Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/267281 |
Resumo: | Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive/stereotyped behaviors. Its prevalence is increasing, affecting one in 36 children in the United States. The valproic acid (VPA) induced animal model of ASD is a reliable method for investigating cellular, molecular, and behavioral aspects related to the disorder. Trans-Resveratrol (RSV), a polyphenol with anti-inflammatory and antioxidant effects studied in various diseases, has recently demonstrated the ability to prevent cellular, molecular, sensory, and social deficits in the VPA model. In this study, we examined the effects of prenatal exposure to VPA and the potential preventive effects of RSV on the offspring. Method: We monitored gestational weight from embryonic day 6.5 until 18.5 and assessed the onset of developmental milestones and morphometric parameters in litters. The generalized estimating equations (GEE) were used to analyze longitudinal data. Results: Exposure to VPA during rat pregnancy resulted in abnormal weight gain fold-changes on embryonic days 13.5 and 18.5, followed by fewer animals per litter. Additionally, we discovered a positive correlation between weight variation during E15.5-E18.5 and the number of rat pups in the VPA group. Conclusion: VPA exposure led to slight length deficiencies and delays in the onset of developmental milestones. Interestingly, the prenatal RSV treatment not only prevented most of these delays but also led to the early onset of certain milestones and improved morphometric characteristics in the offspring. In summary, our findings suggest that RSV may have potential as a therapeutic intervention to protect against the negative effects of prenatal VPA exposure, highlighting its importance in future studies of prenatal neurodevelopmental disorders. |
id |
UFRGS-2_20af888e63306c52812a925a1ba524cb |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/267281 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Schwingel, Gustavo BrumSilva, Mellanie Fontes Dutra daRamos, Bárbara SantosRiesgo, Rudimar dos SantosBambini Júnior, VictorioGottfried, Carmem Juracy Silveira2023-11-18T03:26:52Z20232667-2421http://hdl.handle.net/10183/267281001187784Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive/stereotyped behaviors. Its prevalence is increasing, affecting one in 36 children in the United States. The valproic acid (VPA) induced animal model of ASD is a reliable method for investigating cellular, molecular, and behavioral aspects related to the disorder. Trans-Resveratrol (RSV), a polyphenol with anti-inflammatory and antioxidant effects studied in various diseases, has recently demonstrated the ability to prevent cellular, molecular, sensory, and social deficits in the VPA model. In this study, we examined the effects of prenatal exposure to VPA and the potential preventive effects of RSV on the offspring. Method: We monitored gestational weight from embryonic day 6.5 until 18.5 and assessed the onset of developmental milestones and morphometric parameters in litters. The generalized estimating equations (GEE) were used to analyze longitudinal data. Results: Exposure to VPA during rat pregnancy resulted in abnormal weight gain fold-changes on embryonic days 13.5 and 18.5, followed by fewer animals per litter. Additionally, we discovered a positive correlation between weight variation during E15.5-E18.5 and the number of rat pups in the VPA group. Conclusion: VPA exposure led to slight length deficiencies and delays in the onset of developmental milestones. Interestingly, the prenatal RSV treatment not only prevented most of these delays but also led to the early onset of certain milestones and improved morphometric characteristics in the offspring. In summary, our findings suggest that RSV may have potential as a therapeutic intervention to protect against the negative effects of prenatal VPA exposure, highlighting its importance in future studies of prenatal neurodevelopmental disorders.application/pdfengIBRO neuroscience reports. [Amsterdam]. Vol. 15 (Dec. 2023), p. 242-251Transtornos do neurodesenvolvimentoTranstorno do espectro autistaResveratrolÁcido valpróicoAutismVPAMilestonesAnimal modelMorphometric parametersRodentRatPreventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acidEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001187784.pdf.txt001187784.pdf.txtExtracted Texttext/plain59660http://www.lume.ufrgs.br/bitstream/10183/267281/2/001187784.pdf.txtc0ac0e958f65920cfed7a7d821a5dd53MD52ORIGINAL001187784.pdfTexto completo (inglês)application/pdf5618564http://www.lume.ufrgs.br/bitstream/10183/267281/1/001187784.pdf1304550ab4cb25014a6e215c37e04686MD5110183/2672812023-12-14 04:24:41.262485oai:www.lume.ufrgs.br:10183/267281Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-12-14T06:24:41Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
