Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/111612 |
Resumo: | Background: The relationship between uncoupling protein (UCP) 1–3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. However, the impact of these polymorphisms on obesity is still under debate, with contradictory results being reported. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability. Thus, this paper describe a meta-analysis conducted to evaluate if the -3826A/G (UCP1); - 866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3) polymorphisms are associated with BMI changes. Methods: A literature search was run to identify all studies that investigated associations between UCP1-3 polymorphisms and BMI. Weighted mean differences (WMD) were calculated for different inheritance models. Results: Fifty-six studies were eligible for inclusion in the meta-analysis. Meta-analysis results showed that UCP2 55Val/Val genotype was associated with increased BMI in Europeans [Random Effect Model (REM) WMD 0.81, 95% CI 0.20, 1.41]. Moreover, the UCP2 Ins allele and UCP3-55T/T genotype were associated with increased BMI in Asians [REM WMD 0.46, 95% CI 0.09, 0.83 and Fixed Effect Model (FEM) WMD 1.63, 95% CI 0.25, 3.01]. However, a decreased BMI mean was observed for the UCP2-866 A allele in Europeans under a dominant model of inheritance (REM WMD 20.18, 95% CI 20.35, 20.01). There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences. Conclusions: The meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3- 55C/T polymorphisms and BMI mean differences. |
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Brondani, Letícia de AlmeidaAssmann, Taís SilveiraSouza, Bianca Marmontel deBouças, Ana PaulaCanani, Luis Henrique SantosCrispim, Daisy2015-03-04T01:57:58Z20141932-6203http://hdl.handle.net/10183/111612000945893Background: The relationship between uncoupling protein (UCP) 1–3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. However, the impact of these polymorphisms on obesity is still under debate, with contradictory results being reported. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability. Thus, this paper describe a meta-analysis conducted to evaluate if the -3826A/G (UCP1); - 866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3) polymorphisms are associated with BMI changes. Methods: A literature search was run to identify all studies that investigated associations between UCP1-3 polymorphisms and BMI. Weighted mean differences (WMD) were calculated for different inheritance models. Results: Fifty-six studies were eligible for inclusion in the meta-analysis. Meta-analysis results showed that UCP2 55Val/Val genotype was associated with increased BMI in Europeans [Random Effect Model (REM) WMD 0.81, 95% CI 0.20, 1.41]. Moreover, the UCP2 Ins allele and UCP3-55T/T genotype were associated with increased BMI in Asians [REM WMD 0.46, 95% CI 0.09, 0.83 and Fixed Effect Model (FEM) WMD 1.63, 95% CI 0.25, 3.01]. However, a decreased BMI mean was observed for the UCP2-866 A allele in Europeans under a dominant model of inheritance (REM WMD 20.18, 95% CI 20.35, 20.01). There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences. Conclusions: The meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3- 55C/T polymorphisms and BMI mean differences.application/pdfengPLoS ONE. San Francisco. Vol. 9, no. 5 (May 2014), e96411, 10 p.Polimorfismo genéticoObesidadeMetanáliseÍndice de massa corporalMeta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variabilityEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000945893.pdf000945893.pdfTexto completo (inglês)application/pdf743055http://www.lume.ufrgs.br/bitstream/10183/111612/1/000945893.pdf9b08e56634967579989d76e82452f51bMD51TEXT000945893.pdf.txt000945893.pdf.txtExtracted Texttext/plain52730http://www.lume.ufrgs.br/bitstream/10183/111612/2/000945893.pdf.txtdc7c5eaa38aaa5f2c0435ffcdb587e0dMD52THUMBNAIL000945893.pdf.jpg000945893.pdf.jpgGenerated Thumbnailimage/jpeg2258http://www.lume.ufrgs.br/bitstream/10183/111612/3/000945893.pdf.jpg04f73efa93ee0897e36d52c78988c0c0MD5310183/1116122018-10-24 08:48:02.668oai:www.lume.ufrgs.br:10183/111612Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-24T11:48:02Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
title |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
spellingShingle |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability Brondani, Letícia de Almeida Polimorfismo genético Obesidade Metanálise Índice de massa corporal |
title_short |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
title_full |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
title_fullStr |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
title_full_unstemmed |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
title_sort |
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability |
author |
Brondani, Letícia de Almeida |
author_facet |
Brondani, Letícia de Almeida Assmann, Taís Silveira Souza, Bianca Marmontel de Bouças, Ana Paula Canani, Luis Henrique Santos Crispim, Daisy |
author_role |
author |
author2 |
Assmann, Taís Silveira Souza, Bianca Marmontel de Bouças, Ana Paula Canani, Luis Henrique Santos Crispim, Daisy |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Brondani, Letícia de Almeida Assmann, Taís Silveira Souza, Bianca Marmontel de Bouças, Ana Paula Canani, Luis Henrique Santos Crispim, Daisy |
dc.subject.por.fl_str_mv |
Polimorfismo genético Obesidade Metanálise Índice de massa corporal |
topic |
Polimorfismo genético Obesidade Metanálise Índice de massa corporal |
description |
Background: The relationship between uncoupling protein (UCP) 1–3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. However, the impact of these polymorphisms on obesity is still under debate, with contradictory results being reported. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability. Thus, this paper describe a meta-analysis conducted to evaluate if the -3826A/G (UCP1); - 866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3) polymorphisms are associated with BMI changes. Methods: A literature search was run to identify all studies that investigated associations between UCP1-3 polymorphisms and BMI. Weighted mean differences (WMD) were calculated for different inheritance models. Results: Fifty-six studies were eligible for inclusion in the meta-analysis. Meta-analysis results showed that UCP2 55Val/Val genotype was associated with increased BMI in Europeans [Random Effect Model (REM) WMD 0.81, 95% CI 0.20, 1.41]. Moreover, the UCP2 Ins allele and UCP3-55T/T genotype were associated with increased BMI in Asians [REM WMD 0.46, 95% CI 0.09, 0.83 and Fixed Effect Model (FEM) WMD 1.63, 95% CI 0.25, 3.01]. However, a decreased BMI mean was observed for the UCP2-866 A allele in Europeans under a dominant model of inheritance (REM WMD 20.18, 95% CI 20.35, 20.01). There was no significant association of the UCP1-3826A/G polymorphism with BMI mean differences. Conclusions: The meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3- 55C/T polymorphisms and BMI mean differences. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
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2015-03-04T01:57:58Z |
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Estrangeiro info:eu-repo/semantics/article |
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article |
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dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/111612 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
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000945893 |
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http://hdl.handle.net/10183/111612 |
dc.language.iso.fl_str_mv |
eng |
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dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 9, no. 5 (May 2014), e96411, 10 p. |
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