The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/95162 |
Resumo: | Objectives: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). Methods: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale – Reviewed. The Val66Met polymorphism at the BDNF was genotyped from a blood sample. Patients’ IQ and executive functions were assessed by a standard cognitive flexibility test (WCST). Results: Fifty-three subjects were included in the study. No significant difference was observed between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA (F48,5 = .76; p = .59; Perseverative Errors, p=.66; Nonperseverative Errors, p = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; and Percentage of Conceptual Level Responses, p = .99). Conclusions: Our findings from this sample of children and adolescents with BD do not replicate results from studies of adults and suggest the existence of differences in the neurobiology of this disorder across the life cycle. Investigations of larger samples are necessary to confirm these data. |
id |
UFRGS-2_3cd5fc03cee293c23b8a9bdeb2e6267a |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/95162 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Zeni, Cristian PatrickTramontina, SilzáZeni, Thamis AlineCoelho, Roberta Paula SchellPheula, Gabriel FerreiraBernardi, Julio MocellinMaldaner, UrsulaSilva, Talita LopesOliveira, Angélica Salatino deHutz, Mara HelenaRohde, Luis Augusto Paim2014-05-13T02:03:56Z20131516-4446http://hdl.handle.net/10183/95162000914311Objectives: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). Methods: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale – Reviewed. The Val66Met polymorphism at the BDNF was genotyped from a blood sample. Patients’ IQ and executive functions were assessed by a standard cognitive flexibility test (WCST). Results: Fifty-three subjects were included in the study. No significant difference was observed between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA (F48,5 = .76; p = .59; Perseverative Errors, p=.66; Nonperseverative Errors, p = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; and Percentage of Conceptual Level Responses, p = .99). Conclusions: Our findings from this sample of children and adolescents with BD do not replicate results from studies of adults and suggest the existence of differences in the neurobiology of this disorder across the life cycle. Investigations of larger samples are necessary to confirm these data.application/pdfengRevista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (2013), p. 44-50.Fator neurotrófico derivado do encéfaloTranstorno bipolarCriançaAdolescenteBDNFBipolar disorderChildrenAdolescentsWisconsin card sorting testThe Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorderinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000914311.pdf000914311.pdfTexto completo (inglês)application/pdf372305http://www.lume.ufrgs.br/bitstream/10183/95162/1/000914311.pdf98fab38e98b06930e7d286c4ac7f9a56MD51TEXT000914311.pdf.txt000914311.pdf.txtExtracted Texttext/plain34514http://www.lume.ufrgs.br/bitstream/10183/95162/2/000914311.pdf.txtb1ab37319a89bf8a42004dbfd1edc1c2MD52THUMBNAIL000914311.pdf.jpg000914311.pdf.jpgGenerated Thumbnailimage/jpeg1995http://www.lume.ufrgs.br/bitstream/10183/95162/3/000914311.pdf.jpgb801576644929aa2418edc28f1c5c799MD5310183/951622021-05-07 05:05:46.982253oai:www.lume.ufrgs.br:10183/95162Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-05-07T08:05:46Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
title |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
spellingShingle |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder Zeni, Cristian Patrick Fator neurotrófico derivado do encéfalo Transtorno bipolar Criança Adolescente BDNF Bipolar disorder Children Adolescents Wisconsin card sorting test |
title_short |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
title_full |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
title_fullStr |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
title_full_unstemmed |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
title_sort |
The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card Sorting Test results in children and adolescents with bipolar disorder |
author |
Zeni, Cristian Patrick |
author_facet |
Zeni, Cristian Patrick Tramontina, Silzá Zeni, Thamis Aline Coelho, Roberta Paula Schell Pheula, Gabriel Ferreira Bernardi, Julio Mocellin Maldaner, Ursula Silva, Talita Lopes Oliveira, Angélica Salatino de Hutz, Mara Helena Rohde, Luis Augusto Paim |
author_role |
author |
author2 |
Tramontina, Silzá Zeni, Thamis Aline Coelho, Roberta Paula Schell Pheula, Gabriel Ferreira Bernardi, Julio Mocellin Maldaner, Ursula Silva, Talita Lopes Oliveira, Angélica Salatino de Hutz, Mara Helena Rohde, Luis Augusto Paim |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zeni, Cristian Patrick Tramontina, Silzá Zeni, Thamis Aline Coelho, Roberta Paula Schell Pheula, Gabriel Ferreira Bernardi, Julio Mocellin Maldaner, Ursula Silva, Talita Lopes Oliveira, Angélica Salatino de Hutz, Mara Helena Rohde, Luis Augusto Paim |
dc.subject.por.fl_str_mv |
Fator neurotrófico derivado do encéfalo Transtorno bipolar Criança Adolescente |
topic |
Fator neurotrófico derivado do encéfalo Transtorno bipolar Criança Adolescente BDNF Bipolar disorder Children Adolescents Wisconsin card sorting test |
dc.subject.eng.fl_str_mv |
BDNF Bipolar disorder Children Adolescents Wisconsin card sorting test |
description |
Objectives: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). Methods: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale – Reviewed. The Val66Met polymorphism at the BDNF was genotyped from a blood sample. Patients’ IQ and executive functions were assessed by a standard cognitive flexibility test (WCST). Results: Fifty-three subjects were included in the study. No significant difference was observed between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA (F48,5 = .76; p = .59; Perseverative Errors, p=.66; Nonperseverative Errors, p = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; and Percentage of Conceptual Level Responses, p = .99). Conclusions: Our findings from this sample of children and adolescents with BD do not replicate results from studies of adults and suggest the existence of differences in the neurobiology of this disorder across the life cycle. Investigations of larger samples are necessary to confirm these data. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-05-13T02:03:56Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/95162 |
dc.identifier.issn.pt_BR.fl_str_mv |
1516-4446 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000914311 |
identifier_str_mv |
1516-4446 000914311 |
url |
http://hdl.handle.net/10183/95162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Revista brasileira de psiquiatria (1999). São Paulo. Vol. 35, n. 1 (2013), p. 44-50. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/95162/1/000914311.pdf http://www.lume.ufrgs.br/bitstream/10183/95162/2/000914311.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/95162/3/000914311.pdf.jpg |
bitstream.checksum.fl_str_mv |
98fab38e98b06930e7d286c4ac7f9a56 b1ab37319a89bf8a42004dbfd1edc1c2 b801576644929aa2418edc28f1c5c799 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224833555496960 |