Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview

Detalhes bibliográficos
Autor(a) principal: Loreto, Érico Silva
Data de Publicação: 2024
Outros Autores: Tondolo, Juliana Simoni Moraes, Zanette, Regis Adriel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/280164
Resumo: This review article explores the effectiveness of antibacterial drugs that inhibit protein synthesis in treating pythiosis, a difficult-to-treat infection caused by Pythium insidiosum. The article highlights the susceptibility of P. insidiosum to antibacterial drugs, such as macrolides, oxazolidinones, and tetracyclines. We examine various studies, including in vitro tests, experimental infection models, and clinical case reports. Based on our synthesis of these findings, we highlight the potential of these drugs in managing pythiosis, primarily when combined with surgical interventions. The review emphasizes the need for personalized treatment strategies and further research to establish standardized testing protocols and optimize therapeutic approaches.
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spelling Loreto, Érico SilvaTondolo, Juliana Simoni MoraesZanette, Regis Adriel2024-10-18T06:57:04Z20242309-608Xhttp://hdl.handle.net/10183/280164001200429This review article explores the effectiveness of antibacterial drugs that inhibit protein synthesis in treating pythiosis, a difficult-to-treat infection caused by Pythium insidiosum. The article highlights the susceptibility of P. insidiosum to antibacterial drugs, such as macrolides, oxazolidinones, and tetracyclines. We examine various studies, including in vitro tests, experimental infection models, and clinical case reports. Based on our synthesis of these findings, we highlight the potential of these drugs in managing pythiosis, primarily when combined with surgical interventions. The review emphasizes the need for personalized treatment strategies and further research to establish standardized testing protocols and optimize therapeutic approaches.application/pdfengJournal of fungi. Basel. Vol. 10, no. 4 (Apr. 2024), 234, 21 p.AntifúngicosPitioseLinezolidaAzitromicinaPythium insidiosumPythiosis treatmentProtein-inhibiting antibacterialsAzithromycinLinezolidTreating pythiosis with antibacterial drugs targeting protein synthesis : an overviewEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001200429.pdf.txt001200429.pdf.txtExtracted Texttext/plain83943http://www.lume.ufrgs.br/bitstream/10183/280164/2/001200429.pdf.txt0b98fa76851edd4032a91919ad158bd4MD52ORIGINAL001200429.pdfTexto completo (inglês)application/pdf3432464http://www.lume.ufrgs.br/bitstream/10183/280164/1/001200429.pdfb2463f3504d68634c816691622f2713fMD5110183/2801642024-10-19 06:18:28.027906oai:www.lume.ufrgs.br:10183/280164Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2024-10-19T09:18:28Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
title Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
spellingShingle Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
Loreto, Érico Silva
Antifúngicos
Pitiose
Linezolida
Azitromicina
Pythium insidiosum
Pythiosis treatment
Protein-inhibiting antibacterials
Azithromycin
Linezolid
title_short Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
title_full Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
title_fullStr Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
title_full_unstemmed Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
title_sort Treating pythiosis with antibacterial drugs targeting protein synthesis : an overview
author Loreto, Érico Silva
author_facet Loreto, Érico Silva
Tondolo, Juliana Simoni Moraes
Zanette, Regis Adriel
author_role author
author2 Tondolo, Juliana Simoni Moraes
Zanette, Regis Adriel
author2_role author
author
dc.contributor.author.fl_str_mv Loreto, Érico Silva
Tondolo, Juliana Simoni Moraes
Zanette, Regis Adriel
dc.subject.por.fl_str_mv Antifúngicos
Pitiose
Linezolida
Azitromicina
topic Antifúngicos
Pitiose
Linezolida
Azitromicina
Pythium insidiosum
Pythiosis treatment
Protein-inhibiting antibacterials
Azithromycin
Linezolid
dc.subject.eng.fl_str_mv Pythium insidiosum
Pythiosis treatment
Protein-inhibiting antibacterials
Azithromycin
Linezolid
description This review article explores the effectiveness of antibacterial drugs that inhibit protein synthesis in treating pythiosis, a difficult-to-treat infection caused by Pythium insidiosum. The article highlights the susceptibility of P. insidiosum to antibacterial drugs, such as macrolides, oxazolidinones, and tetracyclines. We examine various studies, including in vitro tests, experimental infection models, and clinical case reports. Based on our synthesis of these findings, we highlight the potential of these drugs in managing pythiosis, primarily when combined with surgical interventions. The review emphasizes the need for personalized treatment strategies and further research to establish standardized testing protocols and optimize therapeutic approaches.
publishDate 2024
dc.date.accessioned.fl_str_mv 2024-10-18T06:57:04Z
dc.date.issued.fl_str_mv 2024
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.issn.pt_BR.fl_str_mv 2309-608X
dc.identifier.nrb.pt_BR.fl_str_mv 001200429
identifier_str_mv 2309-608X
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url http://hdl.handle.net/10183/280164
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Journal of fungi. Basel. Vol. 10, no. 4 (Apr. 2024), 234, 21 p.
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instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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