Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia

Detalhes bibliográficos
Autor(a) principal: Londero, Marina Dalla Barba
Data de Publicação: 2021
Outros Autores: Sousa, Mathias Hasse de, Perin, Carolina Petry, Czepielewski, Letícia Sanguinetti, Claudino, Felipe Cesar de Almeida, Gama, Clarissa Severino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/232031
Resumo: For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.
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spelling Londero, Marina Dalla BarbaSousa, Mathias Hasse dePerin, Carolina PetryCzepielewski, Letícia SanguinettiClaudino, Felipe Cesar de AlmeidaGama, Clarissa Severino2021-11-19T04:46:34Z20212357-9730http://hdl.handle.net/10183/232031001132484For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.application/pdfengClinical and biomedical research. Porto Alegre. Vol. 41, n. 2 (2021), p. 167-169EsquizofreniaHospitalização psiquiatricaClozapinaSchizophreniaTreatment-resistantClozapineHospitalizationClozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophreniainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001132484.pdf.txt001132484.pdf.txtExtracted Texttext/plain11415http://www.lume.ufrgs.br/bitstream/10183/232031/2/001132484.pdf.txt206095129354a1474c7fd9dfaca617c4MD52ORIGINAL001132484.pdfTexto completo (inglês)application/pdf223388http://www.lume.ufrgs.br/bitstream/10183/232031/1/001132484.pdf92856fcf96cbf4d1f8831c74891803adMD5110183/2320312023-11-05 04:24:54.168734oai:www.lume.ufrgs.br:10183/232031Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-05T06:24:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
title Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
spellingShingle Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
Londero, Marina Dalla Barba
Esquizofrenia
Hospitalização psiquiatrica
Clozapina
Schizophrenia
Treatment-resistant
Clozapine
Hospitalization
title_short Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
title_full Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
title_fullStr Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
title_full_unstemmed Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
title_sort Clozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophrenia
author Londero, Marina Dalla Barba
author_facet Londero, Marina Dalla Barba
Sousa, Mathias Hasse de
Perin, Carolina Petry
Czepielewski, Letícia Sanguinetti
Claudino, Felipe Cesar de Almeida
Gama, Clarissa Severino
author_role author
author2 Sousa, Mathias Hasse de
Perin, Carolina Petry
Czepielewski, Letícia Sanguinetti
Claudino, Felipe Cesar de Almeida
Gama, Clarissa Severino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Londero, Marina Dalla Barba
Sousa, Mathias Hasse de
Perin, Carolina Petry
Czepielewski, Letícia Sanguinetti
Claudino, Felipe Cesar de Almeida
Gama, Clarissa Severino
dc.subject.por.fl_str_mv Esquizofrenia
Hospitalização psiquiatrica
Clozapina
topic Esquizofrenia
Hospitalização psiquiatrica
Clozapina
Schizophrenia
Treatment-resistant
Clozapine
Hospitalization
dc.subject.eng.fl_str_mv Schizophrenia
Treatment-resistant
Clozapine
Hospitalization
description For years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-19T04:46:34Z
dc.date.issued.fl_str_mv 2021
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dc.relation.ispartof.pt_BR.fl_str_mv Clinical and biomedical research. Porto Alegre. Vol. 41, n. 2 (2021), p. 167-169
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