Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/230473 |
Resumo: | Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories. |
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Diniz, Maria de Fátima Haueisen SanderBeleigoli, Alline Maria RezendeSchmidt, Maria InêsDuncan, Bruce BartholowRibeiro, Antônio Luiz PinhoVidigal, Pedro GuatimosimBenseñor, Isabela Judith MartinsLotufo, Paulo AndradeSantos, Itamar de SouzaGriep, Rosane HarterBarreto, Sandhi Maria2021-10-05T04:26:35Z20200102-311Xhttp://hdl.handle.net/10183/230473001131140Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories.application/pdfengCadernos de saúde pública = Reports in public health. Rio de Janeiro, RJ. Vol. 36, n. 8 (2020), e00072120, p. 1-7.Estudos de coortesSíndrome metabólicaResistência à insulinaMetabolic syndromeInsulin resistanceCohort studiesHomeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil studyModelo de avaliação da homeostase de resistência à insulina (HOMA-IR) e síndrome metabólica na linha de base de uma coorte brasileira multicêntrica : estudo ELSA-BrasilModelo homeostático para evaluar la resistencia a la insulina (HOMA-IR) y síndrome metabólico en la línea de base de una cohorte brasileña multicéntrica : estudio ELSA-Brasilinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001131140.pdf.txt001131140.pdf.txtExtracted Texttext/plain22244http://www.lume.ufrgs.br/bitstream/10183/230473/2/001131140.pdf.txta26354de9a602de31edcad7e08e20ce0MD52ORIGINAL001131140.pdfTexto completo (inglês)application/pdf181240http://www.lume.ufrgs.br/bitstream/10183/230473/1/001131140.pdf6670668d12b2417cbb605a3bd64e5e17MD5110183/2304732021-11-20 06:04:58.385354oai:www.lume.ufrgs.br:10183/230473Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T08:04:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
dc.title.alternative.pt.fl_str_mv |
Modelo de avaliação da homeostase de resistência à insulina (HOMA-IR) e síndrome metabólica na linha de base de uma coorte brasileira multicêntrica : estudo ELSA-Brasil |
dc.title.alternative.es.fl_str_mv |
Modelo homeostático para evaluar la resistencia a la insulina (HOMA-IR) y síndrome metabólico en la línea de base de una cohorte brasileña multicéntrica : estudio ELSA-Brasil |
title |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
spellingShingle |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study Diniz, Maria de Fátima Haueisen Sander Estudos de coortes Síndrome metabólica Resistência à insulina Metabolic syndrome Insulin resistance Cohort studies |
title_short |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
title_full |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
title_fullStr |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
title_full_unstemmed |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
title_sort |
Homeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil study |
author |
Diniz, Maria de Fátima Haueisen Sander |
author_facet |
Diniz, Maria de Fátima Haueisen Sander Beleigoli, Alline Maria Rezende Schmidt, Maria Inês Duncan, Bruce Bartholow Ribeiro, Antônio Luiz Pinho Vidigal, Pedro Guatimosim Benseñor, Isabela Judith Martins Lotufo, Paulo Andrade Santos, Itamar de Souza Griep, Rosane Harter Barreto, Sandhi Maria |
author_role |
author |
author2 |
Beleigoli, Alline Maria Rezende Schmidt, Maria Inês Duncan, Bruce Bartholow Ribeiro, Antônio Luiz Pinho Vidigal, Pedro Guatimosim Benseñor, Isabela Judith Martins Lotufo, Paulo Andrade Santos, Itamar de Souza Griep, Rosane Harter Barreto, Sandhi Maria |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Diniz, Maria de Fátima Haueisen Sander Beleigoli, Alline Maria Rezende Schmidt, Maria Inês Duncan, Bruce Bartholow Ribeiro, Antônio Luiz Pinho Vidigal, Pedro Guatimosim Benseñor, Isabela Judith Martins Lotufo, Paulo Andrade Santos, Itamar de Souza Griep, Rosane Harter Barreto, Sandhi Maria |
dc.subject.por.fl_str_mv |
Estudos de coortes Síndrome metabólica Resistência à insulina |
topic |
Estudos de coortes Síndrome metabólica Resistência à insulina Metabolic syndrome Insulin resistance Cohort studies |
dc.subject.eng.fl_str_mv |
Metabolic syndrome Insulin resistance Cohort studies |
description |
Homeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-10-05T04:26:35Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/230473 |
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0102-311X |
dc.identifier.nrb.pt_BR.fl_str_mv |
001131140 |
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url |
http://hdl.handle.net/10183/230473 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Cadernos de saúde pública = Reports in public health. Rio de Janeiro, RJ. Vol. 36, n. 8 (2020), e00072120, p. 1-7. |
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openAccess |
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