title |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
spellingShingle |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid Schwingel, Gustavo Brum Transtornos do neurodesenvolvimento Transtorno do espectro autista Resveratrol Ácido valpróico Autism VPA Milestones Animal model Morphometric parameters Rodent Rat |
title_short |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
title_full |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
title_fullStr |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
title_full_unstemmed |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
title_sort |
Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid |
author |
Schwingel, Gustavo Brum |
author_facet |
Schwingel, Gustavo Brum Silva, Mellanie Fontes Dutra da Ramos, Bárbara Santos Riesgo, Rudimar dos Santos Bambini Júnior, Victorio Gottfried, Carmem Juracy Silveira |
author_role |
author |
author2 |
Silva, Mellanie Fontes Dutra da Ramos, Bárbara Santos Riesgo, Rudimar dos Santos Bambini Júnior, Victorio Gottfried, Carmem Juracy Silveira |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Schwingel, Gustavo Brum Silva, Mellanie Fontes Dutra da Ramos, Bárbara Santos Riesgo, Rudimar dos Santos Bambini Júnior, Victorio Gottfried, Carmem Juracy Silveira |
dc.subject.por.fl_str_mv |
Transtornos do neurodesenvolvimento Transtorno do espectro autista Resveratrol Ácido valpróico |
topic |
Transtornos do neurodesenvolvimento Transtorno do espectro autista Resveratrol Ácido valpróico Autism VPA Milestones Animal model Morphometric parameters Rodent Rat |
dc.subject.eng.fl_str_mv |
Autism VPA Milestones Animal model Morphometric parameters Rodent Rat |
description |
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by social interaction deficits and repetitive/stereotyped behaviors. Its prevalence is increasing, affecting one in 36 children in the United States. The valproic acid (VPA) induced animal model of ASD is a reliable method for investigating cellular, molecular, and behavioral aspects related to the disorder. Trans-Resveratrol (RSV), a polyphenol with anti-inflammatory and antioxidant effects studied in various diseases, has recently demonstrated the ability to prevent cellular, molecular, sensory, and social deficits in the VPA model. In this study, we examined the effects of prenatal exposure to VPA and the potential preventive effects of RSV on the offspring. Method: We monitored gestational weight from embryonic day 6.5 until 18.5 and assessed the onset of developmental milestones and morphometric parameters in litters. The generalized estimating equations (GEE) were used to analyze longitudinal data. Results: Exposure to VPA during rat pregnancy resulted in abnormal weight gain fold-changes on embryonic days 13.5 and 18.5, followed by fewer animals per litter. Additionally, we discovered a positive correlation between weight variation during E15.5-E18.5 and the number of rat pups in the VPA group. Conclusion: VPA exposure led to slight length deficiencies and delays in the onset of developmental milestones. Interestingly, the prenatal RSV treatment not only prevented most of these delays but also led to the early onset of certain milestones and improved morphometric characteristics in the offspring. In summary, our findings suggest that RSV may have potential as a therapeutic intervention to protect against the negative effects of prenatal VPA exposure, highlighting its importance in future studies of prenatal neurodevelopmental disorders. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-11-18T03:26:52Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/267281 |
dc.identifier.issn.pt_BR.fl_str_mv |
2667-2421 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001187784 |
identifier_str_mv |
2667-2421 001187784 |
url |
http://hdl.handle.net/10183/267281 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
IBRO neuroscience reports. [Amsterdam]. Vol. 15 (Dec. 2023), p. 242-251 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/267281/2/001187784.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/267281/1/001187784.pdf |
bitstream.checksum.fl_str_mv |
c0ac0e958f65920cfed7a7d821a5dd53 1304550ab4cb25014a6e215c37e04686 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801225104629170176 |