Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/206678 |
Resumo: | Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. |
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Battel, Lucas FerreiraSwartz, JohnnaAnés, MaurícioManfro, Pedro Henrique GaivaRohde, Luis Augusto PaimAndrade, Anna Carolina Viduani Martinez deMondelli, ValeriaKieling, Christian Costa2020-03-12T04:13:24Z20201516-4446http://hdl.handle.net/10183/206678001113325Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.application/pdfengRevista brasileira de psiquiatria. São Paulo. Vol. 42, n. 1 (jan./fev. 2020), p. 6-13Imagem por ressonância magnéticaDepressãoProtocolos clínicosAdolescenteDepressionAdolescentNeuroimagingNeuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary resultsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001113325.pdf.txt001113325.pdf.txtExtracted Texttext/plain43014http://www.lume.ufrgs.br/bitstream/10183/206678/2/001113325.pdf.txtbe2f9492f576764c9a8d112b3bd3faa1MD52ORIGINAL001113325.pdfTexto completo (inglês)application/pdf365073http://www.lume.ufrgs.br/bitstream/10183/206678/1/001113325.pdfb6ad6b9c46e13365e713fa85fd8772b1MD5110183/2066782023-08-16 03:30:39.760343oai:www.lume.ufrgs.br:10183/206678Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-16T06:30:39Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
title |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
spellingShingle |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results Battel, Lucas Ferreira Imagem por ressonância magnética Depressão Protocolos clínicos Adolescente Depression Adolescent Neuroimaging |
title_short |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
title_full |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
title_fullStr |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
title_full_unstemmed |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
title_sort |
Neuroimaging adolescents with depression in a middle-income country : feasibility of an fMRI protocol and preliminary results |
author |
Battel, Lucas Ferreira |
author_facet |
Battel, Lucas Ferreira Swartz, Johnna Anés, Maurício Manfro, Pedro Henrique Gaiva Rohde, Luis Augusto Paim Andrade, Anna Carolina Viduani Martinez de Mondelli, Valeria Kieling, Christian Costa |
author_role |
author |
author2 |
Swartz, Johnna Anés, Maurício Manfro, Pedro Henrique Gaiva Rohde, Luis Augusto Paim Andrade, Anna Carolina Viduani Martinez de Mondelli, Valeria Kieling, Christian Costa |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Battel, Lucas Ferreira Swartz, Johnna Anés, Maurício Manfro, Pedro Henrique Gaiva Rohde, Luis Augusto Paim Andrade, Anna Carolina Viduani Martinez de Mondelli, Valeria Kieling, Christian Costa |
dc.subject.por.fl_str_mv |
Imagem por ressonância magnética Depressão Protocolos clínicos Adolescente |
topic |
Imagem por ressonância magnética Depressão Protocolos clínicos Adolescente Depression Adolescent Neuroimaging |
dc.subject.eng.fl_str_mv |
Depression Adolescent Neuroimaging |
description |
Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-03-12T04:13:24Z |
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2020 |
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001113325 |
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Revista brasileira de psiquiatria. São Paulo. Vol. 42, n. 1 (jan./fev. 2020), p. 6-13 |
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