ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/266244 |
Resumo: | The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to identify variations and contribute to the understanding of evolutionary dynamics behind this successful adaptation to infect humans. Our results reveal that 4% of the ACE2 sites are under positive selection, all located in the catalytic domain, suggesting possibly taxon-specific adaptations related to the ACE2 function, such as cardiovascular physiology. Considering all variable sites, we selected 30 of them located at the critical ACE2 binding sites to the SARS-CoV-like viruses for analysis in more detail. Our results reveal a relatively high diversity of ACE2 between placental mammal species, while showing no polymorphism within human populations, at least considering the 30 inter-species variable sites. A perfect scenario for natural selection favored this opportunistic new coronavirus in its trajectory of infecting humans. We suggest that SARS-CoV-2 became a specialist coronavirus for human hosts. Differences in the rate of infection and mortality could be related to the innate immune responses, other unknown genetic factors, as well as non-biological factors. |
id |
UFRGS-2_2d11d29d7c6b9546ee2bc396122e6503 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/266244 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Fam, Bibiana Sampaio de OliveiraVargas Pinilla, PedroAmorim, Carlos Eduardo GuerraSortica, Vinicius de AlbuquerqueBortolini, Maria Cátira2023-10-26T03:38:51Z20201415-4757http://hdl.handle.net/10183/266244001152867The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to identify variations and contribute to the understanding of evolutionary dynamics behind this successful adaptation to infect humans. Our results reveal that 4% of the ACE2 sites are under positive selection, all located in the catalytic domain, suggesting possibly taxon-specific adaptations related to the ACE2 function, such as cardiovascular physiology. Considering all variable sites, we selected 30 of them located at the critical ACE2 binding sites to the SARS-CoV-like viruses for analysis in more detail. Our results reveal a relatively high diversity of ACE2 between placental mammal species, while showing no polymorphism within human populations, at least considering the 30 inter-species variable sites. A perfect scenario for natural selection favored this opportunistic new coronavirus in its trajectory of infecting humans. We suggest that SARS-CoV-2 became a specialist coronavirus for human hosts. Differences in the rate of infection and mortality could be related to the innate immune responses, other unknown genetic factors, as well as non-biological factors.application/pdfengGenetics and molecular biology. Ribeirão Preto. Vol. 43, n.2 (2020), e20200104, 10 p.COVID-19Diversidade genéticaACE2Placental mammalsSARS-CoV-2Inter and intra-species diversityACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2info:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001152867.pdf.txt001152867.pdf.txtExtracted Texttext/plain54732http://www.lume.ufrgs.br/bitstream/10183/266244/2/001152867.pdf.txtaf41f37aa7be6495cd2fc585d62b9b35MD52ORIGINAL001152867.pdfTexto completo (inglês)application/pdf3031228http://www.lume.ufrgs.br/bitstream/10183/266244/1/001152867.pdf053c7b07edf33fd3df2c9efb5fecd7e1MD5110183/2662442023-10-27 03:27:53.124381oai:www.lume.ufrgs.br:10183/266244Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-27T06:27:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
title |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
spellingShingle |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 Fam, Bibiana Sampaio de Oliveira COVID-19 Diversidade genética ACE2 Placental mammals SARS-CoV-2 Inter and intra-species diversity |
title_short |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
title_full |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
title_fullStr |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
title_full_unstemmed |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
title_sort |
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2 |
author |
Fam, Bibiana Sampaio de Oliveira |
author_facet |
Fam, Bibiana Sampaio de Oliveira Vargas Pinilla, Pedro Amorim, Carlos Eduardo Guerra Sortica, Vinicius de Albuquerque Bortolini, Maria Cátira |
author_role |
author |
author2 |
Vargas Pinilla, Pedro Amorim, Carlos Eduardo Guerra Sortica, Vinicius de Albuquerque Bortolini, Maria Cátira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Fam, Bibiana Sampaio de Oliveira Vargas Pinilla, Pedro Amorim, Carlos Eduardo Guerra Sortica, Vinicius de Albuquerque Bortolini, Maria Cátira |
dc.subject.por.fl_str_mv |
COVID-19 Diversidade genética |
topic |
COVID-19 Diversidade genética ACE2 Placental mammals SARS-CoV-2 Inter and intra-species diversity |
dc.subject.eng.fl_str_mv |
ACE2 Placental mammals SARS-CoV-2 Inter and intra-species diversity |
description |
The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to identify variations and contribute to the understanding of evolutionary dynamics behind this successful adaptation to infect humans. Our results reveal that 4% of the ACE2 sites are under positive selection, all located in the catalytic domain, suggesting possibly taxon-specific adaptations related to the ACE2 function, such as cardiovascular physiology. Considering all variable sites, we selected 30 of them located at the critical ACE2 binding sites to the SARS-CoV-like viruses for analysis in more detail. Our results reveal a relatively high diversity of ACE2 between placental mammal species, while showing no polymorphism within human populations, at least considering the 30 inter-species variable sites. A perfect scenario for natural selection favored this opportunistic new coronavirus in its trajectory of infecting humans. We suggest that SARS-CoV-2 became a specialist coronavirus for human hosts. Differences in the rate of infection and mortality could be related to the innate immune responses, other unknown genetic factors, as well as non-biological factors. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2023-10-26T03:38:51Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/266244 |
dc.identifier.issn.pt_BR.fl_str_mv |
1415-4757 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001152867 |
identifier_str_mv |
1415-4757 001152867 |
url |
http://hdl.handle.net/10183/266244 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto. Vol. 43, n.2 (2020), e20200104, 10 p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/266244/2/001152867.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/266244/1/001152867.pdf |
bitstream.checksum.fl_str_mv |
af41f37aa7be6495cd2fc585d62b9b35 053c7b07edf33fd3df2c9efb5fecd7e1 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801225101617659904 |