Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/131377 |
Resumo: | Tumor cells and structure both evolve due to heritable variation of cell behaviors and selection over periods of weeks to years (somatic evolution). Micro-environmental factors exert selection pressures on tumor-cell behaviors, which influence both the rate and direction of evolution of specific behaviors, especially the development of tumor-cell aggression and resistance to chemotherapies. In this paper, we present, step-by-step, the development of a multi-cell, virtual-tissue model of tumor somatic evolution, simulated using the open-source CompuCell3D modeling environment. Our model includes essential cell behaviors, microenvironmental components and their interactions. Our model provides a platform for exploring selection pressures leading to the evolution of tumor-cell aggression, showing that emergent stratification into regions with different cell survival rates drives the evolution of less cohesive cells with lower levels of cadherins and higher levels of integrins. Such reduced cohesivity is a key hallmark in the progression of many types of solid tumors. |
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Swat, MaciejThomas, Gilberto LimaShirinifard, AbbasClendenon, Sherry G.Glazier, James Alexander2015-12-25T02:39:08Z20151932-6203http://hdl.handle.net/10183/131377000969522Tumor cells and structure both evolve due to heritable variation of cell behaviors and selection over periods of weeks to years (somatic evolution). Micro-environmental factors exert selection pressures on tumor-cell behaviors, which influence both the rate and direction of evolution of specific behaviors, especially the development of tumor-cell aggression and resistance to chemotherapies. In this paper, we present, step-by-step, the development of a multi-cell, virtual-tissue model of tumor somatic evolution, simulated using the open-source CompuCell3D modeling environment. Our model includes essential cell behaviors, microenvironmental components and their interactions. Our model provides a platform for exploring selection pressures leading to the evolution of tumor-cell aggression, showing that emergent stratification into regions with different cell survival rates drives the evolution of less cohesive cells with lower levels of cadherins and higher levels of integrins. Such reduced cohesivity is a key hallmark in the progression of many types of solid tumors.application/pdfengPLoS ONE. San Francisco. Vol. 10, no. 6 (June 2015), e0127972, 40 p.Dinamica celularBiofisica celularSimulação computacionalTensão superficialEmergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3DEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000969522.pdf000969522.pdfTexto completo (inglês)application/pdf12931295http://www.lume.ufrgs.br/bitstream/10183/131377/1/000969522.pdfc12165ee770a19d91f199b6a9630915cMD51TEXT000969522.pdf.txt000969522.pdf.txtExtracted Texttext/plain96056http://www.lume.ufrgs.br/bitstream/10183/131377/2/000969522.pdf.txte638a8257236f2496f7fadc24e682cf9MD52THUMBNAIL000969522.pdf.jpg000969522.pdf.jpgGenerated Thumbnailimage/jpeg2054http://www.lume.ufrgs.br/bitstream/10183/131377/3/000969522.pdf.jpg326f5c12481883ede2afa1a8bca185e0MD5310183/1313772023-08-11 03:54:15.611834oai:www.lume.ufrgs.br:10183/131377Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-08-11T06:54:15Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
title |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
spellingShingle |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D Swat, Maciej Dinamica celular Biofisica celular Simulação computacional Tensão superficial |
title_short |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
title_full |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
title_fullStr |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
title_full_unstemmed |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
title_sort |
Emergent stratification in solid tumors selects for reduced cohesion of tumor cells : a multi-cell, virtual-tissue model of tumor evolution using CompuCell3D |
author |
Swat, Maciej |
author_facet |
Swat, Maciej Thomas, Gilberto Lima Shirinifard, Abbas Clendenon, Sherry G. Glazier, James Alexander |
author_role |
author |
author2 |
Thomas, Gilberto Lima Shirinifard, Abbas Clendenon, Sherry G. Glazier, James Alexander |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Swat, Maciej Thomas, Gilberto Lima Shirinifard, Abbas Clendenon, Sherry G. Glazier, James Alexander |
dc.subject.por.fl_str_mv |
Dinamica celular Biofisica celular Simulação computacional Tensão superficial |
topic |
Dinamica celular Biofisica celular Simulação computacional Tensão superficial |
description |
Tumor cells and structure both evolve due to heritable variation of cell behaviors and selection over periods of weeks to years (somatic evolution). Micro-environmental factors exert selection pressures on tumor-cell behaviors, which influence both the rate and direction of evolution of specific behaviors, especially the development of tumor-cell aggression and resistance to chemotherapies. In this paper, we present, step-by-step, the development of a multi-cell, virtual-tissue model of tumor somatic evolution, simulated using the open-source CompuCell3D modeling environment. Our model includes essential cell behaviors, microenvironmental components and their interactions. Our model provides a platform for exploring selection pressures leading to the evolution of tumor-cell aggression, showing that emergent stratification into regions with different cell survival rates drives the evolution of less cohesive cells with lower levels of cadherins and higher levels of integrins. Such reduced cohesivity is a key hallmark in the progression of many types of solid tumors. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-12-25T02:39:08Z |
dc.date.issued.fl_str_mv |
2015 |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/131377 |
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1932-6203 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000969522 |
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http://hdl.handle.net/10183/131377 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS ONE. San Francisco. Vol. 10, no. 6 (June 2015), e0127972, 40 p. |
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openAccess |
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application/pdf |
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