Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/24629 |
Resumo: | We studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European (hpEurope) and all from Koreans were hspEAsia but that Amerindians and Mestizos carried mixed strains: hspAmerind and hpEurope strains had been cultured from Amerindians and hpEurope and hpAfrica1 were cultured from Mestizos. The least genetically diverse H. pylori strains were hspAmerind. Strains hpEurope were the most diverse and showed remarkable multilocus sequence mosaicism (indicating recombination). The lower genetic structure in hpEurope strains is consistent with colonization of a diversity of hosts. If diversity is important for the success of H. pylori, then the low diversity of Amerindian strains might be linked to their apparent tendency to disappear. This suggests that Amerindian strains may lack the needed diversity to survive the diversity brought by non-Amerindian hosts. |
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Dominguez-Bello, Maria G.Pérez, Maria E.Bortolini, Maria CátiraSalzano, Francisco MauroPericchi, Luis R.Zambrano-Guzmán, OrlisbethLinz, Bodo2010-07-15T04:18:12Z20081932-6203http://hdl.handle.net/10183/24629000686524We studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European (hpEurope) and all from Koreans were hspEAsia but that Amerindians and Mestizos carried mixed strains: hspAmerind and hpEurope strains had been cultured from Amerindians and hpEurope and hpAfrica1 were cultured from Mestizos. The least genetically diverse H. pylori strains were hspAmerind. Strains hpEurope were the most diverse and showed remarkable multilocus sequence mosaicism (indicating recombination). The lower genetic structure in hpEurope strains is consistent with colonization of a diversity of hosts. If diversity is important for the success of H. pylori, then the low diversity of Amerindian strains might be linked to their apparent tendency to disappear. This suggests that Amerindian strains may lack the needed diversity to survive the diversity brought by non-Amerindian hosts.application/pdfengPLoS One. San Francisco. Vol. 3, no.10 (oct. 2008), e3307, 7 p.Genética humanaHelicobacter pyloriAmeríndiosAmérica LatinaAmerindian Helicobacter pylori strains go extinct, as european strains expand their host rangeEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000686524.pdf.txt000686524.pdf.txtExtracted Texttext/plain35622http://www.lume.ufrgs.br/bitstream/10183/24629/2/000686524.pdf.txt55fc426d183e2d491a7735b784753ee6MD52ORIGINAL000686524.pdf000686524.pdfTexto completo (inglês)application/pdf262316http://www.lume.ufrgs.br/bitstream/10183/24629/1/000686524.pdf0e1b5638be26a14d3bae1d66f25255e5MD51THUMBNAIL000686524.pdf.jpg000686524.pdf.jpgGenerated Thumbnailimage/jpeg2021http://www.lume.ufrgs.br/bitstream/10183/24629/3/000686524.pdf.jpg99e0222eac8d949a14aff9b24d6a87caMD5310183/246292023-09-23 03:34:44.179853oai:www.lume.ufrgs.br:10183/24629Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-09-23T06:34:44Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
title |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
spellingShingle |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range Dominguez-Bello, Maria G. Genética humana Helicobacter pylori Ameríndios América Latina |
title_short |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
title_full |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
title_fullStr |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
title_full_unstemmed |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
title_sort |
Amerindian Helicobacter pylori strains go extinct, as european strains expand their host range |
author |
Dominguez-Bello, Maria G. |
author_facet |
Dominguez-Bello, Maria G. Pérez, Maria E. Bortolini, Maria Cátira Salzano, Francisco Mauro Pericchi, Luis R. Zambrano-Guzmán, Orlisbeth Linz, Bodo |
author_role |
author |
author2 |
Pérez, Maria E. Bortolini, Maria Cátira Salzano, Francisco Mauro Pericchi, Luis R. Zambrano-Guzmán, Orlisbeth Linz, Bodo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Dominguez-Bello, Maria G. Pérez, Maria E. Bortolini, Maria Cátira Salzano, Francisco Mauro Pericchi, Luis R. Zambrano-Guzmán, Orlisbeth Linz, Bodo |
dc.subject.por.fl_str_mv |
Genética humana Helicobacter pylori Ameríndios América Latina |
topic |
Genética humana Helicobacter pylori Ameríndios América Latina |
description |
We studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European (hpEurope) and all from Koreans were hspEAsia but that Amerindians and Mestizos carried mixed strains: hspAmerind and hpEurope strains had been cultured from Amerindians and hpEurope and hpAfrica1 were cultured from Mestizos. The least genetically diverse H. pylori strains were hspAmerind. Strains hpEurope were the most diverse and showed remarkable multilocus sequence mosaicism (indicating recombination). The lower genetic structure in hpEurope strains is consistent with colonization of a diversity of hosts. If diversity is important for the success of H. pylori, then the low diversity of Amerindian strains might be linked to their apparent tendency to disappear. This suggests that Amerindian strains may lack the needed diversity to survive the diversity brought by non-Amerindian hosts. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2010-07-15T04:18:12Z |
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http://hdl.handle.net/10183/24629 |
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1932-6203 |
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000686524 |
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http://hdl.handle.net/10183/24629 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
PLoS One. San Francisco. Vol. 3, no.10 (oct. 2008), e3307, 7 p. |
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