DNA methylation in adolescents with anxiety disorder : a longitudinal study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/206702 |
Resumo: | Anxiety disorders (AD) typically manifest in children and adolescents and might persist into adulthood. However, there are still few data concerning epigenetic mechanisms associated with onset, persistence or remission of AD over time. We investigated a cohort of adolescents and young adults at baseline (age; 13.19±2.38) and after 5 years and classifed them according to the AD diagnosis and their longitudinal trajectories into 4 groups: (1) Typically Developing Comparisons (TDC; control group, n=14); (2) Incident (AD in the second evaluation only, n=11); (3) Persistent (AD in both evaluations, n=14) and (4) Remittent (AD in the frst evaluation only, n=8). DNA methylation was evaluated with the Infnium HumanMethylation450 BeadChip from saliva samples collected at both evaluations. Gene set enrichment analysis was applied to consider biological pathways. We found decreased DNA methylation in TDC group while the chronic cases of AD presented hypermethylation in central nervous system development pathways. Moreover, we showed that this persistent group also presented hypermethylation while the other three groups were associated with hypomethylation in nervous system development pathway. Incidence and remission groups were associated with increased and decreased methylation in neuron development pathways, respectively. Larger studies are likely to detect specifc genes relevant to AD. |
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Bortoluzzi, AndressaSalum Junior, Giovanni AbrahãoRosa, Eduarda Dias daChagas, Vinicius de SaraivaCastro, Mauro Antônio AlvesManfro, Gisele Gus2020-03-12T04:14:00Z20182045-2322http://hdl.handle.net/10183/206702001112652Anxiety disorders (AD) typically manifest in children and adolescents and might persist into adulthood. However, there are still few data concerning epigenetic mechanisms associated with onset, persistence or remission of AD over time. We investigated a cohort of adolescents and young adults at baseline (age; 13.19±2.38) and after 5 years and classifed them according to the AD diagnosis and their longitudinal trajectories into 4 groups: (1) Typically Developing Comparisons (TDC; control group, n=14); (2) Incident (AD in the second evaluation only, n=11); (3) Persistent (AD in both evaluations, n=14) and (4) Remittent (AD in the frst evaluation only, n=8). DNA methylation was evaluated with the Infnium HumanMethylation450 BeadChip from saliva samples collected at both evaluations. Gene set enrichment analysis was applied to consider biological pathways. We found decreased DNA methylation in TDC group while the chronic cases of AD presented hypermethylation in central nervous system development pathways. Moreover, we showed that this persistent group also presented hypermethylation while the other three groups were associated with hypomethylation in nervous system development pathway. Incidence and remission groups were associated with increased and decreased methylation in neuron development pathways, respectively. Larger studies are likely to detect specifc genes relevant to AD.application/pdfengScientific reports. London. Vol.8 (2018), 13800, 12 p.Estudos longitudinaisMetilação de DNATranstornos de ansiedadeAdolescenteDNA methylation in adolescents with anxiety disorder : a longitudinal studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001112652.pdf.txt001112652.pdf.txtExtracted Texttext/plain55479http://www.lume.ufrgs.br/bitstream/10183/206702/2/001112652.pdf.txt81e8df6aa54da44c808d64a8a74e32c8MD52ORIGINAL001112652.pdfTexto completo (inglês)application/pdf1509767http://www.lume.ufrgs.br/bitstream/10183/206702/1/001112652.pdf8e05ee55a7f519b765bee04a24286832MD5110183/2067022020-03-13 04:16:39.016488oai:www.lume.ufrgs.br:10183/206702Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2020-03-13T07:16:39Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
title |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
spellingShingle |
DNA methylation in adolescents with anxiety disorder : a longitudinal study Bortoluzzi, Andressa Estudos longitudinais Metilação de DNA Transtornos de ansiedade Adolescente |
title_short |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
title_full |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
title_fullStr |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
title_full_unstemmed |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
title_sort |
DNA methylation in adolescents with anxiety disorder : a longitudinal study |
author |
Bortoluzzi, Andressa |
author_facet |
Bortoluzzi, Andressa Salum Junior, Giovanni Abrahão Rosa, Eduarda Dias da Chagas, Vinicius de Saraiva Castro, Mauro Antônio Alves Manfro, Gisele Gus |
author_role |
author |
author2 |
Salum Junior, Giovanni Abrahão Rosa, Eduarda Dias da Chagas, Vinicius de Saraiva Castro, Mauro Antônio Alves Manfro, Gisele Gus |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Bortoluzzi, Andressa Salum Junior, Giovanni Abrahão Rosa, Eduarda Dias da Chagas, Vinicius de Saraiva Castro, Mauro Antônio Alves Manfro, Gisele Gus |
dc.subject.por.fl_str_mv |
Estudos longitudinais Metilação de DNA Transtornos de ansiedade Adolescente |
topic |
Estudos longitudinais Metilação de DNA Transtornos de ansiedade Adolescente |
description |
Anxiety disorders (AD) typically manifest in children and adolescents and might persist into adulthood. However, there are still few data concerning epigenetic mechanisms associated with onset, persistence or remission of AD over time. We investigated a cohort of adolescents and young adults at baseline (age; 13.19±2.38) and after 5 years and classifed them according to the AD diagnosis and their longitudinal trajectories into 4 groups: (1) Typically Developing Comparisons (TDC; control group, n=14); (2) Incident (AD in the second evaluation only, n=11); (3) Persistent (AD in both evaluations, n=14) and (4) Remittent (AD in the frst evaluation only, n=8). DNA methylation was evaluated with the Infnium HumanMethylation450 BeadChip from saliva samples collected at both evaluations. Gene set enrichment analysis was applied to consider biological pathways. We found decreased DNA methylation in TDC group while the chronic cases of AD presented hypermethylation in central nervous system development pathways. Moreover, we showed that this persistent group also presented hypermethylation while the other three groups were associated with hypomethylation in nervous system development pathway. Incidence and remission groups were associated with increased and decreased methylation in neuron development pathways, respectively. Larger studies are likely to detect specifc genes relevant to AD. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-03-12T04:14:00Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/206702 |
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2045-2322 |
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001112652 |
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2045-2322 001112652 |
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http://hdl.handle.net/10183/206702 |
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eng |
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Scientific reports. London. Vol.8 (2018), 13800, 12 p. |
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openAccess |
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