Ionic liquid-loaded microcapsules doped into dental resin infiltrants
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/242567 |
Resumo: | Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, we developed a novel resin infiltrant with microcapsules loaded with an ionic liquid (MC-IL), and analyzed the physical properties and cytotoxicity of the dental resin. First, the ionic liquid 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMI.NTf2) was synthesized. BMI.NTf2 has previously shown antibacterial activity in a dental resin. Then, MC-IL were synthesized by the deposition of a preformed polymer. The MC-IL were analyzed for particle size and de-agglomeration effect via laser diffraction analysis and shape via scan ning electron microscopy (SEM). The infiltrants were formulated, and the MC-IL were incorporated at 2.5%, 5%, and 10 wt%. A group without MC-IL was used as a control. The infiltrants were evaluated for ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity. The MC-IL showed a mean particle size of 1.64 (±0.08) μm, shriveled aspect, and a de-agglomeration profile suggestive of nanoparticles’ presence in the synthesized powder. There were no differences in UTS among groups (p > 0.05). The incorporation of 10 wt% of MC-IL increased the contact angle (p < 0.05), while the addition from 5 wt% reduced the SFE in comparison to the control group (p < 0.05). The human cell viability was above 90% for all groups (p > 0.05). The incorpo ration of microcapsules as a drug-delivery system for ionic liquids may be a promising strategy to improve dental restorative materials. |
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Cuppini, MarlaGarcia, Isadora MartiniSouza, Virgínia Serra deZatta, Kelly CristineVisioli, FernandaLeitune, Vicente Castelo BrancoGuterres, Silvia StanisçuaskiScholten, Jackson DamianiCollares, Fabrício Mezzomo2022-07-15T04:48:29Z20212452-199Xhttp://hdl.handle.net/10183/242567001142005Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, we developed a novel resin infiltrant with microcapsules loaded with an ionic liquid (MC-IL), and analyzed the physical properties and cytotoxicity of the dental resin. First, the ionic liquid 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMI.NTf2) was synthesized. BMI.NTf2 has previously shown antibacterial activity in a dental resin. Then, MC-IL were synthesized by the deposition of a preformed polymer. The MC-IL were analyzed for particle size and de-agglomeration effect via laser diffraction analysis and shape via scan ning electron microscopy (SEM). The infiltrants were formulated, and the MC-IL were incorporated at 2.5%, 5%, and 10 wt%. A group without MC-IL was used as a control. The infiltrants were evaluated for ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity. The MC-IL showed a mean particle size of 1.64 (±0.08) μm, shriveled aspect, and a de-agglomeration profile suggestive of nanoparticles’ presence in the synthesized powder. There were no differences in UTS among groups (p > 0.05). The incorporation of 10 wt% of MC-IL increased the contact angle (p < 0.05), while the addition from 5 wt% reduced the SFE in comparison to the control group (p < 0.05). The human cell viability was above 90% for all groups (p > 0.05). The incorpo ration of microcapsules as a drug-delivery system for ionic liquids may be a promising strategy to improve dental restorative materials.application/pdfengBioactive materials. Beijing. Vol. 6, no. 9 (2021), p.2667-2675Propriedades de superfícieCárie dentáriaSistemas de liberação de medicamentosPolímerosSurface propertiesDental cariesDrug delivery systemsPolymersIonic liquid-loaded microcapsules doped into dental resin infiltrantsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001142005.pdf.txt001142005.pdf.txtExtracted Texttext/plain50999http://www.lume.ufrgs.br/bitstream/10183/242567/2/001142005.pdf.txt3ecc959e0160eafd8c7d2f5fc59e17d8MD52ORIGINAL001142005.pdfTexto completo (inglês)application/pdf4072431http://www.lume.ufrgs.br/bitstream/10183/242567/1/001142005.pdf0ad2b360693aa7868337c512b7cd9063MD5110183/2425672022-07-16 05:04:53.648469oai:www.lume.ufrgs.br:10183/242567Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-07-16T08:04:53Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
title |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
spellingShingle |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants Cuppini, Marla Propriedades de superfície Cárie dentária Sistemas de liberação de medicamentos Polímeros Surface properties Dental caries Drug delivery systems Polymers |
title_short |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
title_full |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
title_fullStr |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
title_full_unstemmed |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
title_sort |
Ionic liquid-loaded microcapsules doped into dental resin infiltrants |
author |
Cuppini, Marla |
author_facet |
Cuppini, Marla Garcia, Isadora Martini Souza, Virgínia Serra de Zatta, Kelly Cristine Visioli, Fernanda Leitune, Vicente Castelo Branco Guterres, Silvia Stanisçuaski Scholten, Jackson Damiani Collares, Fabrício Mezzomo |
author_role |
author |
author2 |
Garcia, Isadora Martini Souza, Virgínia Serra de Zatta, Kelly Cristine Visioli, Fernanda Leitune, Vicente Castelo Branco Guterres, Silvia Stanisçuaski Scholten, Jackson Damiani Collares, Fabrício Mezzomo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cuppini, Marla Garcia, Isadora Martini Souza, Virgínia Serra de Zatta, Kelly Cristine Visioli, Fernanda Leitune, Vicente Castelo Branco Guterres, Silvia Stanisçuaski Scholten, Jackson Damiani Collares, Fabrício Mezzomo |
dc.subject.por.fl_str_mv |
Propriedades de superfície Cárie dentária Sistemas de liberação de medicamentos Polímeros |
topic |
Propriedades de superfície Cárie dentária Sistemas de liberação de medicamentos Polímeros Surface properties Dental caries Drug delivery systems Polymers |
dc.subject.eng.fl_str_mv |
Surface properties Dental caries Drug delivery systems Polymers |
description |
Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, we developed a novel resin infiltrant with microcapsules loaded with an ionic liquid (MC-IL), and analyzed the physical properties and cytotoxicity of the dental resin. First, the ionic liquid 1-n-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMI.NTf2) was synthesized. BMI.NTf2 has previously shown antibacterial activity in a dental resin. Then, MC-IL were synthesized by the deposition of a preformed polymer. The MC-IL were analyzed for particle size and de-agglomeration effect via laser diffraction analysis and shape via scan ning electron microscopy (SEM). The infiltrants were formulated, and the MC-IL were incorporated at 2.5%, 5%, and 10 wt%. A group without MC-IL was used as a control. The infiltrants were evaluated for ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity. The MC-IL showed a mean particle size of 1.64 (±0.08) μm, shriveled aspect, and a de-agglomeration profile suggestive of nanoparticles’ presence in the synthesized powder. There were no differences in UTS among groups (p > 0.05). The incorporation of 10 wt% of MC-IL increased the contact angle (p < 0.05), while the addition from 5 wt% reduced the SFE in comparison to the control group (p < 0.05). The human cell viability was above 90% for all groups (p > 0.05). The incorpo ration of microcapsules as a drug-delivery system for ionic liquids may be a promising strategy to improve dental restorative materials. |
publishDate |
2021 |
dc.date.issued.fl_str_mv |
2021 |
dc.date.accessioned.fl_str_mv |
2022-07-15T04:48:29Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/242567 |
dc.identifier.issn.pt_BR.fl_str_mv |
2452-199X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001142005 |
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2452-199X 001142005 |
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http://hdl.handle.net/10183/242567 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Bioactive materials. Beijing. Vol. 6, no. 9 (2021), p.2667-2675 |
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