Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

Detalhes bibliográficos
Autor(a) principal: Baumont, Angélica Cerveira de
Data de Publicação: 2021
Outros Autores: Hoffmann, Maurício Scopel, Bortoluzzi, Andressa, Fries, Gabriel Rodrigo, Lavandoski, Patricia, Grun, Lucas Kich, Guimarães, Luciano Santos Pinto, Guma, Fátima Theresinha Costa Rodrigues, Salum Junior, Giovanni Abrahão, Barbé-Tuana, Florencia María, Manfro, Gisele Gus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/221802
Resumo: Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.
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spelling Baumont, Angélica Cerveira deHoffmann, Maurício ScopelBortoluzzi, AndressaFries, Gabriel RodrigoLavandoski, PatriciaGrun, Lucas KichGuimarães, Luciano Santos PintoGuma, Fátima Theresinha Costa RodriguesSalum Junior, Giovanni AbrahãoBarbé-Tuana, Florencia MaríaManfro, Gisele Gus2021-06-02T04:33:11Z20212045-2322http://hdl.handle.net/10183/221802001125886Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.application/pdfengScientific reports. London. Vol. 11 (2021), 7716, 9 p.Transtornos de ansiedadeAdolescenteHomeostase do telômeroBiomarcadoresFatores etáriosDNATelomere length and epigenetic age acceleration in adolescents with anxiety disordersEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001125886.pdf.txt001125886.pdf.txtExtracted Texttext/plain50453http://www.lume.ufrgs.br/bitstream/10183/221802/2/001125886.pdf.txta530e538589772a43ad54f1bafd8e9c8MD52ORIGINAL001125886.pdfTexto completo (inglês)application/pdf1540096http://www.lume.ufrgs.br/bitstream/10183/221802/1/001125886.pdf48da9c32d17924554b562b042cd70e47MD5110183/2218022021-06-13 04:29:41.891618oai:www.lume.ufrgs.br:10183/221802Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-06-13T07:29:41Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
title Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
spellingShingle Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
Baumont, Angélica Cerveira de
Transtornos de ansiedade
Adolescente
Homeostase do telômero
Biomarcadores
Fatores etários
DNA
title_short Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
title_full Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
title_fullStr Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
title_full_unstemmed Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
title_sort Telomere length and epigenetic age acceleration in adolescents with anxiety disorders
author Baumont, Angélica Cerveira de
author_facet Baumont, Angélica Cerveira de
Hoffmann, Maurício Scopel
Bortoluzzi, Andressa
Fries, Gabriel Rodrigo
Lavandoski, Patricia
Grun, Lucas Kich
Guimarães, Luciano Santos Pinto
Guma, Fátima Theresinha Costa Rodrigues
Salum Junior, Giovanni Abrahão
Barbé-Tuana, Florencia María
Manfro, Gisele Gus
author_role author
author2 Hoffmann, Maurício Scopel
Bortoluzzi, Andressa
Fries, Gabriel Rodrigo
Lavandoski, Patricia
Grun, Lucas Kich
Guimarães, Luciano Santos Pinto
Guma, Fátima Theresinha Costa Rodrigues
Salum Junior, Giovanni Abrahão
Barbé-Tuana, Florencia María
Manfro, Gisele Gus
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Baumont, Angélica Cerveira de
Hoffmann, Maurício Scopel
Bortoluzzi, Andressa
Fries, Gabriel Rodrigo
Lavandoski, Patricia
Grun, Lucas Kich
Guimarães, Luciano Santos Pinto
Guma, Fátima Theresinha Costa Rodrigues
Salum Junior, Giovanni Abrahão
Barbé-Tuana, Florencia María
Manfro, Gisele Gus
dc.subject.por.fl_str_mv Transtornos de ansiedade
Adolescente
Homeostase do telômero
Biomarcadores
Fatores etários
DNA
topic Transtornos de ansiedade
Adolescente
Homeostase do telômero
Biomarcadores
Fatores etários
DNA
description Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-02T04:33:11Z
dc.date.issued.fl_str_mv 2021
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dc.relation.ispartof.pt_BR.fl_str_mv Scientific reports. London. Vol. 11 (2021), 7716, 9 p.
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dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRGS
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