Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/89700 |
Resumo: | Context: Vitamin D insufficiency is associated with increased cardiovascular events in the general population. Additionally, low serum 25-hydroxyvitamin D [25(OH)D] is associated with endothelial dysfunction and arterial stiffness. However, little is known about the association between serum 25(OH)D level and myocardial blood flow. Objective: Our objective was to examine the association between serum 25(OH)D levels and coronary flow reserve (CFR) measured by N-positron emission tomography in asymptomatic middle-aged male twins. Design: The Emory Twin Study is a cross-sectional study of soldiers from the Vietnam Era Registry. Setting: The study was conducted at the General Clinical Research Center, Emory University, Atlanta, GA. Participants: A total of 368 middle-aged male twins were enrolled for the study. Serum 25(OH)D levels were measured in all subjects and classified as vitamin D insufficiency [25(OH)D <30 ng/ml] or sufficiency [25(OH)D ≥30 ng/ml]. Positron emission tomography with [ N]ammonia was used to evaluate myocardial blood flow at rest and after adenosine stress. CFR was measured as the ratio of maximum to rest myocardial blood flow. Main Outcome Measure: Primary outcome was CFR measurement. Results: Mean overall serum 25(OH)D concentration was 37.0 ± 21.4 ng/ml; 167 twins (45%) were vitamin D insufficient. CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season. An abnormal CFR (CFR <2) was more prevalent in subjects with vitamin D insufficiency than with vitamin D sufficiency (31 vs. 20%; P = 0.03). In addition, in vitamin D status-discordant twin pairs, CFR was significantly lower in the vitamin D-insufficient twin than in the vitamin D-sufficient co-twin (2.35 vs. 2.58; P = 0.037). Conclusion: Vitamin D insufficiency is associated with lower CFR in men. This association may help explain some of the increased cardiovascular risk reported in individuals with vitamin D insufficiency. |
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Karohl, CristinaVaccarino, ViolaVeledar, EmirGoldberg, JackTangpricha, VinBellasi, AntonioRaggi, Paolo2014-03-26T01:51:07Z20130021-972Xhttp://hdl.handle.net/10183/89700000909651Context: Vitamin D insufficiency is associated with increased cardiovascular events in the general population. Additionally, low serum 25-hydroxyvitamin D [25(OH)D] is associated with endothelial dysfunction and arterial stiffness. However, little is known about the association between serum 25(OH)D level and myocardial blood flow. Objective: Our objective was to examine the association between serum 25(OH)D levels and coronary flow reserve (CFR) measured by N-positron emission tomography in asymptomatic middle-aged male twins. Design: The Emory Twin Study is a cross-sectional study of soldiers from the Vietnam Era Registry. Setting: The study was conducted at the General Clinical Research Center, Emory University, Atlanta, GA. Participants: A total of 368 middle-aged male twins were enrolled for the study. Serum 25(OH)D levels were measured in all subjects and classified as vitamin D insufficiency [25(OH)D <30 ng/ml] or sufficiency [25(OH)D ≥30 ng/ml]. Positron emission tomography with [ N]ammonia was used to evaluate myocardial blood flow at rest and after adenosine stress. CFR was measured as the ratio of maximum to rest myocardial blood flow. Main Outcome Measure: Primary outcome was CFR measurement. Results: Mean overall serum 25(OH)D concentration was 37.0 ± 21.4 ng/ml; 167 twins (45%) were vitamin D insufficient. CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season. An abnormal CFR (CFR <2) was more prevalent in subjects with vitamin D insufficiency than with vitamin D sufficiency (31 vs. 20%; P = 0.03). In addition, in vitamin D status-discordant twin pairs, CFR was significantly lower in the vitamin D-insufficient twin than in the vitamin D-sufficient co-twin (2.35 vs. 2.58; P = 0.037). Conclusion: Vitamin D insufficiency is associated with lower CFR in men. This association may help explain some of the increased cardiovascular risk reported in individuals with vitamin D insufficiency.application/pdfengThe Journal of clinical endocrinology & metabolism. Vol. 98, no. 1 (Jan 2013), p. 389–397CalcimiméticosCardiomiopatiasDoenças cardiovascularesProgressão da doençaVitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000909651.pdf000909651.pdfTexto completo (inglês)application/pdf145688http://www.lume.ufrgs.br/bitstream/10183/89700/1/000909651.pdf51d340d82f076c0b313752a8891ba3d3MD51TEXT000909651.pdf.txt000909651.pdf.txtExtracted Texttext/plain49867http://www.lume.ufrgs.br/bitstream/10183/89700/2/000909651.pdf.txt1c4b923e96e579f328954b8bcd3d8d97MD52THUMBNAIL000909651.pdf.jpg000909651.pdf.jpgGenerated Thumbnailimage/jpeg2021http://www.lume.ufrgs.br/bitstream/10183/89700/3/000909651.pdf.jpg36e97acc1652b4856ef62c57925ce649MD5310183/897002020-11-08 05:06:54.071539oai:www.lume.ufrgs.br:10183/89700Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-11-08T07:06:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
