Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21214 |
Resumo: | The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. The aim of the present study was to investigate the levels of S100B in patients in different phases of NC evolution. Cerebrospinal fluid and serum S100B concentrations were measured in 25 patients with NC: 14 patients with degenerative cysts (D), 8 patients with viable cysts (V) and 3 patients with inactive cysts. All NC patients, except 1, had five or less cysts. In most of them, symptoms had been present for at least 1 month before sample collection. Samples from 8 normal controls (C) were also assayed. The albumin quotient was used to estimate the blood-brain barrier permeability. There were no significant differences in serum (P = 0.5) or cerebrospinal fluid (P = 0.91) S100B levels among the V, D, and C groups. These findings suggest that parenchymal changes associated with a relatively small number of degenerating cysts probably have a negligible impact on glial tissue. |
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Lima, José Eduardo de PaulaWalz, RogerTort, Adriano Bretanha LopesSouza, Diogo Onofre Gomes dePortela, Luis Valmor CruzBianchin, Marino MuxfeldtTakayanagui, Osvaldo MassaitiLeite, João Pereira2010-04-24T04:15:46Z20060100-879Xhttp://hdl.handle.net/10183/21214000625970The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. The aim of the present study was to investigate the levels of S100B in patients in different phases of NC evolution. Cerebrospinal fluid and serum S100B concentrations were measured in 25 patients with NC: 14 patients with degenerative cysts (D), 8 patients with viable cysts (V) and 3 patients with inactive cysts. All NC patients, except 1, had five or less cysts. In most of them, symptoms had been present for at least 1 month before sample collection. Samples from 8 normal controls (C) were also assayed. The albumin quotient was used to estimate the blood-brain barrier permeability. There were no significant differences in serum (P = 0.5) or cerebrospinal fluid (P = 0.91) S100B levels among the V, D, and C groups. These findings suggest that parenchymal changes associated with a relatively small number of degenerating cysts probably have a negligible impact on glial tissue.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 39, no. 1 (Jan. 2006), p. 129-135Proteínas S100NeurocisticercoseNeurocysticercosisS100BCerebrospinal fluidAlbumin quotientGlial markerSerum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000625970.pdf000625970.pdfTexto completo (inglês)application/pdf484612http://www.lume.ufrgs.br/bitstream/10183/21214/1/000625970.pdf0c4d2b495b7bf0ec77ca07ff4a8ae5feMD51TEXT000625970.pdf.txt000625970.pdf.txtExtracted Texttext/plain28042http://www.lume.ufrgs.br/bitstream/10183/21214/2/000625970.pdf.txt40d27d449b77149fae4b44c5d576ae30MD52THUMBNAIL000625970.pdf.jpg000625970.pdf.jpgGenerated Thumbnailimage/jpeg1896http://www.lume.ufrgs.br/bitstream/10183/21214/3/000625970.pdf.jpg879bf84b5b603861fb3fe439dc72eb31MD5310183/212142021-11-20 05:55:46.194627oai:www.lume.ufrgs.br:10183/21214Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:55:46Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
title |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
spellingShingle |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis Lima, José Eduardo de Paula Proteínas S100 Neurocisticercose Neurocysticercosis S100B Cerebrospinal fluid Albumin quotient Glial marker |
title_short |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
title_full |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
title_fullStr |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
title_full_unstemmed |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
title_sort |
Serum and cerebrospinal fluid S100B concentrations in patients with neurocysticercosis |
author |
Lima, José Eduardo de Paula |
author_facet |
Lima, José Eduardo de Paula Walz, Roger Tort, Adriano Bretanha Lopes Souza, Diogo Onofre Gomes de Portela, Luis Valmor Cruz Bianchin, Marino Muxfeldt Takayanagui, Osvaldo Massaiti Leite, João Pereira |
author_role |
author |
author2 |
Walz, Roger Tort, Adriano Bretanha Lopes Souza, Diogo Onofre Gomes de Portela, Luis Valmor Cruz Bianchin, Marino Muxfeldt Takayanagui, Osvaldo Massaiti Leite, João Pereira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lima, José Eduardo de Paula Walz, Roger Tort, Adriano Bretanha Lopes Souza, Diogo Onofre Gomes de Portela, Luis Valmor Cruz Bianchin, Marino Muxfeldt Takayanagui, Osvaldo Massaiti Leite, João Pereira |
dc.subject.por.fl_str_mv |
Proteínas S100 Neurocisticercose |
topic |
Proteínas S100 Neurocisticercose Neurocysticercosis S100B Cerebrospinal fluid Albumin quotient Glial marker |
dc.subject.eng.fl_str_mv |
Neurocysticercosis S100B Cerebrospinal fluid Albumin quotient Glial marker |
description |
The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. The aim of the present study was to investigate the levels of S100B in patients in different phases of NC evolution. Cerebrospinal fluid and serum S100B concentrations were measured in 25 patients with NC: 14 patients with degenerative cysts (D), 8 patients with viable cysts (V) and 3 patients with inactive cysts. All NC patients, except 1, had five or less cysts. In most of them, symptoms had been present for at least 1 month before sample collection. Samples from 8 normal controls (C) were also assayed. The albumin quotient was used to estimate the blood-brain barrier permeability. There were no significant differences in serum (P = 0.5) or cerebrospinal fluid (P = 0.91) S100B levels among the V, D, and C groups. These findings suggest that parenchymal changes associated with a relatively small number of degenerating cysts probably have a negligible impact on glial tissue. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006 |
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2010-04-24T04:15:46Z |
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http://hdl.handle.net/10183/21214 |
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0100-879X |
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000625970 |
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http://hdl.handle.net/10183/21214 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 39, no. 1 (Jan. 2006), p. 129-135 |
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