Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results

Detalhes bibliográficos
Autor(a) principal: Battel, Lucas Ferreira
Data de Publicação: 2020
Outros Autores: Swartz, Johnna, Anés, Maurício, Manfro, Pedro Henrique Gaiva, Rohde, Luis Augusto Paim, Andrade, Anna Carolina Viduani Martinez de, Mondelli, Valeria, Kieling, Christian Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/206678
Resumo: Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.
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spelling Battel, Lucas FerreiraSwartz, JohnnaAnés, MaurícioManfro, Pedro Henrique GaivaRohde, Luis Augusto PaimAndrade, Anna Carolina Viduani Martinez deMondelli, ValeriaKieling, Christian Costa2020-03-12T04:13:24Z20201516-4446http://hdl.handle.net/10183/206678001113325Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.application/pdfengRevista brasileira de psiquiatria. São Paulo. Vol. 42, n. 1 (jan./fev. 2020), p. 6-13Imagem por ressonância magnéticaDepressãoProtocolos clínicosAdolescenteDepressionAdolescentNeuroimagingNeuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary resultsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001113325.pdf.txt001113325.pdf.txtExtracted Texttext/plain43014http://www.lume.ufrgs.br/bitstream/10183/206678/2/001113325.pdf.txtbe2f9492f576764c9a8d112b3bd3faa1MD52ORIGINAL001113325.pdfTexto completo (inglês)application/pdf365073http://www.lume.ufrgs.br/bitstream/10183/206678/1/001113325.pdfb6ad6b9c46e13365e713fa85fd8772b1MD5110183/2066782023-08-16 03:30:39.760343oai:www.lume.ufrgs.br:10183/206678Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-16T06:30:39Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
title Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
spellingShingle Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
Battel, Lucas Ferreira
Imagem por ressonância magnética
Depressão
Protocolos clínicos
Adolescente
Depression
Adolescent
Neuroimaging
title_short Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
title_full Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
title_fullStr Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
title_full_unstemmed Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
title_sort Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
author Battel, Lucas Ferreira
author_facet Battel, Lucas Ferreira
Swartz, Johnna
Anés, Maurício
Manfro, Pedro Henrique Gaiva
Rohde, Luis Augusto Paim
Andrade, Anna Carolina Viduani Martinez de
Mondelli, Valeria
Kieling, Christian Costa
author_role author
author2 Swartz, Johnna
Anés, Maurício
Manfro, Pedro Henrique Gaiva
Rohde, Luis Augusto Paim
Andrade, Anna Carolina Viduani Martinez de
Mondelli, Valeria
Kieling, Christian Costa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Battel, Lucas Ferreira
Swartz, Johnna
Anés, Maurício
Manfro, Pedro Henrique Gaiva
Rohde, Luis Augusto Paim
Andrade, Anna Carolina Viduani Martinez de
Mondelli, Valeria
Kieling, Christian Costa
dc.subject.por.fl_str_mv Imagem por ressonância magnética
Depressão
Protocolos clínicos
Adolescente
topic Imagem por ressonância magnética
Depressão
Protocolos clínicos
Adolescente
Depression
Adolescent
Neuroimaging
dc.subject.eng.fl_str_mv Depression
Adolescent
Neuroimaging
description Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.
publishDate 2020
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dc.relation.ispartof.pt_BR.fl_str_mv Revista brasileira de psiquiatria. São Paulo. Vol. 42, n. 1 (jan./fev. 2020), p. 6-13
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