Shared genetic background between children and adults with attention deficit/hyperactivity disorder

Detalhes bibliográficos
Autor(a) principal: Rovira, Paula
Data de Publicação: 2020
Outros Autores: Grevet, Eugenio Horácio, Hutz, Mara Helena, Rovaris, Diego Luiz, Oliveira, Angélica Salatino de, Silva, Bruna Santos da, Bau, Claiton Henrique Dotto, Rohde, Luis Augusto Paim, Ribasés, Marta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/217931
Resumo: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective
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spelling Rovira, PaulaGrevet, Eugenio HorácioHutz, Mara HelenaRovaris, Diego LuizOliveira, Angélica Salatino deSilva, Bruna Santos daBau, Claiton Henrique DottoRohde, Luis Augusto PaimRibasés, Marta2021-02-12T04:06:00Z20200893-133Xhttp://hdl.handle.net/10183/217931001121246Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspectiveapplication/pdfengNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. London. Vol. 45 (2020), p. 1617–1626Marcadores genéticosTranstorno do déficit de atenção com hiperatividadeCriançaAdultoMetanálisePatrimônio genéticoShared genetic background between children and adults with attention deficit/hyperactivity disorderEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001121246.pdf.txt001121246.pdf.txtExtracted Texttext/plain70749http://www.lume.ufrgs.br/bitstream/10183/217931/2/001121246.pdf.txt32b199e62643f63f27a0fa7689aaa2ddMD52ORIGINAL001121246.pdfTexto completo (inglês)application/pdf2173454http://www.lume.ufrgs.br/bitstream/10183/217931/1/001121246.pdff8b7a6592ce0ca997a91a07e5abccd73MD5110183/2179312021-03-09 04:29:26.277583oai:www.lume.ufrgs.br:10183/217931Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-03-09T07:29:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Shared genetic background between children and adults with attention deficit/hyperactivity disorder
title Shared genetic background between children and adults with attention deficit/hyperactivity disorder
spellingShingle Shared genetic background between children and adults with attention deficit/hyperactivity disorder
Rovira, Paula
Marcadores genéticos
Transtorno do déficit de atenção com hiperatividade
Criança
Adulto
Metanálise
Patrimônio genético
title_short Shared genetic background between children and adults with attention deficit/hyperactivity disorder
title_full Shared genetic background between children and adults with attention deficit/hyperactivity disorder
title_fullStr Shared genetic background between children and adults with attention deficit/hyperactivity disorder
title_full_unstemmed Shared genetic background between children and adults with attention deficit/hyperactivity disorder
title_sort Shared genetic background between children and adults with attention deficit/hyperactivity disorder
author Rovira, Paula
author_facet Rovira, Paula
Grevet, Eugenio Horácio
Hutz, Mara Helena
Rovaris, Diego Luiz
Oliveira, Angélica Salatino de
Silva, Bruna Santos da
Bau, Claiton Henrique Dotto
Rohde, Luis Augusto Paim
Ribasés, Marta
author_role author
author2 Grevet, Eugenio Horácio
Hutz, Mara Helena
Rovaris, Diego Luiz
Oliveira, Angélica Salatino de
Silva, Bruna Santos da
Bau, Claiton Henrique Dotto
Rohde, Luis Augusto Paim
Ribasés, Marta
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rovira, Paula
Grevet, Eugenio Horácio
Hutz, Mara Helena
Rovaris, Diego Luiz
Oliveira, Angélica Salatino de
Silva, Bruna Santos da
Bau, Claiton Henrique Dotto
Rohde, Luis Augusto Paim
Ribasés, Marta
dc.subject.por.fl_str_mv Marcadores genéticos
Transtorno do déficit de atenção com hiperatividade
Criança
Adulto
Metanálise
Patrimônio genético
topic Marcadores genéticos
Transtorno do déficit de atenção com hiperatividade
Criança
Adulto
Metanálise
Patrimônio genético
description Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. These findings confirm that persistent ADHD in adults is a neurodevelopmental disorder and extend the existing hypothesis of a shared genetic architecture underlying ADHD and different traits to a lifespan perspective
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-02-12T04:06:00Z
dc.type.driver.fl_str_mv Estrangeiro
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dc.identifier.issn.pt_BR.fl_str_mv 0893-133X
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identifier_str_mv 0893-133X
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. London. Vol. 45 (2020), p. 1617–1626
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eu_rights_str_mv openAccess
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institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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