title |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
spellingShingle |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study Karohl, Cristina Calcimiméticos Cardiomiopatias Doenças cardiovasculares Progressão da doença |
title_short |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
title_full |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
title_fullStr |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
title_full_unstemmed |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
title_sort |
Vitamin D status and coronary flow reserve measured by positron emission tomography : a co-twin control study |
author |
Karohl, Cristina |
author_facet |
Karohl, Cristina Vaccarino, Viola Veledar, Emir Goldberg, Jack Tangpricha, Vin Bellasi, Antonio Raggi, Paolo |
author_role |
author |
author2 |
Vaccarino, Viola Veledar, Emir Goldberg, Jack Tangpricha, Vin Bellasi, Antonio Raggi, Paolo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Karohl, Cristina Vaccarino, Viola Veledar, Emir Goldberg, Jack Tangpricha, Vin Bellasi, Antonio Raggi, Paolo |
dc.subject.por.fl_str_mv |
Calcimiméticos Cardiomiopatias Doenças cardiovasculares Progressão da doença |
topic |
Calcimiméticos Cardiomiopatias Doenças cardiovasculares Progressão da doença |
description |
Context: Vitamin D insufficiency is associated with increased cardiovascular events in the general population. Additionally, low serum 25-hydroxyvitamin D [25(OH)D] is associated with endothelial dysfunction and arterial stiffness. However, little is known about the association between serum 25(OH)D level and myocardial blood flow. Objective: Our objective was to examine the association between serum 25(OH)D levels and coronary flow reserve (CFR) measured by N-positron emission tomography in asymptomatic middle-aged male twins. Design: The Emory Twin Study is a cross-sectional study of soldiers from the Vietnam Era Registry. Setting: The study was conducted at the General Clinical Research Center, Emory University, Atlanta, GA. Participants: A total of 368 middle-aged male twins were enrolled for the study. Serum 25(OH)D levels were measured in all subjects and classified as vitamin D insufficiency [25(OH)D <30 ng/ml] or sufficiency [25(OH)D ≥30 ng/ml]. Positron emission tomography with [ N]ammonia was used to evaluate myocardial blood flow at rest and after adenosine stress. CFR was measured as the ratio of maximum to rest myocardial blood flow. Main Outcome Measure: Primary outcome was CFR measurement. Results: Mean overall serum 25(OH)D concentration was 37.0 ± 21.4 ng/ml; 167 twins (45%) were vitamin D insufficient. CFR was significantly lower in subjects with vitamin D insufficiency compared with subjects with vitamin D sufficiency (2.41 vs. 2.64; P = 0.007), even after adjustment for traditional cardiovascular risk factors, serum PTH, calcium, and phosphorus levels, and season. An abnormal CFR (CFR <2) was more prevalent in subjects with vitamin D insufficiency than with vitamin D sufficiency (31 vs. 20%; P = 0.03). In addition, in vitamin D status-discordant twin pairs, CFR was significantly lower in the vitamin D-insufficient twin than in the vitamin D-sufficient co-twin (2.35 vs. 2.58; P = 0.037). Conclusion: Vitamin D insufficiency is associated with lower CFR in men. This association may help explain some of the increased cardiovascular risk reported in individuals with vitamin D insufficiency. |
publishDate |
2013 |
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2014-03-26T01:51:07Z |
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000909651 |
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The Journal of clinical endocrinology & metabolism. Vol. 98, no. 1 (Jan 2013), p. 389–397 |
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