Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice

Detalhes bibliográficos
Autor(a) principal: Loreto, Érico Silva
Data de Publicação: 2019
Outros Autores: Tondolo, Juliana Simoni Moraes, Jesus, Francielli Pantella Kunz de, Verdi, Camila Marina, Weiblen, Carla, Azevedo, Maria Isabel de, Kommers, Glaucia Denise, Santúrio, Jânio Morais, Zanette, Regis Adriel, Alves, Sydney Hartz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/188815
Resumo: We evaluated the efficacy of azithromycin (50 mg/kg, every 12 h [q12h] orally) and miltefosine (25 mg/kg, q24h orally) treatments in an experimental model of vascular/disseminated pythiosis in immunosuppressed mice. Azithromycin was the only treatment able to reduce mortality. The histopathological findings showed acute vascular inflammation, pathogen dissemination, necrotizing myositis, neuritis, and arteritis. The results suggest that azithromycin, but not miltefosine, may have clinical relevance in the treatment of vascular/disseminated pythiosis.
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spelling Loreto, Érico SilvaTondolo, Juliana Simoni MoraesJesus, Francielli Pantella Kunz deVerdi, Camila MarinaWeiblen, CarlaAzevedo, Maria Isabel deKommers, Glaucia DeniseSantúrio, Jânio MoraisZanette, Regis AdrielAlves, Sydney Hartz2019-02-15T02:33:50Z20190066-4804http://hdl.handle.net/10183/188815001084932We evaluated the efficacy of azithromycin (50 mg/kg, every 12 h [q12h] orally) and miltefosine (25 mg/kg, q24h orally) treatments in an experimental model of vascular/disseminated pythiosis in immunosuppressed mice. Azithromycin was the only treatment able to reduce mortality. The histopathological findings showed acute vascular inflammation, pathogen dissemination, necrotizing myositis, neuritis, and arteritis. The results suggest that azithromycin, but not miltefosine, may have clinical relevance in the treatment of vascular/disseminated pythiosis.application/pdfengAntimicrobial agents and chemotherapy. Washington. Vol. 63, no. 1 (Jan. 2019), e01385-18, 7 p.AzitromicinaAntifúngicosPitiosePythium insidiosumAzithromycinMiltefosineTreatmentEfficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed miceEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001084932.pdf.txt001084932.pdf.txtExtracted Texttext/plain26203http://www.lume.ufrgs.br/bitstream/10183/188815/2/001084932.pdf.txt5618f2579decec5e298ef6d8d3a344abMD52ORIGINAL001084932.pdfTexto completo (inglês)application/pdf557284http://www.lume.ufrgs.br/bitstream/10183/188815/1/001084932.pdf13e0f93aab606acd2dc5a638719b1847MD5110183/1888152019-02-16 02:34:31.639259oai:www.lume.ufrgs.br:10183/188815Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2019-02-16T04:34:31Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
title Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
spellingShingle Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
Loreto, Érico Silva
Azitromicina
Antifúngicos
Pitiose
Pythium insidiosum
Azithromycin
Miltefosine
Treatment
title_short Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
title_full Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
title_fullStr Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
title_full_unstemmed Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
title_sort Efficacy of azithromycin and miltefosine in experimental systemic pythiosis in immunosuppressed mice
author Loreto, Érico Silva
author_facet Loreto, Érico Silva
Tondolo, Juliana Simoni Moraes
Jesus, Francielli Pantella Kunz de
Verdi, Camila Marina
Weiblen, Carla
Azevedo, Maria Isabel de
Kommers, Glaucia Denise
Santúrio, Jânio Morais
Zanette, Regis Adriel
Alves, Sydney Hartz
author_role author
author2 Tondolo, Juliana Simoni Moraes
Jesus, Francielli Pantella Kunz de
Verdi, Camila Marina
Weiblen, Carla
Azevedo, Maria Isabel de
Kommers, Glaucia Denise
Santúrio, Jânio Morais
Zanette, Regis Adriel
Alves, Sydney Hartz
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Loreto, Érico Silva
Tondolo, Juliana Simoni Moraes
Jesus, Francielli Pantella Kunz de
Verdi, Camila Marina
Weiblen, Carla
Azevedo, Maria Isabel de
Kommers, Glaucia Denise
Santúrio, Jânio Morais
Zanette, Regis Adriel
Alves, Sydney Hartz
dc.subject.por.fl_str_mv Azitromicina
Antifúngicos
Pitiose
topic Azitromicina
Antifúngicos
Pitiose
Pythium insidiosum
Azithromycin
Miltefosine
Treatment
dc.subject.eng.fl_str_mv Pythium insidiosum
Azithromycin
Miltefosine
Treatment
description We evaluated the efficacy of azithromycin (50 mg/kg, every 12 h [q12h] orally) and miltefosine (25 mg/kg, q24h orally) treatments in an experimental model of vascular/disseminated pythiosis in immunosuppressed mice. Azithromycin was the only treatment able to reduce mortality. The histopathological findings showed acute vascular inflammation, pathogen dissemination, necrotizing myositis, neuritis, and arteritis. The results suggest that azithromycin, but not miltefosine, may have clinical relevance in the treatment of vascular/disseminated pythiosis.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-02-15T02:33:50Z
dc.date.issued.fl_str_mv 2019
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/188815
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.nrb.pt_BR.fl_str_mv 001084932
identifier_str_mv 0066-4804
001084932
url http://hdl.handle.net/10183/188815
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Antimicrobial agents and chemotherapy. Washington. Vol. 63, no. 1 (Jan. 2019), e01385-18, 7 p.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
instname:Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
instname_str Universidade Federal do Rio Grande do Sul (UFRGS)
instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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