07-19T03:40:43Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/262362 |
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1932-6203 |
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001169215 |
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http://hdl.handle.net/10183/262362 |
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eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PloS one. San Francisco. Vol. 18, no. 5 (May 2023), e0285625, 16 p. |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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