Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/232031 |
Resumo: | For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS. |
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Londero, Marina Dalla BarbaSousa, Mathias Hasse dePerin, Carolina PetryCzepielewski, Letícia SanguinettiClaudino, Felipe Cesar de AlmeidaGama, Clarissa Severino2021-11-19T04:46:34Z20212357-9730http://hdl.handle.net/10183/232031001132484For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 41, n. 2 (2021), p. 167-169EsquizofreniaHospitalização psiquiatricaClozapinaSchizophreniaTreatment-resistantClozapineHospitalizationClozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophreniainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001132484.pdf.txt001132484.pdf.txtExtracted Texttext/plain11415http://www.lume.ufrgs.br/bitstream/10183/232031/2/001132484.pdf.txt206095129354a1474c7fd9dfaca617c4MD52ORIGINAL001132484.pdfTexto completo (inglês)application/pdf223388http://www.lume.ufrgs.br/bitstream/10183/232031/1/001132484.pdf92856fcf96cbf4d1f8831c74891803adMD5110183/2320312023-11-05 04:24:54.168734oai:www.lume.ufrgs.br:10183/232031Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-05T06:24:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
title |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
spellingShingle |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia Londero, Marina Dalla Barba Esquizofrenia Hospitalização psiquiatrica Clozapina Schizophrenia Treatment-resistant Clozapine Hospitalization |
title_short |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
title_full |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
title_fullStr |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
title_full_unstemmed |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
title_sort |
Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia |
author |
Londero, Marina Dalla Barba |
author_facet |
Londero, Marina Dalla Barba Sousa, Mathias Hasse de Perin, Carolina Petry Czepielewski, Letícia Sanguinetti Claudino, Felipe Cesar de Almeida Gama, Clarissa Severino |
author_role |
author |
author2 |
Sousa, Mathias Hasse de Perin, Carolina Petry Czepielewski, Letícia Sanguinetti Claudino, Felipe Cesar de Almeida Gama, Clarissa Severino |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Londero, Marina Dalla Barba Sousa, Mathias Hasse de Perin, Carolina Petry Czepielewski, Letícia Sanguinetti Claudino, Felipe Cesar de Almeida Gama, Clarissa Severino |
dc.subject.por.fl_str_mv |
Esquizofrenia Hospitalização psiquiatrica Clozapina |
topic |
Esquizofrenia Hospitalização psiquiatrica Clozapina Schizophrenia Treatment-resistant Clozapine Hospitalization |
dc.subject.eng.fl_str_mv |
Schizophrenia Treatment-resistant Clozapine Hospitalization |
description |
For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-11-19T04:46:34Z |
dc.date.issued.fl_str_mv |
2021 |
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001132484 |
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dc.relation.ispartof.pt_BR.fl_str_mv |
Clinical and biomedical research. Porto Alegre. Vol. 41, n. 2 (2021), p. 167-169 |
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