Ionic liquid-loaded microcapsules doped into dental resin infiltrants

• Autor(a) principal: Cuppini, Marla
• Data de Publicação: 2021
• Outros Autores: Garcia, Isadora Martini, Souza, Virgínia Serra de, Zatta, Kelly Cristine, Visioli, Fernanda, Leitune, Vicente Castelo Branco, Guterres, Silvia Stanisçuaski, Scholten, Jackson Damiani, Collares, Fabrício Mezzomo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRGS
• Texto Completo: http://hdl.handle.net/10183/242567
• topic: Propriedades de superfície; Cárie dentária; Sistemas de liberação de medicamentos; Polímeros; Surface properties; Dental caries; Drug delivery systems; Polymers

Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, we developed a novel resin infiltrant with microcapsules loaded with an ionic liquid (MC-IL), and analyzed the physical properties and cytotoxicity of the dental resin. First, the ionic liquid 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMI.NTf2) was synthesized. BMI.NTf2 has previously shown antibacterial activity in a dental resin. Then, MC-IL were synthesized by the deposition of a preformed polymer. The MC-IL were analyzed for particle size and de-agglomeration effect via laser diffraction analysis and shape via scan ning electron microscopy (SEM). The infiltrants were formulated, and the MC-IL were incorporated at 2.5%, 5%, and 10 wt%. A group without MC-IL was used as a control. The infiltrants were evaluated for ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity. The MC-IL showed a mean particle size of 1.64 (±0.08) μm, shriveled aspect, and a de-agglomeration profile suggestive of nanoparticles’ presence in the synthesized powder. There were no differences in UTS among groups (p > 0.05). The incorporation of 10 wt% of MC-IL increased the contact angle (p < 0.05), while the addition from 5 wt% reduced the SFE in comparison to the control group (p < 0.05). The human cell viability was above 90% for all groups (p > 0.05). The incorpo ration of microcapsules as a drug-delivery system for ionic liquids may be a promising strategy to improve dental restorative materials.